Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats

Protective effect of quercetin on liver damage induced by biliary obstruction in rats

“…In BDL-QE rats, fibrosis was greatly reduced (Tieppo et al 2009). Likewise Tieppo et al andAksu et al's (2009, 2009) studies, we have found in our study that the positive stainings for a-SMA were greatly increased especially in vascular smooth muscle cells and sinusoids and also in the cells of portal ducts, fibrotic septa, perisinuses and around the proliferated bile ducts. The a-SMA positive cells in the BDL group were observed to be reduced with the QE treatment.…”

Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats

“…We have previously shown 2 μM used SPC can reduce the hepatic damage in extrahepatic cholestasis by prevention of the oxidative stress, and the inflammatory process in liver bile duct ligation. [19]. The contrary results suggest that the SPC-induced generation of ROS plays a crucial role in the cell death of endothelial cells through extracellular signal-regulated kinase-dependent pathways [29].…”

“…It was initially dissolved in 100% ethanol and the resulting SPC/ethanol solution was subsequently dissolved in a phosphate-buffered solution (PBS) containing 2 mg/ml and 10 mg/ml bovine serum albumin to acquire a stock solution (2 mM and 10 mM), as described in Aksu et al [19]. The SPC stock solution was stored at − 80°C.…”

“…oxygen species (ROS) [17], and providing potent anti-inflammatory effects [18,19]. The different biological effects of SPC are dependent on specific SPC concentrations [20].…”

Effect of antiretroviral drug (arved) on hepatic enzymes in albino rats

“…Intrahepatic cholestasis is a common manifestation of drug-induced liver injury in humans (Levy and Lindor, 2004;Lewis and Zimmerman, 1999) and is often the earliest manifestation of injury during liver transplant rejection (Lefkowitch, 2004). Similarly, transaminase increases are common in animal models of bile duct ligation (Aksu et al,2009) and can be seen in patients with cholelithiasis and cholecystitis in which transaminase increases are in part attributed to local bile acid-mediated cytotoxicity (Chang et al, 2009;Nathwani et al, 2005). Although cholestasis can exert local effects, cholestasis is also mechanistically related to hepatocellular necrosis and apoptosis through a variety of processes including but not limited to Fas-and tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL)-mediated activation of hepatocyte death receptors, bile acidmediated activation of mitochondrial pro-apoptotic pathways, and oxidative stress (Malhi et al,2006).…”