Effects of Subinhibitory Concentrations of Ibuprofen Isobuthanolammonium on Virulence Factors of Uropathogenic<i>Escherichia coli</i>

Drago, Lorenzo; Vecchi, Elena De; Nicola, L.; Valli, M.; Gismondo, Maria Rita

doi:10.1179/joc.2002.14.3.314

Cited by 14 publications

(8 citation statements)

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“…Another example is that two thirds of women with uncomplicated urinary tract infections (80% with E. coli) treated with ibuprofen recover without antibiotics (95). Although this finding is considered to result from the anti-inflammatory effects of ibuprofen, it might also be attributable to the antimicrobial effects of ibuprofen, which include blocking of adherence to uroepithelial cells, reduced motility, and reduced toxin and biofilm production, as well as inhibition of growth (9,25,26). Diclofenac and other NSAIDs inhibit bacterial DNA synthesis (10,91) in E. coli; this was shown to be through the inhibition of a DNA polymerase (96).…”

Section: Discussionmentioning

confidence: 96%

“…and E. coli (9,16,28). This could be helpful in the treatment of infections in the presence of foreign material, especially intravenous or urine catheters.…”

Section: Discussionmentioning

confidence: 99%

“…Fungi (unlike bacteria and viruses) produce prostaglandins, and although their exact function is uncertain, it is thought that they influence virulence, in particular controlling the yeast-to-hypha transition and biofilm production (32,34,81). Aside from prostaglandin inhibition, as detailed in this review, other mechanisms by which antipyretic drugs influence pathogens include inhibiting virus replication (75)(76)(77)(78)(79), inhibiting or promoting bacterial and fungal growth (1-3, 5-9, 16-21, 34, 45, 52, 82-85), altering the expression of virulence factors (5,6,9,29,30,37,39,(43)(44)(45), changing the surface hydrophobicity of microbes (9), influencing biofilm production (16,21,30,32,33,35,(37)(38)(39)(40)(41), affecting motility (22,23), adherence (9,16,(25)(26)(27)(28)(29)(30)(31), and metabolism (16,18,46), interacting with the transport and release of antibiotics by PMNL …”

Section: Discussionmentioning

confidence: 99%

“…Ibuprofen at a very low concentration (0.002 mg/ml) significantly decreases the adhesion of E. coli to uroepithelial cells ( Table 2). This results from reduced fimbria production, as well as changes in surface hydrophobicity influencing the interaction between bacterial and host cells (9,25,26). Ibuprofen also reduces the adherence of E. coli to silastic catheters (27).…”

mentioning

confidence: 99%

“…In H. pylori, ASA and indomethacin reduce urease and vacuolating cytotoxin activities (5,45). Ibuprofen, at low concentrations, reduces hemolysin production in E. coli (9).…”

mentioning

confidence: 99%

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Antimicrobial Effects of Antipyretics

Zimmermann

Curtis

2017

Antimicrob Agents Chemother

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Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote bacterial or fungal growth, alter the expression of virulence factors, change the surface hydrophobicity of microbes, influence biofilm production, affect the motility, adherence, and metabolism of pathogens, interact with the transport and release of antibiotics by leukocytes, modify the susceptibility of bacteria to antibiotics, and induce or reduce the frequency of mutations leading to antimicrobial resistance. While antipyretics may compromise the efficacy of antimicrobial therapy, they can also be beneficial, for example, in the management of biofilm-associated infections, in reducing virulence factors, in therapy of resistant pathogens, and in inducing synergistic effects. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, targeting virulence factors, enhancing the efficacy of antimicrobial therapy, and reducing resistance may be important strategies.

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Section: Discussionmentioning

confidence: 96%

“…and E. coli (9,16,28). This could be helpful in the treatment of infections in the presence of foreign material, especially intravenous or urine catheters.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…In H. pylori, ASA and indomethacin reduce urease and vacuolating cytotoxin activities (5,45). Ibuprofen, at low concentrations, reduces hemolysin production in E. coli (9).…”

mentioning

confidence: 99%

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