Effects of tDCS on executive function in Parkinson's disease

Doruk, Deniz; Gray, Zachary; Bravo, Gabriela; Pascual‐Leone, Álvaro; Fregni, Felipe

doi:10.1016/j.neulet.2014.08.043

Cited by 162 publications

(155 citation statements)

References 32 publications

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“…We identified 15 studies that evaluated the effects of tDCS on patients with Alzheimer’s disease [111], [112], [113], [114], [115], [116], Parkinson’s Disease [109], [117], [118], [119], [120], [121], Dementia with Lewy Bodies [122], Corticobasal degeneration [123], and Frontotemporal dementia [124]. In all, there were over 275 patients (some assigned to sham conditions) who received between 7 and 30 minutes of stimulation in each of 1 to 10 sessions with an intensity of between 1 and 2.8 mA.…”

Section: Tdcs Special Considerations For Safety In Aging Populationsmentioning

confidence: 99%

“…Neither of these events appear to be attributable to tDCS and thus are not Serious Adverse Effects. Four studies reported typical side effects (i.e., itching, tingling, burning) [122], [116], [119], as well as temporary headache and dizziness [111]. It is also worthwhile to note that a review of eight tDCS studies in the geriatric depression literature found no major side effects of stimulation [125].…”

Section: Tdcs Special Considerations For Safety In Aging Populationsmentioning

confidence: 99%

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Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

et al. 2016

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This review updates and consolidates evidence on the safety of transcranial Direct Current Stimulation (tDCS). Safety is here operationally defined by, and limited to, the absence of evidence for a Serious Adverse Effect, the criteria for which are rigorously defined. This review adopts an evidence-based approach, based on an aggregation of experience from human trials, taking care not to confuse speculation on potential hazards or lack of data to refute such speculation with evidence for risk. Safety data from animal tests for tissue damage are reviewed with systematic consideration of translation to humans. Arbitrary safety considerations are avoided. Computational models are used to relate dose to brain exposure in humans and animals. We review relevant dose-response curves and dose metrics (e.g. current, duration, current density, charge, charge density) for meaningful safety standards. Special consideration is given to theoretically vulnerable populations including children and the elderly, subjects with mood disorders, epilepsy, stroke, implants, and home users. Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities (6.3–13 A/m2) that are over an order of magnitude above those produced by conventional tDCS. To date, the use of conventional tDCS protocols in human trials (≤40 min, ≤4 mA, ≤7.2 Coulombs) has not produced any reports of a Serious Adverse Effect or irreversible injury across over 33,200 sessions and 1,000 subjects with repeated sessions. This includes a wide variety of subjects, including persons from potentially vulnerable populations.

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Section: Tdcs Special Considerations For Safety In Aging Populationsmentioning

confidence: 99%

Section: Tdcs Special Considerations For Safety In Aging Populationsmentioning

confidence: 99%

Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

et al. 2016

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“…Doruk et al 28 performed a sham-controlled, doubleblinded study across two centers, assessing the immediate and long-term effects of ten consecutive sessions of tDCS over the anode on the right DLPFC (n=5), left DLPFC (n=6) or sham (n=7). Although the primary outcomes were cognition and mood, they evaluated the motor function.…”

Section: Tdcs For Upper Limb Motor Function In Pdmentioning

confidence: 99%

“…A further possibility is that a 1 mA stimulation would be insufficient to induce a significant release of dopamine, a possibility supported by studies in healthy subjects. 75 Doruk et al 28 conducted a multicenter, sham-controlled, double-blind study to assess the immediate and long-term effects of 10 consecutive sessions of tDCS. Anodal stimulation was delivered either over the right DLPFC (n=5), left DLPFC (n=6), or sham (n=7).…”

mentioning

confidence: 99%

Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS)

Tahtis¹,

Kaski²

2017

JPRLS

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“…In a small study of 18 adults with Parkinson’s disease, Doruk and colleagues found that placement of anodal current over either the left or right dorsolateral prefrontal cortex, compared to a sham control group, improved executive functioning over a 1-month period. 29 While such cognitive improvements have often been shown to result from tDCS, improvements in motor symptoms may be more limited.…”

Section: Therapeutic Usesmentioning

confidence: 99%

A description and critical analysis of the therapeutic uses of transcranial direct current stimulation: implications for clinical practice and research

Vance¹,

Fazeli²,

Cody³

et al. 2016

NRR

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For centuries, since the advent of harnessing magnetic and electrical energies, humans have been applying such energies to various body parts, including the brain, with the goal of improving health. Advancements over the past two decades in the production and affordability of such devices that precisely deliver such energies have resulted in novel therapeutic uses. One technique in particular, transcranial Direct Current Stimulation (tDCS), uses electrodes placed on the scalp to deliver a low electrical current to various areas on the surface of the neocortex. Such electrical currents stimulate neurons, which depending on the area of the neocortex it is applied and certain stimulation parameters, can either excite or inhibit certain functions within the brain that may result in alterations in mood, cognition, and behavior. This article provides an overview of this approach, explains how it is used, describes the hypothesized neurobiomechanisms involved, and explores its therapeutic potential. From this overview, implications for nursing practice and innovative uses for nursing research are posited.

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Effects of tDCS on executive function in Parkinson's disease

Cited by 162 publications

References 32 publications

Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS)

A description and critical analysis of the therapeutic uses of transcranial direct current stimulation: implications for clinical practice and research

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Effects of tDCS on executive function in Parkinson's disease

Cited by 162 publications

References 32 publications

Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016

Parkinson&#39;s disease treatments: focus on transcranial direct current stimulation (tDCS)

A description and critical analysis of the therapeutic uses of transcranial direct current stimulation: implications for clinical practice and research

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Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS)