Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes

Liu, Zhaomin; Chen, Yuming; Ho, Suzanne C.; Ho, Yee-Ping; Woo, Jean

doi:10.3945/ajcn.2009.28813

Cited by 74 publications

(54 citation statements)

References 30 publications

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“…Recently, Liu et al reported that SP with or without isoflavone did not have favorable effects on glycemic control and insulin sensitivity, even though BW was not changed at 6 months among Chinese women in a randomized, placebo-controlled trial. 22 These data indicate that formula food containing MP is superior to the same food containing SP for reducing visceral fat.…”

Section: Formula Food With Soy Protein Vs Milk Proteinmentioning

confidence: 69%

Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity - FLAVO Study -

Takahira

Noda

Fukushima

et al. 2011

Circ J

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Section: Formula Food With Soy Protein Vs Milk Proteinmentioning

confidence: 69%

Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity - FLAVO Study -

Takahira

Noda

Fukushima

et al. 2011

Circ J

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“…An RCT conducted on 180 postmenopausal women with prediabetes or early untreated diabetes, treated with soy protein with or without isoflavone supplementation for 6 months, did not find any evidence of favorable effects on glycemic control and insulin sensitivity [142].…”

Section: Soy Isoflavonesmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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“…However, others showed no significant effect of soya protein (27)(28)(29) and soya isoflavone (27,30,31) . The results of an experimental study suggested that soyabean protein has the potential to improve insulin resistance or ameliorate obesity by inhibiting lipogenesis and promoting lipolysis in the liver and adipose cells (32) .…”

Section: Discussionmentioning

confidence: 99%

Inverse association between soya food consumption and insulin resistance in Japanese adults

Nakamoto

Uemura²,

Sakai³

et al. 2014

Public Health Nutr.

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Objective: The purpose of the present study was to examine the association between soya food consumption and insulin resistance using baseline data of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. Design: This cross-sectional study included 1274 subjects, aged 34-70 years at baseline, living in Tokushima Prefecture between 2008 and 2013. Fasting blood samples were collected and information on lifestyle characteristics including soya food intake and medical history were obtained using a structured selfadministered questionnaire. The homeostasis model assessment of insulin resistance (HOMA-IR) was measured and those with HOMA-IR ≥ 2·5 were defined as having insulin resistance. Multiple logistic regression models were used to analyse the association between soya product intake and the prevalence of insulin resistance. Setting: Rural communities located in Tokushima Prefecture, Japan, between 2008 and 2013. Subjects: A total of 1148 adults (565 men and 583 women), aged 34-70 years. Results: The frequency of intake of miso soup, total non-fried soya products and total soya products showed significant inverse dose-response relationships with insulin resistance, after adjustments for potential confounders. When soya product intake was calculated as soya protein and isoflavone, the odds ratios of insulin resistance decreased significantly as the estimated intake of soya protein increased. Furthermore, significant inverse dose-response relationships were observed for total non-fried soya products and total soya products, after adjustment for total vegetable or total fibre consumption. Conclusions: The present results indicate that the intake of soya products and nonfried soya products is associated with reduced insulin resistance in the Japanese population.

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Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes

Cited by 74 publications

References 30 publications

Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity - FLAVO Study -

Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity - FLAVO Study -

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Inverse association between soya food consumption and insulin resistance in Japanese adults

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