Effects of Some Xenobiotics on Ascorbic Acid Metabolism in Rats

Horio, Fumihiko; Yoshida, A.

doi:10.1093/jn/112.3.416

Cited by 60 publications

(14 citation statements)

References 29 publications

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“…1A). It is known that the ascorbic acid formation increases when the rats are exposed to xenobiotics to metabolize and excrete into urine (36). A large amount of PaA administration to the rats did not induce the formation of ascorbic acid (Fig.…”

Section: Discussionmentioning

confidence: 92%

Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats

Shibata

Takahashi

Fukuwatari

et al. 2005

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryTo acquire the data concerning the tolerable upper intake level which prevents health problems from an excessive intake of pantothenic acid, an animal experiment was done. Rats of the Wistar strain (male, 3wk old) were fed on a diet which contains 0%, 0.0016% (control group), 1%, or 3% calcium pantothenate for 29d. The amount of weight increase, the food intake, and the organ weights were measured, as well as the pantothenic acid contents in urine, the liver and blood. Moreover, to learn the influence of excessive pan tothenic acid on other water-soluble vitamin metabolism, thiamin, riboflavin, a vitamin B6 catabolite, the niacin catabolites, and ascorbic acid in urine were measured. As for the 3% addition group, enlargement of the testis, diarrhea, and hair damage were observed, and the amount of weight increase and the food intake were less than those of the control group. However, abnormality was not seen in the 1% addition group. The amount of pantothenic acid in urine, the liver, and blood showed a high correlation with intake level of pantothenic acid. It was only for 4-pyridoxic acid, a vitamin B6 catabolite, in urine that a remarkable dif ference was observed against the control group. Moreover, the (2-Py+4-Py)/MNA excretion ratio for these metabolites of the nicotinamide also indicated a low value in the 3% pan tothenic acid group. As for the calcium pantothenate, it was found that the 3% level in the diet was the lowest-observed-adverse-effect-level (LOAEL) and the 1% level was the no observed-adverse-effect-level (NOAEL).

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Section: Discussionmentioning

confidence: 92%

Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats

Shibata

Takahashi

Fukuwatari

et al. 2005

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Administration of these xenobiotics increases liver ascorbic acid concentration and its urinary excretion in rats. The formation of D-glucuronate from UDP-glucose is rate-limiting in ascorbic acid synthesis because the activities of UDP-glucose dehydrogenase, which cata- lyzes UDP-glucuronate formation from UDP-glucose, and UGT but not L-gulono-␥-lactone oxidase, are elevated by some xenobiotics such as PCB and DDT in rats (34,35). Because ␤-glucuronidase activity is elevated by PCB, DDT, chloretone or aminopyrine (34), some xenobiotics may stimulate ascorbic acid synthesis by the induction of a UGT/␤-glucuronidase-mediated pathway.…”

