Effects of Stressor Predictability on Escape Learning and Sleep in Mice

Machida, Manabu; Yang, Linghui; Wellman, Laurie L.; Sanford, Larry D.

doi:10.5665/sleep.2464

Cited by 23 publications

(22 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others, based on positive correlations of REM amounts with fear recall in human subjects, have suggested that REM sleep deprivation be considered as a means to attenuate fear memory associated with distressing events. 48 We have found that REM can be either increased or decreased in association with specific stressor characteristics or experimental parameters of conditioned fear, 25 but neither increases nor decreases in REM alone are predictive of the expression of fear memory elicited by reexposure to the shock context. 10 However, consistent results of REM increase after controllable stress but not after uncontrollable stress 9,13 and in association with fear extinction in animal model 52 suggest critical roles of post-ST REM in fear regulation.…”

Section: Bla Involvement In Rem Regulationmentioning

confidence: 94%

“…Methods for fear conditioning and fear memory testing have been described in Machida et al 25 After baseline recordings were obtained, the mice were connected bilaterally to optic fiber cables and placed in a shock chamber (Coulbourn Instruments) for shock training (ST). DataWave Experimenter's Workbench (Data Wave Technologies, Loveland, CO) was used to control the timing and duration of footshock and light.…”

Section: Peri-shock Inhibition Of Bla In Vivomentioning

confidence: 99%

“…Sleep and wakefulness of the animals were visually scored by a trained observer based on EEG and activity in 10-s epochs using a scoring program (Sleep Sign for Animal, Kissei, Nagano, Japan) as described previously. 25,26 Briefly, each epoch was scored as wakefulness with moving (AW, with activity recorded in epoch), quiet wakefulness (QW, no activity during epoch), NREM, or REM. During NREM sleep, the EEG was characterized as high amplitude slow waves, while REM was characterized as regularly spaced lower amplitude wave and increased theta activity.…”

Section: Cortical Eeg Recording and Determination Of Behavioral Statementioning

confidence: 99%

See 2 more Smart Citations

Brief Optogenetic Inhibition of the Basolateral Amygdala (BLA) in Mice Alters Effects of Stressful Experiences on Rapid Eye Movement Sleep (REM)

Machida

Wellman

et al. 2017

Sleep

Self Cite

View full text Add to dashboard Cite

Study Objectives: Stressful events can directly produce significant alterations in subsequent sleep, in particular rapid eye movement sleep (REM); however, the neural mechanisms underlying the process are not fully known. Here, we investigated the role of the basolateral nuclei of the amygdala (BLA) in regulating the effects of stressful experience on sleep. Methods: We used optogenetics to briefly inhibit glutamatergic cells in BLA during the presentation of inescapable footshock (IS) and assessed effects on sleep, the acute stress response, and fear memory. c-Fos expression was also assessed in the amygdala and the medial prefrontal cortex (mPFC), both regions involved in coping with stress, and in brain stem regions implicated in the regulation of REM. Results: Compared to control mice, peri-shock inhibition of BLA attenuated an immediate reduction in REM after IS and produced a significant overall increase in REM. Moreover, upon exposure to the shock context alone, mice receiving peri-shock inhibition of BLA during training showed increased REM without altered freezing (an index of fear memory) or stress-induced hyperthermia (an index of acute stress response). Inhibition of BLA during REM under freely sleeping conditions enhanced REM only when body temperature was high, suggesting the effect was influenced by stress. Peri-shock inhibition of BLA also led to elevated c-Fos expression in the central nucleus of the amygdala and mPFC and differentially altered c-Fos activity in the selected brain stem regions. Conclusions: Glutamatergic cells in BLA can modulate the effects of stress on REM and can mediate effects of fear memory on sleep that can be independent of behavioral fear.

show abstract

Section: Bla Involvement In Rem Regulationmentioning

confidence: 94%

Section: Peri-shock Inhibition Of Bla In Vivomentioning

confidence: 99%

Section: Cortical Eeg Recording and Determination Of Behavioral Statementioning

confidence: 99%

See 1 more Smart Citation

Brief Optogenetic Inhibition of the Basolateral Amygdala (BLA) in Mice Alters Effects of Stressful Experiences on Rapid Eye Movement Sleep (REM)

