Effects of some rhinencephalic lesions on retention of conditioned avoidance behavior in cats.

Ry, Moore

doi:10.1037/h0042989

Cited by 55 publications

(24 citation statements)

References 20 publications

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“…Lastly, recent neurological evidence suggests that a system more complex than the "Papezcircuit" functions in raising the probabilities of re-40 sponses needed for task solution. Moore (1964) reports that septal and hippocampal lesions produce deficiencies on active avoidance retention, while Kimble (1964) reports no effect of a hippocampal lesion on a passive avoidance task similar to that used in this paper. Teitelbaum & Milner (1963), however, have demonstrated that hippocampal lesioned Ss are deficient on this type of avoidance task.…”

Section: Resultsmentioning

confidence: 89%

The effects of anteromedial and dorsomedial thalamic lesions on passive avoidance and activity

Gerbrandt

1965

Psychon Sci

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Animals were tested for anteromedial and dorsomedial thalamic nucleus lesion effects on three activity tests and on a passive avoidance task. Insignificant effects were obtained on the activity tests and there was no correlation between activity scores and passive avoidance performance. The anteromedial thalamic lesioned group were retarded on passive avoidance performance while surgical controls and the dorsomedial thalamic nucleus lesioned group rapidly learned the avoidance response. ProblemIn a recent review of much of the neurological literature (Gerbrandt, 1964) it was concluded that the passive and active avoidance tasks represented fundamentally different problem solving situations in which the operation of distinct brain systems is critical. On the one hand, the passive avoidance task was used as a prototype for situations where the correct task solution was of a low probability of elicitation and in competition with a standing response of a higher probability of elicitation. The active avoidance task, however, was used as a prototype for situations necessitating the immediate elicitation of a high probability response where lower probability mediating responses might interfere. Lesions within a circuit similar to that suggested by Papez (1937) seemed to interfere with r a is e pro b a b i Ii t Y functions, while lesions within much of the medial and nonspecific thalamic nuclei and their projection fields seemed to interfere with h i g h pro b a b iIi t y functions.This investigation is intended to fill in two of the gaps which were left in the research relevant to the anatomical generalizations previously made. First, although it is well known that the anteromedial thalamic nucleus is an important link in the Papez circuit, this nucleus has not been specifically lesioned and the animal tested for functioning on a passive avoidance task. Second, the dorsomedial thalamic nucleus has been implicated as functioning on active avoidance tasks (Thompson, 1963) but these lesioned Ss were not tested for passive avoidance performance. In the present study Ss are lesioned in the dorsomedial and anteromedial thalamic nuclei and tested for passive avoidance performance. MethodA total of 30 male hooded rats at 120 days of age were divided into groups of 10 each for surgical treatments. All Ss were anesthetized with Nembutal, stereotaxically mounted, and were surgically prepared for electrode trephining. The surgical control (SC) Ss were sutured PI)'Chon. Sci., 1965, VoL 2.

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Section: Resultsmentioning

confidence: 89%

The effects of anteromedial and dorsomedial thalamic lesions on passive avoidance and activity

Gerbrandt

1965

Psychon Sci

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“…Reports on the effects of lesions in this region range from complete loss of memory to slight or no impairment at all. Deficits in memory have been demonstrated on tasks that require active avoidance from shock (McCleary et aI, 1965;Moore, 1964;Rich & Thompson, 1965), on a complex maze (Carey, 1968), by means of an extinction test (Carey, 1967), and to a lesser extent on a brightness discrimination task (Schwartzbaum et aI, 1964). A number of other studies have reported that septal lesions disrupt preoperatively conditioned behavior (e.g., Burkett & Bunnell, 1966; Schwartzbaum et aI, 1964).…”

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Retention of a geotaxic discrimination task following septal lesions in rats

Holdstock

Edelson

1969

Psychon Sci

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Septal lesions did not impair retention of a simple discrimination task that was based on geotaxic cues, but it did disturb the ability of the animals to make fine discriminations and prolonged extinction when the animals were not preloaded with water.Several recent studies have investigated the importance of the septal area in retention. Reports on the effects of lesions in this region range from complete loss of memory to slight or no impairment at all. Deficits in memory have been demonstrated on tasks that require active avoidance from shock (McCleary et aI, 1965;Moore, 1964;Rich & Thompson, 1965), on a complex maze (Carey, 1968), by means of an extinction test (Carey, 1967), and to a lesser extent on a brightness discrimination task (Schwartzbaum et aI, 1964). A number of other studies have reported that septal lesions disrupt preoperatively conditioned behavior (e.g., Burkett & Bunnell, 1966; Schwartzbaum et aI, 1964). However, it is uncertain whether these effects represent a retention loss or are only secondary to some motivational and motor disinhibitory effects of septal damage. Septal lesions failed to impair retention of a thirst habit in a shuttle-box situation (Breen & Thompson, 1966), and of a black-white discrimination that was based on shock (Kleiner et aI, 1967; Meyer et aI, 1968). Rats were even found to improve their performance in a linear runway after destruction of the septal area (Raphelson et aI, 1966).The present experiment extends the inquiry to the effects of septal lesions on the retention of a discrimination based on geotaxic cues. An added incentive for using this task was that it presented a novel experimental procedure for tests of discrimination. METHOD Preoperative Tests Twelve male Sprague-Dawley rats (250-300 g) were taught to discriminate between geotaxic cues on the basis of water reinforcement. The data of two animals had to be discarded due to illness and death during the experiment. Following 23-h water deprivation, each animal was initially trained to press a lever for 0.1 ml of water while the test chamber was in a level position. Discrimination training usually Psychon. Sci., 1969, Vol. 15 (3) started on the third session and introduced tilting the cage 20 deg. The apparatus was adapted in such a way that the side of the cage housing the lever was free to move through various degrees of tilt, while the opposite side was fixed to a hinge. Each daily session during discrimination consisted of 18 trials, 60 sec in duration. On nine trials the cage was level and all responses were reinforced (S+). On the other nine trials the cage was tilted 20 deg and responses were never reinforced (S-). The session always started with a reinforced trial. The remaining S+ trials were distributed randomly among the S-trials, with the restriction of no more than three consecutive trials with either condition. Between trials the cage was raised and lowered a few times so as not to condition the animals to the direction of movement. Training on the discrimination continued for each S unti...

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“…The species generality of this reaction appears to be limited. For example, changes in emotionality after septal lesions are seen only occasionally in cats [Moore, 1964] and not at all in monkeys [Buddington et al, 1967], In addition, much attention has been directed toward the hypothesis …”

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Hyperemotionality and Enhanced Tonic Immobility after Septal Lesions in the Rabbit

Woodruff

Lippincott

1976

Brain Behav Evol

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Large lesions of the septal region in the rabbit increased tonic immobility as measured by the number of successful inductions and by duration of immobility. Open field activity was also increased. Septally lesioned rabbits also exhibited increased emotionality, although the topography of the ''septal syndrome'' in these rabbits was different from that described for rats. The septally lesioned rabbits exhibited increases in fear reactions such as thumping, escape responses and vocalization when caught, rather than increased aggressiveness. The results are discussed in terms of loss of inhibition of species-typical responses after septal damage.

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Effects of some rhinencephalic lesions on retention of conditioned avoidance behavior in cats.

Cited by 55 publications

References 20 publications

The effects of anteromedial and dorsomedial thalamic lesions on passive avoidance and activity

The effects of anteromedial and dorsomedial thalamic lesions on passive avoidance and activity

Retention of a geotaxic discrimination task following septal lesions in rats

Hyperemotionality and Enhanced Tonic Immobility after Septal Lesions in the Rabbit

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