Effects of tea polyphenols and EGCG on glucose metabolism and intestinal flora in diabetic mice fed a cornstarch-based functional diet

Liu, Jun; Lv, Yangjun; Pan, Junxian; Jiang, Yulan; Zhu, Yuejin; Zhang, Shikang

doi:10.1590/fst.50821

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…The relative abundance of Prevotellaceae in RS group and H-RR group was 13.96-14.74, while that in the other three groups was only 1.50-3.92. The abundance of Prevotellaceae in normal rats' intestinal flora was significantly higher than that of non-normal rats (Liu et al, 2022), indicating that recombinant rice could effectively restore rats' disordered intestinal flora.…”

Section: The Difference Of Intestinal Flora Distribution At the Level...mentioning

confidence: 90%

Metagenomics exploring the effect of recombinant rice based on lotus seed starch-broken rice flour on intestinal flora in rats

ZHANG

Dou

et al. 2022

Food Sci. Technol

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High fat diet may cause obesity, diabetes, atherosclerosis, hypertension, hyperlipidemia and other diseases, and even mortality. The recombinant rice based on mixing lotus seed starch and broken rice flour was used to feed high-fat diet rats, and its effects on body weight and organ index were determined. The changes of intestinal flora in rats were studied by macrogenomic technology, and the effects of lotus seed starch-broken rice flour recombinant rice (LSBR) on intestinal flora in rats were discussed. The results showed that adding enough LSBR could effectively inhibit the weight gain of rats, reduce the liver index from 0.3498 to 0.2836, and the kidney index from 0.0079 to 0.0072. The reduction of intestinal flora abundance and diversity caused by high-fat diet were improved, the relative abundance ratio of Firmicutes/Bacteroidete was reduced from 11.04 to 2.17, while the relative abundance of beneficial bacteria was increased.

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Section: The Difference Of Intestinal Flora Distribution At the Level...mentioning

confidence: 90%

Metagenomics exploring the effect of recombinant rice based on lotus seed starch-broken rice flour on intestinal flora in rats

ZHANG

Dou

et al. 2022

Food Sci. Technol

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“…In turn, Han et al [ 169 ] demonstrated that yellow tea, the least popular variety worldwide, has the strongest anti-hyperglycemic effects. Diabetic mice receiving a functional diet composed of corn-starch supplemented with tea polyphenols and EGCG showed a decreased fasting level of blood glucose as compared to mice not receiving polyphenols or EGCG; they also showed an improvement in terms of the intestinal microbiota profile [ 170 ]. Similar results were observed in diabetic rats receiving green tea enriched with catechin and inulin [ 171 ].…”

Section: Anti-obesogenic Antidiabetic and Antioxidative Properties Of...mentioning

confidence: 99%

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

Olcha

Winiarska-Mieczan

Kwiecień

et al. 2022

IJMS

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Endometrial cancer (EC) is second only to cervical carcinoma among the most commonly diagnosed malignant tumours of the female reproductive system. The available literature provides evidence for the involvement of 32 genes in the hereditary incidence of EC. The physiological markers of EC and coexisting diet-dependent maladies include antioxidative system disorders but also progressing inflammation; hence, the main forms of prophylaxis and pharmacotherapy ought to include a diet rich in substances aiding the organism’s response to this type of disorder, with a particular focus on ones suitable for lifelong consumption. Tea polyphenols satisfy those requirements due to their proven antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties. Practitioners ought to consider promoting tea consumption among individuals genetically predisposed for EC, particularly given its low cost, accessibility, confirmed health benefits, and above all, suitability for long-term consumption regardless of the patient’s age. The aim of this paper is to analyse the potential usability of tea as an element of prophylaxis and pharmacotherapy support in EC patients. The analysis is based on information available from worldwide literature published in the last 15 years.

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“…Functional ingredients in tea has many function actions, including reducing resistance to insulin (Lin and Lin, 2008) inhibiting lipid absorption (Nakai et al, 2005), and enhancing fat oxidation (Sae-tan et al, 2011) . Most importantly, studies have shown that tea could positively modify the intestinal flora (Thomas et al, 2010), and it play a role in protecting against diabetes (Ribaldo et al, 2009) by reversing and promoting the ecological balance of intestinal flora (Zhang et al, 2020;Liu et al, 2022). Matcha is one kind of tea resources, and is loved by young consumers because of its application in food.…”

Section: An Exploratory To Analysis the Effects Of The Dirrerent Role...mentioning

confidence: 99%

An exploratory to analysis the effects of the dirrerent roles of mathca on lipid metabolism and intestinal flora regulation between normal and diabetic mice fed a high-fat diet

Liu¹,

Li²,

Tan³

2022

Food Sci. Technol

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Fast food is becoming increasing popular as a social phenomenon, and it usually contains high fat contents. Matcha is one versatile tea, and its application in food brings lots of new consumers. Herein, a high-fat diet containing matcha was prepared, and in this study we investigated the effects of such a diet on lipid metabolism and intestinal flora of normal and diabetic mice. Results showed that diabetes had significant weight loss, hyperphagia, hyperlipidemia and intestinal flora disturbance, with particularly significantly increased Alistipes, Prevotella, Helicobacter, Acetatifactor and Bacteroides, and decreased Alloprevotella, Lactobacillus, Allobaculum and Akkermansia. In diabetes, matcha decreased serum triglyceride and LDL-C, increased HDL-C, reversed those bacteria trends besides Alistipes, Prevotella and Akkermansia. In normal mice, matcha decreased serum LDL-C, increased Parabacteroides, Bacteroidales_unclassified, Erysipelotrichaceae_unclassified and Barnesiella, Lachnospiraceae_unclassified, and decreased Helicobacter and Clostridium XlVa. Most importantly, matcha increased Porphyromonadaceae_unclassified, Lactobacillus, Alloprevotella, Prevotella and Allobaculum; and decreased Bacteroides and Enterobacteriaceae_unclassified in diabetes, however these changed bacteria in normal mice showed an opposite trend from diabetes. Intestinal flora balance is vital important to host, matcha helps to improve the balance of lipid metabolism and intestinal flora according to different character of host, and is a valuable addition to develop functional food.

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Effects of tea polyphenols and EGCG on glucose metabolism and intestinal flora in diabetic mice fed a cornstarch-based functional diet

Abstract: One-month-old Female Kunming mice (body weight 20±3 g) was provided by the Animal Experiment Center, Zhejiang Academy of Medical Sciences (Hangzhou, China). Basal feed was purchased from Jiangsu Collaborative Bioengineering co.

Cited by 8 publications

References 45 publications

Metagenomics exploring the effect of recombinant rice based on lotus seed starch-broken rice flour on intestinal flora in rats

Metagenomics exploring the effect of recombinant rice based on lotus seed starch-broken rice flour on intestinal flora in rats

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

An exploratory to analysis the effects of the dirrerent roles of mathca on lipid metabolism and intestinal flora regulation between normal and diabetic mice fed a high-fat diet

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