“…In relation to the diet, flavonoids have been described as promising plant-based bioactives capable of modulating different aspects of neuroplasticity, resulting in improvements in memory in both rodents [2] and humans [3,4]. For example, flavonoids have been correlated with their ability to modulate the phosphorylation state of intracellular proteins by the activation or inhibition of phosphoinositide 3-kinase (PI3K), protein kinase C (PKC), mitogenactivated protein kinase (MAP), CAMP responsive element binding protein 1 (CREB-1), growth associated protein 43 (GAP-43), brain-derived neurotrophic factor (BDNF), or to alter expression of N-methyl d-aspartic acid (NMDA) receptors (NMDARs), GABA A receptors (GABA A Rs), and 5-HT receptors (5-HTRs) [5,6]. In addition, flavonoids can modulate epigenetic modifications [7].…”