Effects of Soy on Health Outcomes: Evidence Report/Technology Assessment, Number 126

Supplementation of Soy Isoflavones Improved Sex Hormones, Blood Pressure, and Postmenopausal Symptoms

“…Further, the effect of soy supplementation on each symptom on the Kuppermann's index was assessed. Similar findings have been reported by Balk et al [10] and Lethaby et al [29].…”

“…Results from a number of clinical and crossover trials have suggested that soy supplementation in different forms is beneficial for improving some menopausal symptoms but not others [9][10][11][12][13][14][15][16]. A study by Albertazzi showed that soy protein was significantly superior to other proteins and reduced the number of hot flashes [17].…”

Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials

“…Although the Jadad et al [10]'s scale has often been used to assess the quality of RCTs in meta-analyses, we used the three-category grading system (A, B, and C) used in the Agency for Healthcare Research and Quality [9] report on soy to denote the methodological quality of each study. Category A studies have the least bias and results are considered valid; category B studies are susceptible to some bias, but not sufficient to invalidate the results; and category C studies have significant bias that may invalidate the results (e.g., dropout rate >20%, missing baseline data, or irreconcilable apparent differences between data in figures, tables, and text).…”

“…For the PubMed search, free keywords for soy isoflavones were mapped to appropriate indices terms. Reference lists of included RCTs and relevant systematic reviews and meta-analyses [7,9] were manually searched. We also contacted some authors to ask about additional studies.…”

Chemoprevention of prostate cancer: What can be recommended to patients?

“…A more recent population-based prospective study in 43,509 Japanese men found that high intakes of isofl avones were associated with lower levels of localized prostate cancer but higher levels of advanced prostate cancer [45]. Also, the Agency for Healthcare Research and Quality issued a report examining 178 prospective studies of soy foods, concluding that the evidence supporting a protective benefi t against cancer was limited [46].…”