Herbal formula SYJN increases neurotrophin-3 and nerve growth factor expression in brain regions of rats exposed to chronic unpredictable stress

A study of the functional significance of epidermal growth factor in major depressive disorder

“…For example, the levels of brain-derived neurotrophic factor (BDNF) were reduced in both the postmortem brain and circulation in patients with MDD (Dwivedi et al, 2003;Karege et al, 2005;Brunoni et al, 2008;Sen et al, 2008). It has also been found that BDNF, nerve growth factor (NGF), neurotrophin-3 (NT-3), and vascular endothelial growth factor (VEGF) are reduced in the rat models of MDD (Ueyama et al, 1997;Bergstrom et al, 2008;Mao et al, Supplemental digital content is available for this article. It has also been found that BDNF, nerve growth factor (NGF), neurotrophin-3 (NT-3), and vascular endothelial growth factor (VEGF) are reduced in the rat models of MDD (Ueyama et al, 1997;Bergstrom et al, 2008;Mao et al, Supplemental digital content is available for this article.…”

“…Microarray studies of the postmortem brains revealed that some family members of the fibroblast growth factor (FGF) were altered in patients with MDD (Evans et al, 2004). Treatments with either antidepressant drugs or electroconvulsive therapy could upregulate the levels of BDNF, FGF-2, NGF, and VEGF in MDD patients and animal models (Maragnoli et al, 2004;Warner-Schmidt and Duman, 2007;Sen et al, 2008;Mao et al, 2010), suggesting that neurotrophic factors may play an important role in the development of MDD. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.psychgenetics.com).…”

Chronic Stress Induces Neurotrophin-3 in Rat Submandibular Gland

“…Furthermore, alteration in NT-3 content in the central nervous system has been reported to play an important role in the pathogenesis of neural diseases related to chronic stress 28. Because blood NT-3 levels increase with the use of psychotropic agents,29 the NT-3 content in serum and plasma may have clinical significance in the evaluation of mental disorders.…”

A Review on Bioactivities of Perilla: Progress in Research on the Functions of Perilla as Medicine and Food

“…Perillae herba is included in Japanese Kampo medicines such as Hangekobokuto (Chinese name: Banxia Houpu; [3–6, 12–15]), Kososan (Chinese name: Xiang-Su-San; [8]), and Saibokuto (Chinese name: Chai-Pu-Tang) for the treatment of cough and stress symptoms [2]. Perillae herba is also found in Chinese Suyu-Jiaonang (SYJN), which is also used to treat mental conditions [9, 16]. …”