2014
DOI: 10.1590/s0100-69912014000200009
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Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"

Abstract: Gonçalves Gonçalves Gonçalves Gonçalves GonçalvesEffects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"Original Article Original Article Original Article Original Article Original Article Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of no… Show more

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Cited by 13 publications
(7 citation statements)
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“…This theory seemingly covers both the macrophage activity and the available splenic volume. In states of splenomegaly, overloaded splenic tissue exaggerates the impact of the splenic factor by phagocytosis, with dramatically rising storage volume for lipid, thus lowering serum lipid values [ 43 ], whereas in an asplenic or hyposplenic condition, this very mentioned factor is missed, the splenic parenchyma as well as the macrophage activity undergoes destruction, and the metabolic reactions meet with repercussion, thus improving lipid parameters [ 27 ]. However, this theory is unable to fully interpret the currently existent evidences of lipidic metabolic changes in splenic cells, thus necessitating an in-depth investigation into its innate cellular function.…”
Section: Introductionmentioning
confidence: 99%
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“…This theory seemingly covers both the macrophage activity and the available splenic volume. In states of splenomegaly, overloaded splenic tissue exaggerates the impact of the splenic factor by phagocytosis, with dramatically rising storage volume for lipid, thus lowering serum lipid values [ 43 ], whereas in an asplenic or hyposplenic condition, this very mentioned factor is missed, the splenic parenchyma as well as the macrophage activity undergoes destruction, and the metabolic reactions meet with repercussion, thus improving lipid parameters [ 27 ]. However, this theory is unable to fully interpret the currently existent evidences of lipidic metabolic changes in splenic cells, thus necessitating an in-depth investigation into its innate cellular function.…”
Section: Introductionmentioning
confidence: 99%
“…By this token, the spleen is not only dedicated to the production of anti-oxLDL antibodies, but also to the clearance of antigen-antibody complexes [ 43 ]. However, unexpectedly, there are also few documentations affirming exacerbation of atherosclerotic lesions with no differences in serum titers of anti-oxLDL antibodies after splenectomy [ 10 , 39 ].…”
Section: Introductionmentioning
confidence: 99%
“…There were also a few theories to explain the role of spleen in the regulation of plasma lipids. Spleen can influence lipid metabolism through the B lymphocytes which were capable of producing antioxidized-LDL antibodies and remove it from the circulation by tissue macrophages (Goncalves et al 2014). There was no effect on the level of total cholesterol, but there was decrease effect on triglycerides profile.…”
Section: Discussionmentioning
confidence: 99%
“…The level of total cholesterol and triglycerides are indicators used to diagnose damage regulation of lipid metabolism in the liver (Mandal et al 2013). But in some theories, lipid metabolism also can be influenced by spleen condition of hypersplenism and splenomegaly (Goncalves et al 2014).…”
Section: Introductionmentioning
confidence: 99%
“…For this reason, partial splenectomy has been performed for an increasing number of indications 1 . In addition to these primordial functions, it was demonstrated in an experimental study that the spleen has a role in the lipid metabolism of rats 2 . This result has not been demonstrated in mice 3 .…”
Section: Introductionmentioning
confidence: 99%