Section: Discussionmentioning

confidence: 99%

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Ikeda

Abe

Uchida

et al. 2007

J Nutr Sci Vitaminol

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SummaryWe previously showed that the intake of sesamin, a major lignan in sesame seed, decreased lipid peroxidation and elevated tocopherol concentration in rat tissues. In this study, we examined the effect of dietary sesame seed and sesamin on the ascorbic acid concentration in rat tissues. Rats (4-wk-old) were fed either a vitamin E-free diet, or a diet containing 50 mg ␥ -tocopherol/kg, one containing 2 g sesamin/kg, one containing 50 mg ␥ -tocopherol/kg and 2 g sesamin/kg, or one containing 200 g sesame seed/kg for 28 d. The dietary sesamin and sesame seed elevated ascorbic acid concentrations in the liver and kidney, and increased urinary excretion in those Wistar rats. The dietary sesamin also elevated the hepatic mRNA levels of cytochrome P450 (CYP) 2B, and UDP-glucuronosyltransferase (UGT) 1A and 2B. In contrast, neither the sesamin nor the sesame seed affected the liver concentration of ascorbic acid in ODS rats with a hereditary defect in ascorbic acid synthesis, though the dietary sesame seed elevated the UGT1A and 2B mRNA levels in the liver. In addition, the sesame seed elevated the ␥ -tocopherol concentration in the various ODS rat tissues and the ascorbic acid concentrations in the kidney, heart and lung, while reducing the thiobarbituric acid reactive substance concentration in the heart and kidney. These results suggest that dietary sesame seed and its lignan stimulate ascorbic acid synthesis as a result of the induction of UGT1A and the 2B-mediated metabolism of sesame lignan in rats. The data of ODS rat studies also suggest that dietary sesame seed enhances antioxidative activity in the tissues by elevating the levels of two antioxidative vitamins, vitamin C and E. Key Words ascorbic acid, sesamin, sesame seed, UDP-glucuronosyltransferase, vitamin C Dietary sesame seed or its lignan, such as sesamin and sesaminol, elevates tocopherol concentration in the serum and tissues of rats fed tocopherol ( 1 -5 ). Dietary sesame lignan elevates the tocopherol concentration in tissues by inhibiting tocopherol metabolism to its metabolite because the dietary sesamin or sesaminol markedly decreases the urinary excretion of 2,7,8-trimethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␥ -CEHC), a major metabolite of ␥ -tocopherol, in rats fed a diet containing ␥ -tocopherol ( 4 ). We also showed that the concentration of thiobarbituric acid reactive substance (TBARS) in the tissues and plasma (or serum) was decreased by dietary sesame seed or its lignan ( 1 , 2 , 4 , 5 ). It was recently reported that dietary sesame seed or sesame oil consumption reduced the urinary excretion of ␥ -CEHC ( 6 ), elevated the plasma (or serum) ␥ -tocopherol concentration ( 7-9 ), and decreased serum TBARS concentration ( 9 ) in humans. These data suggest that dietary sesame lignan elevates tocopherol concentration in the serum and tissues by inhibiting its metabolism, and decreases lipid peroxidation by inducing a high tocopherol concentration in humans and rats.

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“…Horio et al have reported that the induction of uridine 5′‐diphospho‐glucuronosyltransferase (UGT) in rats treated with phenobarbital and 3‐MC caused an increase in AsA levels in the liver, and AsA excretion in the urine was higher 6. It has also been reported that supplementation with several xenobiotics stimulates the activities of DME and AsA biosynthesis in rats 5,10,11. However, the mechanisms whereby AsA is involved with xenobiotic‐metabolizing enzymes are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Dose of 3‐methylcholanthrene enhances vitamin C accumulation and mRNA expression of its transporter in the liver of ODS rats and in HepG2 cells

Sone

Ueta

Sannomaru

et al. 2011

J Biochem & Molecular Tox

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Polycyclic aromatic hydrocarbon (PAH) compounds including 3-methylcholanthrene induce harmful reactive intermediates and reactive oxygen species. This study reports the effect of 3-methylcholanthrene on the accumulation of vitamin C and the expression of vitamin C transporters. ODS rats were given l-ascorbic acid daily and intraperitoneal injections of 10 mg 3-methylcholanthrene in total. On day 10, vitamin C concentrations and the expression of vitamin C transporter in the tissues were measured. As a result, the levels of sodium-dependent vitamin C transporter (SVCTs) 1 and the l-ascorbic acid concentration in 3-methylcholanthrene-treated livers and hepatocytes have increased significantly. However, the content of vitamin C in the urine and TBARS in the liver have not changed. These results suggest that the administration of 3-methylcholanthrene elevates the requirement for vitamin C via (SVCTs) 1 due to xenobitics-metabolizing, such as the induction of cytochrome P450 family.

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Effects of Some Xenobiotics on Ascorbic Acid Metabolism in Rats

Cited by 60 publications

References 29 publications

Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats

Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Dose of 3‐methylcholanthrene enhances vitamin C accumulation and mRNA expression of its transporter in the liver of ODS rats and in HepG2 cells

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