Effects of super-hard rice bread blended with black rice bran on amyloid β peptide production and abrupt increase in postprandial blood glucose levels in mice

Nakamura, Sumiko; Hara, Takashi; Joh, Toshio; Kobayashi, Atsushi; Yamazaki, A.; Kasuga, Kensaku; Ikeuchi, Takeshi; Ohtsubo, Ken’ichi

doi:10.1080/09168451.2016.1240605

Cited by 22 publications

(21 citation statements)

References 57 publications

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“…And after cooking, only HPT KO showed BACE1 inhibitory activity (12.0%) although Koshihikari polished rice did not show BACE1 inhibitory activity. These results indicate that the BACE1 inhibitory activity of pigmented rice bran is much stronger than that of ordinary rice bran, as we reported in our previous paper [12] . Physical properties of cooked rice: As shown in Table 2, the physical properties of cooked rice were measured in bulk using a Tensipresser.…”

Section: Resultssupporting

confidence: 86%

“…Positive health effects from these pigments in the bran layer of rice have been reported; red and black rice decreased atherosclerotic plaque formation and increased the antioxidant status in rabbits due to an enhanced serum high-density lipoprotein cholesterol and apolipoprotein A1 concentration [11] . We prepared super-hard rice bread blended with black rice bran, which contained a high amount of RS, and demonstrated its strong inhibitory activity against β-secretase (BACE1) and acetylcholinesterase even after heating [12] .…”

Section: Introductionmentioning

confidence: 99%

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Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Ohtsubo¹,

Nakamura²,

Hara³

et al. 2018

JDO

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Type-2 diabetes and Alzheimer's disease are very serious diseases and the former has been suggested to be one of the causes of the latter. Low glycemic index foods inhibit rapid increases in blood glucose and insulin secretion after meals. In this study, we investigated the palatability of boiled rice and inhibition of an abrupt increase in blood glucose level (BGL) and amyloid β peptide production after eating blend of ordinary unpolished rice, "Koshihikari" and anthocyanin-rich blackrice, "Okunomurasaki" unpolished rice cooked after a high-pressure treatment (HPT KO). "Okunomurasaki" showed a high antioxidant capacity and high inhibitory activity against β-secretase even after HPT and cooking. A randomized, single-blind, crossover-designed study was conducted using 15 subjects with a normal BGL. BGLs at 90 and 120 min after ingesting the cooked HPT KO were significantly lower than that for cooked Koshihikari polished rice (p < 0.05). Furthermore, the increase in the amyloid β40 peptide in the blood 120 min after eating HPT KO tended to be lower than that of cooked Koshihikari polished rice. It would be necessary to conduct a long-term test using the present HPT KO in terms of inhibitory activity against the abrupt increase of BGL and amyloid β peptide production for the probability to prevent type-2 diabetes and Alzheimer's disease.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Ohtsubo¹,

Nakamura²,

Hara³

et al. 2018

JDO

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“…BR extract is also rich in polyphenols with anthocyanins, which have no toxic effects at doses ≤20 mg/kg/day in rat and 25 mg/kg/day in mice (43). Previous studies have reported that bread containing BR contributes to the reduction of Aβ peptide concentrations in the plasma of aged mice (44). In addition, BR and its constituent, cyanidin, have been shown to attenuate Aβ-induced neuronal cell death via modulation of the mitochondrial death pathway in SK-N-SH cells (45).…”

