Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

Farsi, Payam Farahbakhsh; Djazayery, Abolghassem; Eshraghian, Mohammad Reza; Koohdani, Fariba; Saboor-Yaraghi, Ali Akbar; Derakhshanian, Hoda; Zarei, Mahnaz; Javanbakht, Mohammad Hassan; Djalali, Mahmoud

doi:10.1590/0004-2730000002861

Cited by 29 publications

(10 citation statements)

References 34 publications

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“…In subgroup analysis, among participants with metabolic disorders, fish oil supplementation could reduce the risk of insulin resistance by 47%. Our results were consistent with the meta-analysis reported in 2011 showing that fish oil supplementation had no effects on insulin sensitivity; however, among participants with metabolic syndrome, fish oil is associated with lower risk of insulin resistance [16, 40]. Participants in the meta-analysis were only healthy people and T2DM people; therefore, an important group of patients with metabolic disorders was neglected in the research.…”

Section: Discussionsupporting

confidence: 90%

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Geng²,

et al. 2017

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BackgroundFish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity.MethodsWe searched the Cochrane Library, PubMed, Embase database for the relevant studies update to Dec 2016. Two researchers screened the literature independently by the selection and exclusion criteria. Studies were pooled using random effect models to estimate a pooled SMD and corresponding 95% CI. This meta-analysis was performed by Stata 13.1 software.ResultsA total of 17 studies with 672 participants were included in this meta-analysis study after screening from 498 published articles found after the initial search. In a pooled analysis, fish oil supplementation had no effects on insulin sensitivity compared with the placebo (SMD 0.17, 95%CI -0.15 to 0.48, p = 0.292). In subgroup analysis, fish oil supplementation could benefit insulin sensitivity among people who were experiencing at least one symptom of metabolic disorders (SMD 0.53, 95% CI 0.17 to 0.88, p < 0.001). Similarly, there were no significant differences between subgroups of methods of insulin sensitivity, doses of omega-3 polyunsaturated fatty acids (n-3 PUFA) of fish oil supplementation or duration of the intervention. The sensitivity analysis indicated that the results were robust.ConclusionsShort-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders.

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Section: Discussionsupporting

confidence: 90%

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Geng²,

et al. 2017

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“…PUFAs was significantly associated with FBP, HDL-C and SBP. Food rich in PUFA increases insulin sensitivity [ 50 ], glucose utilization and decreases insulin resistance and the risk of type 2 diabetes [ 51 ]. These results shows that PUFAs improves MetS risk factors.…”

Section: Discussionmentioning

confidence: 99%

The risk of metabolic syndrome as a result of lifestyle among Ellisras rural young adults

et al. 2018

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The study aimed to investigate the association between metabolic syndrome (MetS) and lifestyle risk factors among Ellisras adults. A cross-sectional study was conducted on 624 adults (306 males and 318 females). MetS was defined according to the criteria of the International Diabetes Federation. The prevalence of MetS was 23.1% (8.6% males and 36.8 % females). Females appeared to have higher mean values for waist circumference (WC), fasting blood glucose (FBG), total cholesterol (TCHOL) and low-density lipoprotein cholesterol (LDL-C), while males had high mean values for high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No significant age and gender differences were observed for dietary intake. Significantly more females (51.9%) presented with increased WC than males (4.6%). Participants who had a high dietary energy intake were significantly less likely to present with larger WC (OR: 0.250 95% CI [0.161; 0.389]), low HDL-C (OR: 0.306 95% CI [0.220; 0.425]) and high LDL-C (OR: 0.583 95% CI [0.418; 0.812]) but more likely to present with elevated FBG (OR: 1.01 95% CI [0.735; 1.386]), high TCHOL (OR: 1.039 95% CI [0.575; 1.337]), high TG (OR: 1.186 95% CI [0.695; 2.023]) and hypertension (OR: 5.205 95% CI [3.156; 8.585]). After adjusting for age, gender, smoking, and alcohol status, high energy intake was more than two times likely to predict MetS in adults with a large WC (OR: 2.766 95% CI [0.863; 3.477] and elevated FBG (OR: 2.227 95% CI [1.051; 3.328]). Therefore, identifying groups that are at an increased risk and those that are in their early stages of MetS will help improve and prevent the increase of the MetS in the future.

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“…[ 46 ] Therefore, high n-6 PUFA and high n-6/n-3 ratio can contribute to the increased incidence of diabetes mellitus, MS, and coronary heart disease. On the other hand, n-3PUFA increases insulin sensitivity,[ 47 ] glucose utilization, decreases insulin resistance and risk of type 2 diabetes,[ 48 ] and also inhibit the production of inflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor-α,[ 49 ] thereby lowering the risk of MS. However, multiple mechanisms could be involved in these effects; particularly, there appears to be a modulation of gene expression by fatty acids, which influences obesity and insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Dietary fat intake and its association with risk of selected components of the metabolic syndrome among rural South Indians

Narasimhan¹,

Lakshmipriya²,

Vaidya³

et al. 2016

Indian J Endocr Metab

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Context:There is limited literature on the dietary fat intake of rural Indian populations, particularly in relation to the risk of metabolic syndrome (MS).Aim:This study aims to assess the dietary fat intake and analyze its association with the risk of selected components of the MS among rural population in the state of Tamil Nadu.Settings and Design:Adults (n = 27012) ≥20 years of age were recruited from the rural component of the Chennai Urban Rural Epidemiological Study, a cross-sectional study conducted in 42 villages in Kanchipuram District of Tamil Nadu.Subjects and Methods:Using a validated food frequency questionnaire, data were obtained on the fat intake among 6907 adults. Anthropometric and clinical measures were collected using standard methods. The components of the MS assessed were abdominal obesity, hypertension, and impaired fasting glucose. All analyses were performed using SPSS software (version 20).Results:Prevalence of abdominal obesity, hypertension, and impaired fasting glucose were significantly higher in the highest quintile of fat intake (33%, P < 0.001; 39%, P = 0.04, and 23.3%, P = 0.003, respectively). Highest intake of fat was also significantly associated with risk of abdominal obesity (P < 0.001), hypertension (P = 0.04), and impaired fasting glucose (P = 0.01). Sunflower oil as the main cooking oil was significantly associated with a higher risk of these components of the MS (P for trend <0.001) compared to traditional oils and palmolein.Conclusions:Higher dietary fat was significantly associated with risk of components of the MS and use of sunflower oil as main cooking oil increased metabolic risk in rural South Indians.

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Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

Cited by 29 publications

References 34 publications

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

The risk of metabolic syndrome as a result of lifestyle among Ellisras rural young adults

Dietary fat intake and its association with risk of selected components of the metabolic syndrome among rural South Indians

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