Effects of surgery, anesthesia and intraoperative blood loss on immunocompetence

Jubert, Andre V.; Lee, Elisa T.; Hersh, Evan M.; McBride, Charles M.

doi:10.1016/0022-4804(73)90110-8

Cited by 125 publications

(31 citation statements)

References 12 publications

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“…Demographic and medical information were collected by self-report questionnaires and verified through medical record review. Based on previous research, data on potential confounding variables were collected including age, stage of disease, and time since surgery (Andersen et al, 1998;Jubert, Lee, Hersh, & McBride, 1973). Staging was based on the final surgical pathology report and determined by the TNM (tumor size, node involvement, and metastasis status) criteria of the American Joint Committee on Cancer (1997).…”

Section: Instrumentsmentioning

confidence: 99%

Stress, optimism, and social support: Impact on immune responses in breast cancer

Kang

Carpenter

2007

Research in Nursing & Health

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The purpose of this study was to examine the direct and stressbuffering effect of optimism and satisfaction with social support on immune responses in women with breast cancer. Participants were 54 post-operative (M ¼ 19 days) breast cancer patients who completed questionnaires on stress, optimism, and satisfaction with social support and provided blood to measure natural killer cell activity (NKCA) and interferon-gamma (IFN-g) from whole blood. Higher levels of stress were associated with decrements in NKCA and IFN-g. Optimism moderated the relationship of stress on NKCA but was not related to IFN-g. Satisfaction with social support was unrelated to immune responses. Results suggest that interventions aimed at reducing stress and enhancing optimism in women with breast cancer might promote optimal immune response. ß

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Section: Instrumentsmentioning

confidence: 99%

Stress, optimism, and social support: Impact on immune responses in breast cancer

Kang

Carpenter

2007

Research in Nursing & Health

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“…Surgical trauma is often accompanied by a diminished immunocompétence [2,4,8,9,11,16,17,19,20], characteristics of which are lymphopenia and a decreased responsive ness of blood T lymphocytes to polyclonal mitogens [2,9,19]. Skin reaction to recall mitogens may also become attenuated [9], Suppressor cells seem to be partly involved in causing these phenomena (1,6,13,15,23,24].…”

Section: Introductionmentioning

confidence: 99%

Influence of Operative Trauma on Circulating Blood Mononuclear Cells: Analysis Using Monoclonal Antibodies

Grzelak¹,

Olszewski²,

Engeset³

1984

Eur Surg Res

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The influence of operative trauma on the quantity and proportion of cooperating mononuclear cells in peripheral blood of patients with stage 0 uterine cancer who underwent hysterectomy was studied using monoclonal antibodies. The percentage of OKM1⁺ cells (monocytes) had increased on day 1 by 12.4%, on day 3 by 24.8%, and had returned to normal by day 7. The percentage of large OKIa1⁺ cells (expressing la antigen) on day 1 was increased by 186.9%, while on day 3 it had returned to a normal level. There was a decrease on day 1 of the number and percentage of OKT3⁺ cells (all T lymphocytes) by 17.4%, OKT4+ cells (helper/inducer cells) by 27.9%, OKT8+ cells (suppressor/cytotoxic cells) by 24.6%, and small OKIa1⁺ cells by 49.4%. The number and percentage of T lymphocytes remained below the preoperative level throughout the observation period. However, the number of helper cells had increased significantly on day 5, while suppressor cells remained below the preoperative level during the entire observation period. The rising ratio of OKT4⁺/OKT8⁺ cells reflected the kinetics of recovery of the helper over the suppressor cell population.

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“…It has been shown that after an operation there is a reduction of T-cell function as measured by leucocyte migration (Cochran et al, 1972), leucocyte cytotoxicity (Vose and Moudgil, 1975) and phytohaemagglutinin-induced lymphocyte transformation (Riddle, 1967). Operative stress is also associated with impairment of B-cell function, as measured by pokeweed mitogen and streptolysin stimulation (Jubert et al, 1973) and macrophage inhibition, measured as the reduced uptake of 131I-labelled lipid emulsion and 51Cr-labelled Walker 256 tumour cells by hepatic Kupifer cells (Saba and Antikatzides, 1976). The depression of macrophages may be due to the consumption of a glycoprotein, at the site of trauma, which is opsonic for Kupffer-cell phagocytic activity (Saba and Scovill, 1975).…”

Section: Discussionmentioning

confidence: 99%

Effects of amputation and Corynebacterium parvum on tumour metastases in mice

Mosley¹,

Sadler²,

Castro³

1978

Br J Cancer

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Summary. The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated.Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth.Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.

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Effects of surgery, anesthesia and intraoperative blood loss on immunocompetence

Cited by 125 publications

References 12 publications

Stress, optimism, and social support: Impact on immune responses in breast cancer

Stress, optimism, and social support: Impact on immune responses in breast cancer

Influence of Operative Trauma on Circulating Blood Mononuclear Cells: Analysis Using Monoclonal Antibodies

Effects of amputation and Corynebacterium parvum on tumour metastases in mice

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