Effects of sulfur dioxide, ozone, and ambient air pollution on bone
metabolism related biochemical parameters in a rat model

Kheirouri, Sorayya; Alizadeh, Mohammad; Abad, Razieh Musapour Sultan; Barkabi-Zanjani, Sona; Abbasi, Mehran Mesgari

doi:10.5620/eaht.2020023

Cited by 12 publications

(10 citation statements)

References 24 publications

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“…10 Our ndings have also been now con rmed in multiple human studies [11][12][13][14][15][16] and are supported by animal studies. 17 We have also con rmed the effect of exposure to several air pollutants on reduced BMD and fractures in postmenopausal women. 18 Recent human studies show that even low concentrations of ambient air pollution can affect the levels of several metabolites 19,20 that affect bone-related metabolites such as αtocopherol 21,22 and glycine.…”

Section: Introductionmentioning

confidence: 58%

Metabolomic Evaluation of Air Pollution-related Bone Damage and Potential Mediation

Prada

Rexrode

Kalia

et al. 2023

Preprint

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Ambient air pollution has been associated with bone damage. However, no studies have evaluated the metabolomic response to air pollutants and its potential influence on bone health in postmenopausal women. We analyzed data from WHI participants with plasma samples. Whole-body, total hip, femoral neck, and spine BMD at enrollment and follow-up (Y1, Y3, Y6). Daily particulate matter NO, NO2, PM10 and SO2 were averaged over 1-, 3-, and 5-year periods before metabolomic assessments. Statistical analyses included multivariable-adjusted linear mixed models, pathways analyses, and mediation modeling. NO, NO2, and SO2, but not PM10, were associated with taurine, inosine, and C38:4 phosphatidylethanolamine (PE), at all averaging periods. We found a partial mediation of C38:4 PE in the association between 1-year average NO and lumbar spine BMD (p-value: 0.032). This is the first study suggesting that a PE may partially mediate air pollution-related bone damage in postmenopausal women.

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Section: Introductionmentioning

confidence: 58%

Metabolomic Evaluation of Air Pollution-related Bone Damage and Potential Mediation

Prada

Rexrode

Kalia

et al. 2023

Preprint

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“…yielded no noteworthy differentiation in β-CTX levels between adolescents inhabiting polluted and unpolluted locales ( 54 ). A basic study found that rats exposed to air pollutants had significantly higher ALP levels than the control group ( 55 ). There was limited research on the correlation between air pollution and PINP, which made it challenging to compare our current findings with previous research.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

Zhang,

Shi,

Yuan

et al. 2024

Front. Endocrinol.

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IntroductionThe correlation between the non-use of cooking oil fumes (COFs) extractors and bone mineral density (BMD) have not been clarified. Consequently, this study attempted to explore the impact of non-use COFs extractors on BMD in population aged 45 years and older based on a cross-sectional study.MethodsThis study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study in China. The multivariate linear regression models were used to evaluate the correlation between the non-use of fume extractors in family cooking and total lumbar spine (LS), femoral neck (FN), total hip BMD and levels of bone metabolism markers.ResultsA total of 3433 participants were included in the final analyses, of which 2607 (75.93%) participants used fume extractors. The results of models indicated that there were significant correlations of the non-use of fume extractors on total LS BMD (β = -0.024, 95% CI, -0.036, -0.012, p < 0.001), PINP (β = 4.363, 95% CI, 2.371, 6.356, p < 0.001) and ALP (β = 4.555, 95% CI, 2.593, 6.517, p < 0.001) levels.ConclusionsThis study verified that the use of fume extractors is an efficacious measure to prevent LS bone loss. For the sake of public bone health, people should install a fume extractor in the kitchen and use it routinely when cooking.

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“…Environmental toxins such as dioxins, bisphenols, polychlorobiphenyls, phthalates, poly- and perfluoroalkyl, parabens, particulate matter (PM), and heavy metals can impact bone health by interfering with bone homeostasis through a variety of processes [ 98 , 99 , 100 , 101 , 102 ]. These include hormonal imbalance, direct osteoblast toxicity, and enhancement of osteoclast activity, leading to different bone-related ailments.…”

Section: Intrinsic and Extrinsic Variables Affecting Bone Healthmentioning

confidence: 99%

From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease

Singh,

Sarma,

Verma

et al. 2023

Medicina

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The skeletal system is an extraordinary structure that serves multiple purposes within the body, including providing support, facilitating movement, and safeguarding vital organs. Moreover, it acts as a reservoir for essential minerals crucial for overall bodily function. The intricate interplay of bone cells plays a critical role in maintaining bone homeostasis, ensuring a delicate balance. However, various factors, both intrinsic and extrinsic, can disrupt this vital physiological process. These factors encompass genetics, aging, dietary and lifestyle choices, the gut microbiome, environmental toxins, and more. They can interfere with bone health through several mechanisms, such as hormonal imbalances, disruptions in bone turnover, direct toxicity to osteoblasts, increased osteoclast activity, immune system aging, impaired inflammatory responses, and disturbances in the gut–bone axis. As a consequence, these disturbances can give rise to a range of bone disorders. The regulation of bone’s physiological functions involves an intricate network of continuous processes known as bone remodeling, which is influenced by various intrinsic and extrinsic factors within the organism. However, our understanding of the precise cellular and molecular mechanisms governing the complex interactions between environmental factors and the host elements that affect bone health is still in its nascent stages. In light of this, this comprehensive review aims to explore emerging evidence surrounding bone homeostasis, potential risk factors influencing it, and prospective therapeutic interventions for future management of bone-related disorders.

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Effects of sulfur dioxide, ozone, and ambient air pollution on bone metabolism related biochemical parameters in a rat model

Cited by 12 publications

References 24 publications

Metabolomic Evaluation of Air Pollution-related Bone Damage and Potential Mediation

Metabolomic Evaluation of Air Pollution-related Bone Damage and Potential Mediation

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease

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