Section: Discussionmentioning

confidence: 98%

Beneficial effect of black rice (Oryza sativa L. var. japonica) extract on amyloid β‑induced cognitive dysfunction in a mouse model

et al. 2020

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Alzheimer's disease (AD) is an age-dependent progressive neurodegenerative disease, resulting in memory loss and cognitive dysfunction. The accumulation of amyloid β (Aβ) has been identified as the most important risk factor for AD. Black rice (BR; Oryza sativa L. var. japonica), which is widely consumed in Asia, is a good source of bioactive compounds including anthocyanins. Therefore, the aim of the present study was to evaluate the protective effect of BR extracts against Aβ 25-35-induced memory impairment in an in vivo AD mouse model. After intracerebroventricular injection of Aβ 25-35 , mice were treated with BR extract supplementation for 14 days. Memory and cognition function were evaluated over this period in both treated and untreated animals using T-maze, novel object recognition and Morris water maze tests. After behavioral tests, malondialdehyde (MDA) and nitric oxide (NO) concentrations in brain, liver and kidney tissues were analyzed. Mice treated with Aβ 25-35 had impaired memory and cognitive function; however, mice administered BR extract (100 mg/kg/day) demonstrated an improvement in cognition and memory function compared with the Aβ 25-35-injected control group. Furthermore, injection of Aβ 25-35 significantly increased MDA and NO generation in the brain, liver and kidney of mice. However, the group administered with BR extract had significantly inhibited lipid peroxidation and NO generation in the brain, liver and kidney. In addition, the protective effect of BR on lipid peroxidation and NO production by Aβ 25-35 was stronger in the brain compared with other tissues. Collectively, these findings suggested that BR supplementation may prevent memory and cognition deficits caused by Aβ 25-35-induced oxidative stress.

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“…In previous studies, we found that a super-hard rice bread blended with black rice bran (SRBBB), which contained a high amount of resistant starch (RS), provided a strong inhibitory activity against β-secretase (BACE1) and acetylcholinesterase, even after heating. Furthermore, aged mice fed the SRBBB diet for 4 weeks showed lower amyloid β40 peptide in their blood than mice fed a commercial feed diet [38].…”

Section: Introductionmentioning

confidence: 92%

Potential for Preventing Diabetes and Dementia by Consuming Unpolished Rice Blended with Black Unpolished Rice and Super-Hard Rice

Nakamura

Hara

Yamazaki

et al. 2019

BJSTR

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Type-2 diabetes, which may prompt Alzheimer's disease, can be regulated by diet. We investigated the palatability and efficacy of consuming two diets rich in β-glucan or resistant starch by blending ordinary polished rice and polished waxy barley (5:5) or by blending ordinary unpolished rice, unpolished pigmented rice and polished super-hard rice (2:4:4), then subjecting the blends to high-pressure treatment before cooking. After subjects consumed these diets for 12 weeks, consumers of the former rice blend had significantly less body fat, lower blood glucose levels. The latter blend showed higher antioxidant capacity and inhibition against β-secretase than control, and the subjects, consuming the latter blend, showed not only lower blood glucose levels, but also a higher ratio of amyloid β 42/40 peptide than the subjects consuming the traditional rice diet. Long-term consumption of the latter blended rice diets might inhibit rises in postprandial blood glucose levels and impede amyloid β production.

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Effects of super-hard rice bread blended with black rice bran on amyloid β peptide production and abrupt increase in postprandial blood glucose levels in mice

Cited by 22 publications

References 57 publications

Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Beneficial effect of black rice (<em>Oryza</em> <em>sativa</em> <em>L</em>. var. <em>japonica</em>) extract on amyloid β‑induced cognitive dysfunction in a mouse model

Potential for Preventing Diabetes and Dementia by Consuming Unpolished Rice Blended with Black Unpolished Rice and Super-Hard Rice

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Effects of super-hard rice bread blended with black rice bran on amyloid β peptide production and abrupt increase in postprandial blood glucose levels in mice

Cited by 22 publications

References 57 publications

Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Trial for the Development of Bio-Functional Foods to Prevent Diabetes and Dementia Using a High-Pressure Treatment

Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model

Potential for Preventing Diabetes and Dementia by Consuming Unpolished Rice Blended with Black Unpolished Rice and Super-Hard Rice

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Product

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Beneficial effect of black rice (<em>Oryza</em> <em>sativa</em> <em>L</em>. var. <em>japonica</em>) extract on amyloid β‑induced cognitive dysfunction in a mouse model