2003
DOI: 10.1016/s0014-4886(03)00136-5
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Effects of stimulus frequency and age on bidirectional synaptic plasticity in the dentate gyrus of freely moving rats

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Cited by 36 publications
(35 citation statements)
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“…This study determined that at the perforant-path/granule-cell synapse of adult control rats the crossover point is approximately 10 Hz (Fig. 1E), which is consistent with earlier results in the hippocampal DG (Blaise and Bronzino, 2003) and CA1 (van Dam et al, 2004), while a transient application of PREGS lowered systematically the frequency threshold to induce LTP, giving a crossover point of 3 Hz. This observation provides evidence that a transient increase in the PREGS level in the hippocampus can induce a metaplasticity.…”
Section: Postsynaptic Origin Of 20 Hz-ltp Inductionsupporting
confidence: 91%
See 1 more Smart Citation
“…This study determined that at the perforant-path/granule-cell synapse of adult control rats the crossover point is approximately 10 Hz (Fig. 1E), which is consistent with earlier results in the hippocampal DG (Blaise and Bronzino, 2003) and CA1 (van Dam et al, 2004), while a transient application of PREGS lowered systematically the frequency threshold to induce LTP, giving a crossover point of 3 Hz. This observation provides evidence that a transient increase in the PREGS level in the hippocampus can induce a metaplasticity.…”
Section: Postsynaptic Origin Of 20 Hz-ltp Inductionsupporting
confidence: 91%
“…The frequency-dependencies of LTP/LTD levels in control and LLP PREGS -slices are summarized by plotting the op-EPSP amplitudes at 55-60 min after CS delivery against CS frequency as shown in Figure 1E. In control slices a sigmoidal-shaped curve was constructed, which is similar to that predicted by the BCM model with a crossover point at 10 Hz (Bienenstock et al, 1982;Blaise and Bronzino, 2003). Notably, in the presence of LLP PREGS , the largest LTP and LTD were induced at 20-30 Hz and 0.5 Hz CS, respectively, resulting in a leftward shifted LTP/LTD-frequency curve with a crossover point at 3 Hz.…”
Section: Frequency-dependent Synaptic Plasticity In Slices Expressingmentioning
confidence: 78%
“…Disparate findings in in vivo versus in vitro preparations may be due to the absence of important afferents (locus coeruleus, dorsal and median raphe, and medial septum) in the hippocampal slice which provide neuromodulatory regulation of dentate granule cell excitability (Blaise and Bronzino, 2003;Bordi et al, 1997;Hargreaves et al, 1990). Commonly employed in vivo methodologies, including acute and chronic preparations, also present some drawbacks.…”
Section: In Vitro In Vivo Anesthetizedmentioning
confidence: 99%
“…Slice preparation is an adequate test system for further investigation into the cellular basis of anesthetic action. However, cutting brain slices disconnects the neurons from the sources of their afferences and from the targets of their efferent projections, eliminating the regulation of neuronal activity by serotoninergic projections mainly from the raphe, noradrenaline afferences from the locus coeruleus, acetylcholine innervation from the nucleus basalis, and hormonal modulations [17,18], all of which are crucially involved in LTP formation. In addition, several studies have demonstrated that GABA is involved in triggering the LTP phenomenon.…”
Section: Discussionmentioning
confidence: 99%