Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats

Xie, Shouqi; Zhu, Jingjing; Zhang, Yanqi; Shi, Kai; Shi, Yanbin; Ma, Xiao

doi:10.1017/s0007114511006015

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…Cardiovascular disease (CVD) is the leading cause of mortality in the world and hypercholesterolemia is recognized as a major independent risk factor in CVD (1). Maintaining cholesterol levels in the normal range can help prevent the initiation and progression of CVD.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Um¹,

Ahn²,

Jung³

et al. 2013

JFN

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The aim of this study was to investigate the effects of isolated protein from white rice on lipid metabolism in a hypercholesterolemic animal model. Male Sprague-Dawley rats were divided into three groups and fed either a normal diet or a high-cholesterol diet (HCD) containing either casein or isolated rice protein for 4 weeks. Compared with rats fed a HCD with casein, the total cholesterol (TC) level in the plasma was significantly reduced in the rats fed rice protein. However, no significant differences were observed in the triglycerides, high-density lipoprotein (HDL), and glucose levels among the experimental groups. Hepatic total lipids and TC levels were significantly decreased by supplementation with rice protein. In addition, rice protein significantly increased the levels of TC and bile acids in the feces. These results suggest that rice protein may improve HCD-induced hypercholesterolemia by enhancing fecal excretion of cholesterol.

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Section: Introductionmentioning

confidence: 99%

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Um¹,

Ahn²,

Jung³

et al. 2013

JFN

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“…Although a previous study demonstrated that supplemental feeding with epilactose did not have an impact on the plasma lipid concentration in rats fed high-sucrose diets ( 20 ) , some prebiotic oligosaccharides reportedly exhibit an ameliorative effect on diet-induced obesity and metabolic dysregulation ( 9 , 21 , 22 ) . The present study showed that epilactose effectively prevents metabolic disorders probably through the up-regulation of UCP-1 expression in skeletal muscles and brown adipose tissue in mice fed HF diets.…”

Section: Discussionmentioning

confidence: 98%

Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets

et al. 2015

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Obesity is one of the major health problems throughout the world. The present study investigated the preventive effect of epilactose -a rare non-digestible disaccharide -on obesity and metabolic disorders in mice fed high-fat (HF) diets. Feeding with HF diets increased body weight gain, fat pad weight and adipocyte size in mice (P < 0·01), and these increases were effectively prevented by the use of supplemental epilactose without influencing food intake (P < 0·01). Caecal pools of SCFA such as acetic and propionic acids in mice fed epilactose were higher compared with mice not receiving epilactose. Supplemental epilactose increased the expression of uncoupling protein (UCP)-1, which enhances energy expenditure, to 2-fold in the gastrocnemius muscle (P = 0·04) and to 1·3-fold in the brown adipose tissue (P = 0·02) in mice fed HF diets. Feeding HF diets induced pro-inflammatory macrophage infiltration into white adipose tissue, as indicated by the increased expression of monocyte chemotactic protein-1, TNF-α and F4/80, and these increases were attenuated by supplemental epilactose. In differentiated myogenic-like C2C12 cells, propionic acid, but not acetic or n-butyric acids, directly enhanced UCP-1 expression by approximately 2-fold (P < 0·01). Taken together, these findings indicate that the epilactose-mediated increase in UCP-1 in the skeletal muscle and brown adipose tissue can enhance whole-body energy expenditure, leading to effective prevention of obesity and metabolic disorders in mice fed HF diets. It is suggested that propionic acid -a bacterial metabolite -acts as a mediator to induce UCP-1 expression in skeletal muscles.Key words: Epilactose: Propionic acid: Obesity: Uncoupling protein: Skeletal muscle Non-digestible carbohydrates such as dietary fibres and oligosaccharides have a variety of beneficial effects on our health. Epilactose (4-O-β-galactopyranosyl-D-mannose) is a rare nondigestible disaccharide, which can be produced in considerable amounts by heating and alkali treatment of cows' milk (1) . Recently, we have developed a method for the mass-production of epilactose using cellobiose 2-epimerase (EC 5.1.3.11) from the ruminal strain Ruminococcus albus NE1 (2) . Although our previous studies have found that epilactose enhances the absorption of intestinal Ca and Fe in rodents (3) , information on its biological functions remains quite limited. As previous studies have demonstrated that some non-digestible carbohydrates ameliorate metabolic disorders such as obesity, epilactose also may have a potential to prevent these disorders.Obesity and related diseases, such as diabetes and CVD, have emerged as major health problems in many countries, particularly in the West (4) . It is known that obesity and diabetes are the results of a complex interaction between genetic and environmental factors. In particular, the intake of a fat-enriched diet and intake of excessive calories are primary factors associated with the increased occurrence and further progression of metabolic disorders. At the ...

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“…singuonensis . The cholesterol‐lowering action of phytic acid (Jariwalla, 1999; Lee et al , 2005 b ), stachyose (Xie & Shi, 2006; Lan et al , 2007) and soy isoflavones (Kawakami et al , 2005; Mezei et al , 2006), however, has been well documented in terrestrial animals. These results appear to indicate either that cholesterol metabolism in fishes is different from that of terrestrial animals or that there is a multiplicity of mechanism involved in the control of cholesterolaemia in fishes (Kaushik et al , 1995; Dias et al , 2005), which needs further study.…”

Section: Discussionmentioning

confidence: 99%

Effects of antinutritional factors on plasma lipoprotein levels in Japanese flounder Paralichthys olivaceus

Deng

et al. 2011

Journal of Fish Biology

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This study examined the effects of four types of antinutritional factor (phytic acid, stachyose, soy saponins and soy isoflavones) on lipoprotein levels in plasma of Japanese flounder Paralichthys olivaceus. A basal diet was prepared with fish meal as primary protein source, the other diets were supplemented with 0·2, 0·4 or 0·8% phytic acid, 0·4, 0·8 or 1·5% stachyose, 0·1, 0·35 or 0·7% soy saponins and 0·10, 0·35 or 0·70% soy isoflavones, by dry mass, in place of white flour in the basal diet. Total cholesterol (TC) and triglyceride (TG) levels in plasma of P. olivaceus were not affected by phytic acid or stachyose. In general, addition of 0·2-0·8% phytic acid or 0·4-1·5% stachyose decreased plasma high-density lipoprotein cholesterol (HDL-C) levels, increased plasma low-density lipoprotein cholesterol (LDL-C) levels, thereby increasing the LDL-C:HDL-C ratio. By contrast, supplementation with 0·35-0·7% soy saponins generally depressed plasma TC levels and the LDL-C:HDL-C ratio. Supplementation with 0·35-0·7% soy isoflavones, however, increased plasma TC and TG levels. These results indicate that soy saponins may be partly responsible for the cholesterol-lowering effects of soybean meal.

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Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats

Cited by 11 publications

References 45 publications

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets

Effects of antinutritional factors on plasma lipoprotein levels in Japanese flounder Paralichthys olivaceus

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