Effects of Subchronic Parathion Exposure on Cyclosporine Pharmacokinetics in Rats

Gelal, Ayşe; Gümüştekin, Mukaddes; Kalkan, Şule; Guven, Hulya; Eminoglu, Ozlem

doi:10.1080/009841001459441

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…The OPT dose (0.14 mg/kg) was determined from our previous study (Gelal et al 2001). On the ninth day, each animal (the rats were fasted overnight before the experiments) was anesthetized with α-chloralose (130 mg/kg, IP).…”

Section: Methodsmentioning

confidence: 99%

Effect of Repeated Low-Dose Organophosphorothionate Pesticide Exposure on Digoxin Pharmacokinetics in Rats; a Possible Interaction Involving P-Glycoprotein

Yusuf

Oransay

Eminoglu³

et al. 2007

Toxicology Mechanisms and Methods

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Aside from acute occupational exposure, an important part of the population may be chronically exposed to the trace amounts of organophosphorothionate pesticides (OPTs) via residues in nutrients and drinking water. P-glycoprotein (P-gp) is a transmembrane protein responsible for the efflux of numerous drugs. OPTs were shown to inhibit P-gp function in vitro and increase its expression in vivo. Digoxin is a probe drug for the investigation of P-gp. To evaluate the effect of repeated low-dose OPT exposure on P-gp, commercial formulations of diluted OPT or tap water were administered to female Wistar rats for 8 consecutive days. On the ninth day each group was further divided into two groups and digoxin was administered either intraduodenally (ID) or intravenously (IV). Blood sampling and bile and urine collection were taken during 6 h at various intervals. The peak concentration in serum (C(max)) of digoxin was found to be decreased and the mean absorption time (MAT) was significantly increased in the digoxin OPT group. The mean residence time was significantly elevated in the digoxin(ID) OPT group. The biliary excretion% digoxin was significantly increased in the digoxin OPT group, while the renal excretion% digoxin rose only in the digoxin(ID) OPT group. No significant differences in time to reach C(max) (t(max)), area under the plasma concentration-time curve (AUC)(0-360), area under the moment curve (AUMC)(0-360), and bioavailability (F) were detected. In our study, repeated low-dose OPT exposure reduced the absorption and increased the excretion% digoxin, which may be related to enhanced P-gp expression. However, alterations of digoxin pharmacokinetic parameters did not change the systemic availability of digoxin.

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Section: Methodsmentioning

confidence: 99%

Effect of Repeated Low-Dose Organophosphorothionate Pesticide Exposure on Digoxin Pharmacokinetics in Rats; a Possible Interaction Involving P-Glycoprotein

Yusuf

Oransay

Eminoglu³

et al. 2007

Toxicology Mechanisms and Methods

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“…However, the majority of studies discuss the protective effect of vitamins or microelements with exposure to organophosphate insecticides (Verma et al 2007, Abdallach et al 2011 or the influence of mixtures of pesticides (El-Demerdash 2011, Ojha andSrivastava 2012). To the best of our knowledge a very limited number of investigations refer to the consequences caused by the co-administration of pesticides and medicaments (Gelal et al 2001, Babu et al 2006, Suarez et al 2014, and only individual ones focus on oxidative stress Spodniewska 2012, Spodniewska et al 2014). …”

Section: Group Of Animalsmentioning

confidence: 99%

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Spodniewska¹,

Barski²

2016

Polish Journal of Veterinary Sciences

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The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD 50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i.e. on day 24, 25, 26, 27 and 28). Chlorpyrifos and enrofloxacin were administered to rats intragastrically via a gastric tube. The quantitative determination of vitamins was made by the HPLC method. The results of this study indicated a reduction in the hepatic concentrations of vitamins A and E, compared to the control, which sustained for the entire period of the experiment. The four-week administration of chlorpyrifos to rats resulted in a significant decrease of vitamins in the initial period of the experiment, i.e. up to 24 hours after exposure. For vitamin A the maximum drop was observed after 24 hours (19.24%) and for vitamin E after 6 hours (23.19%). Enrofloxacin caused a slight (3-9%) reduction in the level of the analysed vitamins. In the chlorpyrifos-enrofloxacin co-exposure group reduced vitamins A and E levels were also noted, but changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only. The decrease in the antioxidant vitamin levels, particularly noticeable in the chlorpyrifos-and the chlorpyrifos combined with enrofloxacin-treated groups, may result not only from the increase in the concentration of free radicals, but also from the intensification of the secondary stages of lipid peroxidation.

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Interaction of Anticholinesterase Pesticides with Metals

Malik

Telang

Kumar

et al. 2011

Anticholinesterase Pesticides

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Effects of Subchronic Parathion Exposure on Cyclosporine Pharmacokinetics in Rats

Cited by 7 publications

References 8 publications

Effect of Repeated Low-Dose Organophosphorothionate Pesticide Exposure on Digoxin Pharmacokinetics in Rats; a Possible Interaction Involving P-Glycoprotein

Effect of Repeated Low-Dose Organophosphorothionate Pesticide Exposure on Digoxin Pharmacokinetics in Rats; a Possible Interaction Involving P-Glycoprotein

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Interaction of Anticholinesterase Pesticides with Metals

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