Effects of some sulfur-containing antioxidants on lead-exposed lenses

Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver

“…Decreased activity of GST observed in the present study might be due to inhibition of protein structure by lead and due to want of substrate. Evidence for the inhibition of GST, GR by lead along with a fall in GSH comes from the report made by Neal et al [70]. Table 3 Effect of lipoic acid, meso 2,3-dimercaptosuccinic acid and lead on glutathione and glutathione metabolizing enzymes in rat liver Previous report from our laboratory has shown the beneficial effects of the combined administration of LA and DMSA in reversing the oxidative damage to the kidney of lead poisoned rats [24].…”

Involvement of some low-molecular thiols in the peroxidative mechanisms of lead and ethanol action on rat liver and kidney

“…Binding of Pb into SH groups of GSH results in a decrease in the GSH oxidative potential. Like EtOH, Pb can decrease the concentration of GSH as a result of inhibiting the activities of enzymes involved in GSH metabolism, such as GR, G6PD and glutathione S-transferase (GST), via blocking their SH groups (Lachant et al, 1984;Jindal and Gill, 1999;Neal et al, 1999;Sivaprasad et al, 2004). Pb might induce lipid peroxidation not only via a decrease in GSH and NPSH concentrations, but also via an indirect induction of free radicals.…”

On-Set of Cataract and Accumulation of Copper, Lead and Cadmium in Smokers of Karachi, Pakistan

“…As metals have a long halflife deposition in tissues occur [61] the radicals produced can cause peroxidation of Lipids, biomolecules degradation and breakup of DNA strand [81]. Cumulative damage to mitochondria can occur due to oxidative damage which is important for providing energy and cell survival [82], these metals can directly bind to antioxidant enzymes like Glutathione & increases their inactivated form to get deposited in lens [83]. Metals combine with protein and enzymes having thiol group impairing their function directly and also indirectly as antioxidant enzymes such as reduced Glutathione, which keeps thiol groups in reduced form responsible for transparency of lens [84].…”