Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet

Abstract

Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups. One group was OVX and the other group received sham operation (SHAM), and received either control diet or a taurine supplemented diet for 6 weeks. All rats were fed on calcium deficient diet (AIN-93: 50% level of calcium) and deionized water. Bone mineral density (BMD) and bone mineral content (BMC) were measured in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined. Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations. Bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Urinary calcium and phosphorus excretion, osteocalcin in blood and cross link value were not significantly different among the groups. Within the OVX group, the taurine supplemented group had not higher femur bone mineral content than the control group. This study established the need for a study on the taurine effect on bone with different calcium levels.

Pretreatment Effect of Alcoholic Olive Leaf Extract on Oxidative and Antioxidative Enzymes Status in Ovariectomized Rats

“…The results showed that the mean body weight in ovariecto- mized rats compared with the control group significantly increased. These results agree with previous studies that weight gain is caused by lack of hormonal correspond (1,14). It is well known that weight gain occurs in postmenopausal women.…”

Proteomics Analysis to Identify and Characterize the Molecular Signatures of Hepatic Steatosis in Ovariectomized Rats as a Model of Postmenopausal Status

“…Body weight did not differ between Sham and Ovx groups (244 ± 2 g and 243 ± 5 g) at the beginning of study, but after four-month ovariectomy, body weight was higher for the Ovx group, by 1.26-fold, than the Sham group ( p = 0.0029) ( Figure 2 A). These results agree with earlier reports and it is believed that the increased body weight is due to hormonal deficiency in menopausal women and is linked to increased weight of particularly epididymal fat [ 27 , 28 , 29 ]. The mean liver weights in the Sham and Ovx groups did not differ (8.99 ± 0.27 g and 9.24 ± 0.71 g, respectively, p = 0.7468) ( Figure 2 B).…”

A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration

“…The positive effect of Tau on bone metabolism and regeneration are reported in other studies. Mi-Ja Choi 37 showed the beneficial effect of Tau supplementation on femur bone mineral content. In another study, Park et al 38 reported collagen synthesis, tyrosine phosphorylation, and alkaline phosphatase activity stimulation in UMR-106 cells under treatment with Tau.…”