Effects of soy isoflavones on 17β-estradiol-induced proliferation of MCF-7 breast cancer cells

Imhof, Marianne; Molzer, Sylvia; Imhof, Martin

doi:10.1016/j.tiv.2008.04.018

Cited by 26 publications

(22 citation statements)

References 30 publications

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“…In agreement, a more physiological mouse model with postmenopausal estrogen levels demonstrated an additional proliferative effect of genistein [58]. However, the addition of 17β-estradiol in only low postmenopausal levels of 20 pmol/l induced antiproliferative effects on MCF-7 cells by isoflavonoids [59]. Furthermore, the injection of murine or human ER-negative breast carcinoma cells into soy-fed BALB/c mice resulted in reduced metastasis and tumor growth [60,61].…”

Section: Isoflavones and Risk Of Breast Cancer Recurrencementioning

confidence: 77%

Isoflavones – Mechanism of Action and Impact on Breast Cancer Risk

Stubert¹,

Gerber²

2009

Breast Care

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Isoflavones are plant-derived substances with weak estrogenic effects. Asian populations are high consumers of soy products which are rich in isoflavones. The lower breast cancer incidence in Asian women compared with Western women has been associated with the possibility of a preventive isoflavone effect on cancer risk. The aim of this review is to give an overview of current research data on the influence of isoflavones on the risk of primary breast cancer development as well as the risk of recurrence in breast cancer patients. Despite inconsistencies in the available data, an inverse correlation between isoflavone intake and risk of breast cancer is likely. However, a negative impact on breast cancer disease, especially on hormone receptor-positive tumors, cannot be excluded at present.

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Section: Isoflavones and Risk Of Breast Cancer Recurrencementioning

confidence: 77%

Isoflavones – Mechanism of Action and Impact on Breast Cancer Risk

Stubert¹,

Gerber²

2009

Breast Care

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“…In our study, a significant association was found only among postmenopausal women. Some studies have suggested possible antiestrogenic effects (Duncan et al, 1999;Xu et al, 2000) and antiproliferative effects (Imhof and Molzer, 2008) of soy in postmenopausal women. In addition, the reported modified effects of hormone receptor status (Suzuki et al, 2008), body mass index (Wu et al, 2008a) and equol status (Fuhrman et al, 2008) on soy-breast cancer associations in postmenopausal women also explain the inconsistent findings of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status

et al. 2010

Eur J Clin Nutr

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Background: Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent. Objective: We investigated the effects of soy intake on breast cancer risk among Korean women according to their menopausal and hormone receptor status. Methods: We conducted a case-control study with 358 incident breast cancer patients and 360 age-matched controls with no history of malignant neoplasm. Dietary consumption of soy products was examined using a 103-item food frequency questionnaire. Results: The estimated mean intakes of total soy and isoflavones from this study population were 76.5 g per day and 15.0 mg per day, respectively. Using a multivariate logistic regression model, we found a significant inverse association between soy intake and breast cancer risk, with a dose-response relationship (odds ratios (OR) (95% confidence interval (CI)) for the highest vs the lowest intake quartile: 0.36 (0.20-0.64)). When the data were stratified by menopausal status, the protective effect was observed only among postmenopausal women (OR (95% CI) for the highest vs the lowest intake quartile: 0.08 (0.03-0.22)). The association between soy and breast cancer risk did not differ according to estrogen receptor (ER)/progesterone receptor (PR) status, but the estimated intake of soy isoflavones showed an inverse association only among postmenopausal women with ER þ /PR þ tumors. Conclusions: Our findings suggest that high consumption of soy might be related to lower risk of breast cancer and that the effect of soy intake could vary depending on several factors.

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“…They also found that diet is not as effective as hormone replacement therapy (Chiechi et al, 2002a). Imhof et al (2008) findings showed safety improvement of the conventional hormonal replacement therapy by boosting the clinical combination of estrogens and soy isoflavones, especially regarding the risk of breast cancer (Imhof et al, 2008). Wood et al (2007) reported that diet containing isoflavones lead to reduction of catabolism of estradiol by 21-26%, since the estrogens circulate predominately as inactive sulfate which are deconjugated within peripheral tissues, selectively catabolized and excreted.…”

Section: Discussionmentioning

confidence: 99%

Can Soy Change Serum Estradiol Concentration in Neonate Ovariectomized Rat?

N.¹

2012

American Medical Journal

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Problem statement: Phytoestrogens are plant derived compound found in a wide variety of foods, most notably soy. The purpose of this study was to assess the effect of soy isoflavones on circulating 17-β estradiol in neonate ovariectomized rat. Approach: Thirty, one day olds rats were used. Blood sample were collected after two months. 17-β estradiol was assayed by radioimmuno assay method. Data were analyzed by one way ANOVA and Duncan as post-hoc test. The level of significance was considered p<0.05. Results: Our data showed that ovariectomy significantly (p<0.05) reduced serum 17-β estradiol. Application of soy in doses 0.75 and 1.5 mL kg −1 day −1 following ovariectomy had not significant effect relative to ovariectomy without application of soy, but application of soy in dose 3 mL kg −1 day −1 significantly (p<0.05) increased 17-β estradiol relative to ovariectomy without application of soy. There was no significant difference between dose 3 mL kgday −1 and control and sham group. Conclusion/Recommendation: Our results indicated that soy milk isoflavone can compensate the 17-β estradiol decrease in ovariectomized rat.

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Effects of soy isoflavones on 17β-estradiol-induced proliferation of MCF-7 breast cancer cells

Cited by 26 publications

References 30 publications

Isoflavones – Mechanism of Action and Impact on Breast Cancer Risk

Isoflavones – Mechanism of Action and Impact on Breast Cancer Risk

Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status

Can Soy Change Serum Estradiol Concentration in Neonate Ovariectomized Rat?

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