Effects of Suramin on HTLV-Iii/Lav Infection Presenting as Kaposi's Sarcoma or Aids-Related Complex: Clinical Pharmacology and Suppression of Virus Replication in Vivo

Broder, Samuel; Collins, JerryM; Pd, Markham; Redfield, R.; Hoth, DanielF; Groopman, JeromeE.; Gallo, RobertC.; Yarchoan, Robert; Lane, H. Clifford; Klecker, RaymondW; Mitsuya, Hiroaki; Gelmann, Edward P.; Resnick, Lionel; Myers, C. E.; As, Fauci

doi:10.1016/s0140-6736(85)90002-9

Cited by 190 publications

(41 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…74 it also has an inhibitory effect on the RT activity of retroviruses and has been used in patients with HiV infection. 75 Suramin inhibits RT by interacting with the template-primer binding site of the enzyme. It competitively binds to the primer binding site and inhibits the template-primer binding that is necessary for DNA prolongation; thus, suramin can be classified as a non-nucleoside RT inhibitor.…”

Section: Suraminmentioning

confidence: 99%

“…76 Suramin is associated with a significant number of severe side effects in humans: nausea and anaphy lactic shock as immediate reactions during administration; peripheral neuritis leading to palmar-plantar hyperaesthesia, photophobia, skin reactions, agranulocytosis, haemolytic anaemia and destruction of the adrenal cortex as later side effects. 74,75,[77][78][79] Severe side effects have to be expected in cats as well.…”

Section: Suraminmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Hartmann

2015

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

Section: Suraminmentioning

confidence: 99%

Section: Suraminmentioning

confidence: 99%

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Hartmann

2015

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…In addition to its antiparasitic and antitumor properties, suramin has been shown to strongly inhibit duck hepatitis B virus (DHBV) DNA polymerase (19,20) and the reverse transcriptase activities of a number of retroviruses (3), including the human immunodeficiency virus (13). A clinical trial in 10 patients with AIDS demonstrated that suramin indeed inhibits human immunodeficiency virus replication; immunological parameters and clinical outcomes were not affected, however (1).…”

mentioning

confidence: 99%

Suramin prevents duck hepatitis B virus infection in vivo

Offensperger

Walter

et al. 1993

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The effect of suramin on duck hepatitis B virus (DHBV) infection was investigated in vivo. Suramin pretreatment of Pekin ducklings completely prevented DHBV infection. In contrast, suramin given at the time of or after inoculation with DHBV did not inhibit viral infection, replication, or gene expression. These data indicate that suramin effectively blocks the early stages of DHBV infection in vivo.Suramin, a polysulfonated naphthylurea, was the first clinically useful antiparasitic drug and is still one of the most commonly used antitrypanosomal agents. Apart from its antiparasitic effects, suramin has been demonstrated to have a number of biochemical activities (7). Most notably, suramin has been shown to inhibit a number of enzymes, such as hexokinase, lysozyme (11), thrombin, plasma kallikrein (5), and protein kinase C (6). Since suramin was shown to bind to a number of growth factors (8) and protein kinase C is involved in tumor promotion and differentiation, the antitumor activity of suramin has been studied in patients with metastatic adrenocortical carcinoma (18) and metastatic prostate cancer (9). In addition to its antiparasitic and antitumor properties, suramin has been shown to strongly inhibit duck hepatitis B virus (DHBV) DNA polymerase (19,20) and the reverse transcriptase activities of a number of retroviruses (3), including the human immunodeficiency virus (13). A clinical trial in 10 patients with AIDS demonstrated that suramin indeed inhibits human immunodeficiency virus replication; immunological parameters and clinical outcomes were not affected, however (1).After the discovery of DHBV (12), Pekin ducks have become a widely used animal model to study hepadnaviral infection. By using this model, antiviral agents can be studied in vitro in replicative complexes isolated from DHBV-infected livers (16) or in primary duck hepatocyte cultures (18) as well as in vivo in DHBV-infected Pekin ducks (15). In primary duck hepatocyte cultures, suramin blocks infection when it is present before and during incubation of the cells with DHBV (17). Since suramin inhibits DHBV infection in vitro, we tested the effect of suramin on DHBV infection in vivo.Pekin ducks were used as an in vivo model of DHBV infection. One-day-old ducklings were purchased from a German duck farm. Blood was taken from the foot vein and was tested for the presence of DHBV DNA by dot blot hybridization (14). DHBV DNA-negative ducklings were infected at the age of 2 or 3 days by intravenous injection of 100 ,ul of DHBV-positive serum (about 109 virions per ml).

show abstract

“…Suramin was orighally synthesized in 1916 by the Bayer Company and since then has been routinely used as an effective treatrnent for trypanosorniasis and onchocerciasis (194). More recently, the ability of surarnin to inhibit reverse transcriptase, the DNA polymerase of retroviruses, and block the infection and cytopathic effect of HIV in vitro prompted its use in clinical AlDS trials (195,196).…”

Section: Suraminmentioning

confidence: 99%