Effects of T3 and fluoxetine in the novelty-suppressed feeding test model of depression and anxiety: gender differences

Shalom, G.; Lifschytz, Tzuri; Lerer, Bernard; Newman, Makalya

doi:10.1016/s0924-977x(06)80058-1

Cited by 6 publications

(5 citation statements)

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“…As shown in our results, the differences in sucrose preference between control and CIS groups indicate the presence of obvious anhedonia and depression in the CIS rats. The NSF test was used to determine the animal’s mental and behavioral changes by observing the feeding latency of animals in a novelty environment 36. The results revealed that the feeding latency of rats in the CIS group was significantly longer than that in the control group, which verified the depressive-like changes in the CIS rats.…”

Section: Discussionmentioning

confidence: 86%

Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus

Hu¹,

Yan²,

et al. 2018

NDT

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BackgroundTryptophan metabolism has always been considered to play a vital role in mental disorder diseases, and how traditional Chinese formula Xiaoyaosan regulates the tryptophan metabolism is a complement to the pathogenesis of depression. This study established a depression rat model by the chronic immobilization stress (CIS) method and observed the change in tryptophan metabolism in hippocampus and the effects of Xiaoyaosan.MethodsForty-eight male Sprague Dawley (SD) rats were randomly divided into the following four groups: control group, CIS group, Xiaoyaosan group, and fluoxetine group. The depression model was established by the 21-day CIS. The food intake and body weight were recorded, and the sucrose preference test (SPT), novelty suppressed feeding (NSF) test and open field test (OFT) were also used to evaluate the model. Then, the contents of tryptophan and 5-hydroxytryptamine (5-HT) in hippocampus were detected by the ELISA method, and the expression levels of tryptophan hydrogenase 2 (TPH2) and indoleamine 2,3-dioxygenase 1 (IDO1) in hippocampus were determined by quantitative reverse transcriptase polymerase chain reaction reaction (qRT-PCR) and Western blot methods.ResultsThe behavioral data showed a significant difference between the model group and the normal group. The 5-HT content in the hippocampi of CIS rats was significantly reduced, whereas the tryptophan content in the hippocampi of model rats was significantly increased. The TPH2 level in hippocampus of the model group was significantly decreased, and the IDO1 level was significantly increased. Xiaoyaosan and fluoxetine could significantly reverse these changes and had obvious curative effects.ConclusionThe abnormal tryptophan metabolism existed in the hippocampi of chronic stress-depressed rats, which was closely related to the pathogenesis of depression. Xiaoyaosan could improve the tryptophan metabolism by regulating the expression levels of TPH2 and IDO1, thus exerting an antidepressant-like effect.

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Section: Discussionmentioning

confidence: 86%

Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus

Hu¹,

Yan²,

et al. 2018

NDT

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show abstract

“…So, it was widely used in the exploration of the pathogenesis of stress and the pharmacological study of potential antidepressants. The NSF test observed the contradiction between the fear of new environment and the great need for things, the food consumption and latency of feed could represent the degree of depression and anxiety in animals (Shalom et al, 2006). The results showed that there were obvious behavioral changes in the CUMS model group, including decreased sucrose preference rate, prolonged immobility time, longer latency of feed and decreased appetite.…”

Section: Discussionmentioning

confidence: 96%