1994
DOI: 10.1254/jjp.64.273
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Effects of SUN 8399, a Potent and Selective 5-HT1A Agonist, on Conflict Behavior and Ambulatory Activity in Mice: Comparison with Those of Buspirone, Tandospirone and Diazepam

Abstract: ABSTRACT-Behavioral effects of p.o. administration of SUN 8399, a selective 5-HTIA agonist, on the operant behavior under a MULT VI 1.5 min/FR 5-punishment schedule of food reinforcement and on the ambulatory activity were evaluated in mice, and the characteristics were compared with those of other 5-HT1A agonists, buspirone and tandospirone, and the benzodiazepine diazepam. Diazepam (3 and 10 mg/kg) significantly increased the punished response without eliciting any significant change in the non punished resp… Show more

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Cited by 12 publications
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“…1,4-Benzoxazepines are an important class of heterocyclic compounds with a wide range of biological activities . For example, rocastine ( A ) shows good antihistaminic activity; I-CBP112 ( B ) is a potent inhibitor of bromodomain–acetyl-lysine interaction; and SUN 8399 ( C ) is a selective 5-hydroxytryptamine agonist (see Figure ).…”
mentioning
confidence: 99%
“…1,4-Benzoxazepines are an important class of heterocyclic compounds with a wide range of biological activities . For example, rocastine ( A ) shows good antihistaminic activity; I-CBP112 ( B ) is a potent inhibitor of bromodomain–acetyl-lysine interaction; and SUN 8399 ( C ) is a selective 5-hydroxytryptamine agonist (see Figure ).…”
mentioning
confidence: 99%