Effects of substituents on activation parameter changes in the Michael-type reactions of nucleophilic addition to activated alkenes and alkynes in solution

Stability of strigolactone analog GR24 toward nucleophiles

“…Generally, the Michael reaction constitutes one of the most versatile methods in organic synthesis for the construction of new carbon–carbon or carbon‐heteroatom bonds, through a well‐established mechanism . The kinetic and activation parameters obtained for this reaction concur with those presented in the literature …”

Enthalpy–Entropy Compensation Effect in Chemical Kinetics and Experimental Errors: A Numerical Simulation Approach

“…Effectively, it has been observed in Figure that an enthalpy–entropy compensation effect is found even when there is no real correlation between the activation parameters, provided that the accidental errors associated with the determination of the rate constants are high enough. Although some authors have published useful tools for this purpose, ,, the search for a different alternative, potentially providing further quantitative information, seems attractive enough. Thus, the following goal of this research will be the elaboration of a test capable of discerning whether a certain activation enthalpy–entropy linear relationship found in the laboratory can be explained by the occurrence of experimental errors or not.…”

“…Several methods have been previously proposed to discriminate error-induced compensation plots from those with a real physical origin. ,,,,, These methods can be regarded as complementary, often leading to coherent results. However, the one now presented ( p -test) might be more intuitive, because it yields a parameter with a direct physical interpretation: the probability of an isokinetic relationship found for a particular homologous reaction series being explainable as a consequence of random experimental errors.…”