Machida

Wellman

et al. 2017

Sleep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Increases in REM sleep were also observed in rabbits after handling, which led to more activity in successive open-field behavior assessment (Denenberg et al 1977). Rodent studies also showed increases in REM sleep episodes after learning in associative fear-related learning tasks, such as the fear-conditioning paradigm and an escapable shock task (Sanford et al 2010;Machida et al 2013;Menz et al 2013). REM sleep also increased in rodents after training in the Morris water maze paradigm Rose 1996, 1997).…”

Section: Sleep Enhances Memory Consolidationmentioning

confidence: 80%

The impact of sleep loss on hippocampal function

2013

View full text Add to dashboard Cite

Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are targeted by sleep deprivation to impair memory consolidation and plasticity. In this review, we address these topics with a focus on the detrimental effects of post-learning sleep deprivation on memory consolidation. Obtaining adequate sleep is challenging in a society that values "work around the clock." Therefore, the development of interventions to combat the negative cognitive effects of sleep deprivation is key. However, there are a limited number of therapeutics that are able to enhance cognition in the face of insufficient sleep. The identification of molecular pathways implicated in the deleterious effects of sleep deprivation on memory could potentially yield new targets for the development of more effective drugs.

show abstract

“…Activation of MR increases SWS, while activation of GR by dexamethasone increases wake [Born et al, 1989[Born et al, , 1991. Acute stress, for example, foot shock or immobilization [Machida et al, 2013;Vazquez-Palacios and Velazquez-Moctezuma, 2000], hydrocortisone, [Vazquez-Palacios et al, 2001] or chronic administration of corticosterone [Wang et al, 2014[Wang et al, , 2015 suppresses sleep and alters EEG architecture in animal models.…”

Section: Hpa Axis Hormones and Sleep Interactionsmentioning

confidence: 99%

The Molecular Basis of Insomnia: Implication for Therapeutic Approaches

Wang

Liu

2016

Drug Development Research

View full text Add to dashboard Cite

Preclinical Research Insomnia is one of the most common sleep disorders that is characterized by difficulty in sleep initiation, sleep maintenance, and/or poor sleep quality. Treatment for insomnia includes both pharmacological and non-pharmacological interventions. Recently, the development of pharmacological treatment for insomnia has been prompted by the understanding of the molecular neurobiology of sleep-wake regulation. For pharmacological treatment, benzodiazepines that target GABAergic system are the most widely used hypnotics. Besides GABA, the hypocretin/orexin system, and the hypothalamic-pituitary-adrenal (HPA) axis are involved in sleep-wake regulation and may also play important role in the pathogenesis of insomnia. Genetic studies have revealed the critical role of several important genes related to the above-mentioned systems in the regulation and function of sleep, suggesting the genetic/epigenetic factors could also contribute to the development and regulation of insomnia. Non-pharmacological interventions include cognitive behavioral therapy for insomnia (CBT-I) that is an effective insomnia treatment with less risk and side effects of drug therapy. Here the current treatments for insomnia based on the molecular mechanisms underlying sleep-wake regulation, were reviewed and some newer targets that may be beneficial in the development of new treatments for insomnia were discussed. Drug Dev Res 77 : 427-436, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Effects of Stressor Predictability on Escape Learning and Sleep in Mice

Abstract: Machida M; Yang L; Wellman LL; Sanford LD. Effects of stressor predictability on escape learning and sleep in mice. SLEEP 2013;36(3):421-430.

Cited by 23 publications

References 64 publications

Brief Optogenetic Inhibition of the Basolateral Amygdala (BLA) in Mice Alters Effects of Stressful Experiences on Rapid Eye Movement Sleep (REM)

Brief Optogenetic Inhibition of the Basolateral Amygdala (BLA) in Mice Alters Effects of Stressful Experiences on Rapid Eye Movement Sleep (REM)

The impact of sleep loss on hippocampal function

The Molecular Basis of Insomnia: Implication for Therapeutic Approaches

Contact Info

Product

Resources

About