Effects of soy isoflavones on serum systemic and vascular inflammation markers and oxidative stress in peritoneal dialysis patients: A randomized controlled trial

Abstract

Cardiovascular disease (CVD) is common in peritoneal dialysis (PD) patients. This study was designed to investigate the effects of isoflavones on systemic and vascular inflammation markers and oxidative stress in PD patients. In this randomized clinical trial, 40 PD patients were randomly assigned to either the isoflavone or the placebo group. The isoflavone group received 100 mg soy isoflavones daily for 8 weeks, whereas the placebo group received corresponding placebos. At baseline and the end of eighth week, serum high sensitive C-reactive protein (hs-CRP), intercellular adhesion molecule type 1 (ICAM-1), vascular cell adhesion molecule type 1 (VCAM-1), E-selectin, and malondialdehyde were measured. Serum VCAM-1 decreased significantly in the isoflavone group at the end of Week 8 compared to baseline (p = .01), whereas no significant change was observed in the placebo group. Serum ICAM-1 decreased significantly in the isoflavone (p = .01) and placebo (p = .01) group compared to baseline. However, the reduction of ICAM-1 was significantly higher in the isoflavone group than in the placebo group (p = .02). There were no significant differences between the two groups in mean changes of serum E-selectin, malondialdehyde, and hs-CRP. This study indicates that isoflavones reduce serum VCAM-1 and ICAM-1, which are two CVD risk factors, in PD patients.

Fermentation of soymilk by Lactobacillus acidipiscis isolated from Chinese stinky tofu capable of efficiently biotransforming isoflavone glucosides to dihydrodaidzein and dihydrogenistein

“…Soymilk fermented with lactic acid bacteria has increased contents of amino acids, antioxidant peptides and antihypertensive peptides, 4 as well as decreased antinutritional factor content and immunogenicity 33 . In addition, fermented soymilk is rich in soy isoflavones, which have human health benefits to bones, blood, skin, sleep, immunity and other aspects 34,35 . Soy isoflavones undergo metabolism by the intestinal microflora, prior to absorption into the circulation, and the metabolites are generally more biologically active than their precursors 8 .…”

Emerging Roles of Sodium Glucose Cotransporter 2 (SGLT-2) Inhibitors in Diabetic Cardiovascular Diseases: Focusing on Immunity, Inflammation and Metabolism

“…There is much evidence showing that the major inflammatory cytokines during this process are the IL-1 family ( Carty et al, 2009 ; Herder et al, 2017 ; Pfeiler et al, 2019 ), IL-6 ( Carty et al, 2009 ; Prochnau et al, 2012 ; Morieri et al, 2017 ), IL-17 ( Madsen et al, 2016 ), IL-18 ( Buraczynska et al, 2016 ; Lee et al, 2019 ), IL-32 ( Damen et al, 2017 ), TNF-α ( Singh et al, 2005 ; Shen et al, 2016 ), C-reactive protein (CRP) ( Chiang et al, 2019 ; Martin-Nunez et al, 2020 ). Adhesion Molecules are also very important, such as vascular cell adhesion molecule-1 (VCAM-1) ( Denys et al, 2016 ; Kunutsor et al, 2017 ; Cao et al, 2020 ; Yari et al, 2020 ), intercellular adhesion molecule-1 (ICAM-1) ( Cao et al, 2020 ; Yari et al, 2020 ), and platelet endothelial cell adhesion molecule-1 (PECAM-1) ( Stevens et al, 2008 ). SGLT-2 inhibitors are recognized as effective agents for decreasing these inflammatory factors.…”

Biomarkers and Mechanisms of Oxidative Stress—Last 20 Years of Research with an Emphasis on Kidney Damage and Renal Transplantation

“…Oxidative stress is recognized as a risk factor for various adverse events, including atherosclerosis and mortality in chronic kidney disease (CKD) patients. From the early stages of the disease, oxidative stress accompanies the deterioration of renal function, which is further aggravated by hemodialysis [ 14 , 15 , 16 ]. Data suggest that cardiovascular complications in patients undergoing hemodialysis are aggravated by oxidative imbalance, which may be a potential target for therapy [ 17 ].…”