Effects of Tadenan Pretreatment on Bladder Physiology and Biochemistry Following Partial Outlet Obstruction

Abstract

These results clearly demonstrate that Tadenan pretreatment protected the bladder from both the contractile and metabolic dysfunctions induced by partial outlet obstruction.

Beneficial effects of Tadenan therapy after two weeks of partial obstruction in the rabbit

“…However, we have extensive experience with this model, and based on the performance of hundreds of similar studies, in the mild model of obstruction there is always a marked decrease in compliance and a significant reduction in the contractile response to field stimulation at 2 weeks following obstruction [Kato et al, 1988[Kato et al, , 1990b. Similarly, in the severe model, at 2 weeks following obstruction there is always a marked reduction in the contractile responses to both field stimulation and bethanechol [Malkowicz et al, 1986;Levin et al, 1996b]. Following the initial 2-week period, there is either no further change or a progressive decrease in the contractile responses over the next several weeks.…”

Oral Kohki Tea and its protective effect against in vitro ischemic damage to the bladder

“…Pretreating rabbits with Pygeum africanum (Tadenan) for 3 weeks before the surgical creation of partial outlet obstruction prevented the development of the initial contractile and metabolic dysfunctions. Results of subsequent studies showed that treating rabbits previously subjected to partial outlet obstruction reversed decompensation and resulted in improved contractile function [Levin et al, 1996.…”

Effect of hydrogen peroxide on rabbit urinary bladder citrate synthase activity in the presence and absence of a grape suspension

“…Partial outlet obstruction and in vivo models of ischemia have marked deleterious effects on superoxide dismutase and catalase, and as stated above have also been demonstrated to produce significant oxidative damage (10,(12)(13)(14). A variety of antioxidants and natural products that show significant antioxidant properties have been shown to protect the rabbit urinary bladder from contractile, cellular, and subcellular damage and dysfunction mediated by both partial outlet obstruction, and bilateral ischemia / reperfusion (15)(16)(17)(18)(19)(20). One of the most potent of these agents has been shown to be a grape suspension made from whole grapes (13,21,22).…”