Purpose: The purpose of this study is to identify that emotional labor has effect on depressive symptom, job satisfaction, and moderating effect of self-esteem and ego-resilience of nurses.Methods: Data were collected by questionnaires from 224 nurses university hospitals from May 8 to May 19, 2017, analyzing by hierarchical multiple regression.Results: There was a significant positive correlation with emotional labor and depressive symptom. Also emotional labor was significant negative correlation with job satisfaction, self-esteem, and ego-resilience. Ego-resilience had a moderating effect that emotional labor affected depressive symptom and job satisfaction.Conclusion: In this study, Ego-resilience were found to have a significant moderating effect in relation to emotional labor, depressive symptom, and job satisfaction. Therefore, it's needed to consider the ego-resilience when developing emotional labor management program of nurses.