Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children

Abstract

Recent studies have suggested some beneficial effects of probiotics and/or prebiotics on obesity in adults; such experience is limited in children and adolescents. This study was an open-label, randomised, controlled study including children with primary obesity. The first group was treated with a standard method with a reduced calorie intake and increased physical activity. The second group received add-on daily synbiotic supplementation during one month. The aim of this study was to evaluate potential effects of a synbiotic on anthropometric measurements, lipid profile and oxidative stress parameters. One month of supplementation of the synbiotic resulted in a significant reduction of weight (P<0.001) and body mass index (P<0.01). Changes (% reduction comparing to baseline) in anthropometric measurements, were significantly higher in the children receiving the additional synbiotic supplement (P<0.05). The percentage of children with weight loss was higher in the synbiotic group, but not statistically significant (71.4 vs 64.2%, P>0.05). At the 30(th) day of synbiotic intervention, serum total cholesterol, low density lipoprotein cholesterol and total oxidative stress levels significantly declined (P<0.05). Changes in serum lipid levels were significantly higher in the synbiotic group (P<0.05). Changes in serum total oxidative stress levels before and after the intervention period, were significant in synbiotic group (P<0.01). In our study, changes in weight, body mass index, and triceps skinfold thickness were higher in the group receiving the one month synbiotic supplement thin in the standard method group. The supplement tested also had a beneficial effect on lipid profile and total oxidative stress. To the best of our knowledge, this is the first study showing the effects of synbiotics on oxidative stress in obese patients with an additional effect on weight loss regarding to previous studies.

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

“…Safavi et al (27) showed a significant difference in all lipid parameters after 8 weeks of synbiotic supplementation in obese children. In contrast, Ipar et al (28) found significant improvement only in TC and LDL levels and not in TG levels after synbiotic supplementation, as in our study. Effects of probiotics or synbiotics on TG levels have some controversies; Gao et al (26) revealed that lipid-lowering effect of probiotics or synbiotics may vary in different countries/ethnicities.…”

Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis

“…These 12 articles included a total of 767 samples, with 391 treatments and 376 controls. [25][26][27][28][29][30][31][32][33][34][35][36] The detailed results are shown in Table 1 and Table S1. † Five of these studies were conducted in Asia, [25][26][27]29,30 five were conducted in Europe, 28,[31][32][33]36 one in Oceania, 35 and one in America.…”

“…[25][26][27][28][29][30][31][32][33][34][35][36] The detailed results are shown in Table 1 and Table S1. † Five of these studies were conducted in Asia, [25][26][27]29,30 five were conducted in Europe, 28,[31][32][33]36 one in Oceania, 35 and one in America. 34 The subjects were adults in seven papers, [25][26][27][28][34][35][36] children or adolescents in three papers, [29][30][31] and women in two papers.…”

Adipositas, metabolische Komorbiditäten und Mikrobiommodulation in der Pädiatrie

“…Ein günstiger Effekt von mehreren Bakterienstämmen (Lactobacillen und Bifidobakterien) in Kombination mit Fructooligosacchariden auf den BMI-Z-Score und den Bauchumfang ("Synbiotikum") wurde außerdem in einer doppelblinden randomisierten [32] bzw. einer offen randomisierten Studie an Kindern mit Adipositas berichtet [15].…”