Stress, optimism, and social support: Impact on immune responses in breast cancer

Ah, Diane Von; Kang, Duck Hee; Carpenter, Janet S.

doi:10.1002/nur.20164

Cited by 50 publications

(20 citation statements)

References 61 publications

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“…Depression has also been associated with a poorer cellular immune response to specific antigens in breast cancer patients (35). It should be noted, however, that not all findings have been consistent in this literature (e.g., 36). …”

Section: Biobehavioral Factors and The Cellular Immune Response In Camentioning

confidence: 56%

Biobehavioral Factors and Cancer Progression

Lutgendorf

Sood²

2011

Psychosomatic Medicine

164

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Epidemiological evidence increasingly has supported the role of biobehavioral risk factors such as social adversity, depression, and stress in cancer progression. This review describes in vitro, in vivo, and clinical studies demonstrating relationships between such processes and pathways involved in cancer progression. These include effects on the cellular immune response, angiogenesis, invasion, anoikis, and inflammation. Biobehavioral factors have been shown to contribute to the cross-talk between tumor and host cells in the tumor microenvironment and stress effects on host cells such as macrophages appear to be critical for many pathways involved in tumor progression. Some effects are bi-directional, in that tumor derived inflammation appears to affect central nervous system processes, giving rise to vegetative symptoms and contributing to dysregulation of the HPA axis with downstream effects on inflammatory control. Findings to date are reviewed and fruitful areas for future research are discussed.

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Section: Biobehavioral Factors and The Cellular Immune Response In Camentioning

confidence: 56%

Biobehavioral Factors and Cancer Progression

Lutgendorf

Sood²

2011

Psychosomatic Medicine

164

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“…For example, in early-stage breast cancer patients, poor social support following surgery was associated with impaired NKCC concurrently (Levy, Herberman, Maluish, Schlien, & Lippman, 1985) and three months later (Levy, Herberman, Lippman, & D’Angelo, 1987). Although stress-related immune decrements have been seen in many laboratories, not all findings have been consistent in this literature (e.g., (Von Ah, Kang, & Carpenter, 2007), and they may be dependent on the type of stress assessment used (e.g., Mundy-Bosse, Thornton, Yang, Andersen, & Carson, 2011). …”

Section: Stress-related Effects On Host Cellsmentioning

confidence: 78%

Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions.

Lutgendorf

Andersen

2015

American Psychologist

146

115

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Over the last decade, there have been groundbreaking strides in our understanding of the multiple biological pathways by which psychosocial and behavioral factors can affect cancer progression. It is now clear that biobehavioral factors not only affect cellular immunity but both directly and indirectly modulate fundamental processes in cancer growth, including inflammation, angiogenesis, invasion, and metastasis. There is also an emerging understanding of how psychological and behavioral factors used in interventions can impact these physiological processes. This review outlines our current understanding of the physiological mechanisms by which psychological, social, and behavioral processes can affect cancer progression. The intervention literature is discussed, along with recommendations for future research to move the field of biobehavioral oncology forward.

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“…Despite the accumulating evidence the psychological state of cancer patients can alter cellular immunity, it should be noted that not all findings have been consistent [75], and effects on cellular immune markers have varied [64, 67, 76]. Moreover, the implications of these relationships for clinical endpoints including disease recurrence and survival have been difficult to investigate due to the large sample size and long follow-up required.…”

Section: Biobehavioral Pathways: Immunosuppressionmentioning

confidence: 99%

Biobehavioral Influences on Cancer Progression

Costanzo¹,

Sood²,

Lutgendorf³

2011

Immunology and Allergy Clinics of North America

103

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SynopsisThis review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. We describe behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiological pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell-signaling pathways. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Finally, behavioral and pharmacological interventions for cancer patients with the potential to alter these biobehavioral pathways are discussed.

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Stress, optimism, and social support: Impact on immune responses in breast cancer

Cited by 50 publications

References 61 publications

Biobehavioral Factors and Cancer Progression

Biobehavioral Factors and Cancer Progression

Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions.

Biobehavioral Influences on Cancer Progression

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