Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats

Mao, Qing-Qiu; Huang, Zhen; Zhang, Xiaoming; Feng, Chun-Rong; Pan, Ai-Juan; Li, Zhao-Yi; Ip, Siu‐Po; Che, Chun‐Tao

doi:10.1016/j.jep.2010.01.050

Cited by 34 publications

(33 citation statements)

References 37 publications

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“…Within whole hippocampus, CMS consistently reduces BDNF mRNA expression (Nibuya et al, 1999; Song et al, 2006; Mao et al, 2009a, 2010a,b; Hu et al, 2010a,b). However, the reliability of this effect is lost when subregions of the hippocampus are analyzed.…”

Section: Neurochemical Systemsmentioning

confidence: 96%

Neurobiology of chronic mild stress: Parallels to major depression

Hill

Hellemans

Verma

et al. 2012

Neuroscience & Biobehavioral Reviews

369

223

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The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an animal model of depression more than 20 years ago. The foundation of this model was that following long-term exposure to a series of mild, but unpredictable stressors, animals would develop a state of impaired reward salience that was akin to the anhedonia observed in major depressive disorder. In the time since its inception, this model has also been used for a variety of studies examining neurobiological variables that are associated with depression, despite the fact that this model has never been critically examined to validate that the neurobiological changes induced by CMS are parallel to those documented in depressive disorder. The aim of the current review is to summarize the current state of knowledge regarding the effects of chronic mild stress on neurobiological variables, such as neurochemistry, neurochemical receptor expression and functionality, neurotrophin expression and cellular plasticity. These findings are then compared to those of clinical research examining common variables in populations with depressive disorders to determine if the changes observed following chronic mild stress are in fact consistent with those observed in major depression. We conclude that the chronic mild stress paradigm: (1) evokes an array of neurobiological changes that mirror those seen in depressive disorders and (2) may be a suitable tool to investigate novel systems that could be disturbed in depression, and thus aid in the development of novel targets for the treatment of depression.

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Section: Neurochemical Systemsmentioning

confidence: 96%

Neurobiology of chronic mild stress: Parallels to major depression

Hill

Hellemans

Verma

et al. 2012

Neuroscience & Biobehavioral Reviews

369

223

View full text Add to dashboard Cite

show abstract

“…Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions traditional Chinese medicine (TCM) and many TCM compounds are receiving more attention for their extensive applications in China (Luo et al, 2000;Li et al, 2003;Peng et al, 2007;An et al, 2008a,b;Zhang et al, 2009;Kwon et al, 2010;Mao et al, 2010;Zhou et al, 2010).…”

Section: Research Articlementioning

confidence: 99%

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

Aimin¹,

Ma²,

Zhang³

et al. 2012

Pharmaceutical Biology

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“…The herbal preparation was also effective in improving chronic stress-induced behavioral alterations in mice (Zhong et al, 2006b). Furthermore, recent studies in our laboratory showed that SYJN (1300 and 2600 mg/kg, intragastrically) could reverse the behavioral alterations and decreased BDNF expression in rats exposed to chronic unpredictable stress, suggesting that SYJN may exert significant antidepressant-like effect in chronic unpredictable stress-treated rats through upregulation of BDNF expression (Mao et al, 2010). However, until now, we know nothing about the effects of SYJN on NT-3 and NGF expression in chronic unpredictable stress (CUS)-induced depression model.…”

Section: Introductionmentioning

confidence: 92%

“…080321) had been kept. The herbal materials were extracted as previously described (Huang et al, 2009;Mao et al, 2010). Briefly, the mixture of SYJN was left to macerate in distilled water (1:8, w/v) for 30 min at room temperature with occasional stirring, and then boiled for 60 min.…”

Section: Preparation Of Syjnmentioning

confidence: 99%