Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep

Shi, Ruijun; Li, Shuwei; Liu, Penggang; Guo, Lili; Gong, Shujuan; Wan, Yu

doi:10.1007/s11250-022-03216-5

Cited by 2 publications

(3 citation statements)

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“…The skin's response to DHT is mainly androgen receptors (ARs) [29][30][31]. With the increase of cellular levels of DH pression also significantly increases [31]. The experimental results validate tion, as shown in Figure 5D.…”

Section: Nmn Downregulation Ar Expression and Activation Wnt/β-cateni...supporting

confidence: 65%

“…Primary HDPCs were used as an in vivo model for relevant AGA conditions. The skin’s response to DHT is mainly influenced by androgen receptors (ARs) [ 29 , 30 , 31 ]. With the increase of cellular levels of DHT, the AR expression also significantly increases [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…The skin’s response to DHT is mainly influenced by androgen receptors (ARs) [ 29 , 30 , 31 ]. With the increase of cellular levels of DHT, the AR expression also significantly increases [ 31 ]. The experimental results validate this correlation, as shown in Figure 5 D. The control groups exhibited a significant upregulation in AR gene expression, demonstrating the effectiveness of the stimulation conditions in our tests.…”

Section: Resultsmentioning

confidence: 99%

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β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Xu,

Dai,

et al. 2024

Molecules

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β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer’s disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were observed after hair removal. The results indicated that NMN can reverse the state of hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), compared to that of minoxidil. In addition, the action mechanisms of NMN promoting hair growth in cultured human dermal papilla cells (HDPCs) treated with DHT were investigated in detail. The incubation of HDPCs with DHT led to a decrease in cell viability and the release of inflammatory mediators, including interleukin-6 (IL-6), interleukin-1Beta (IL-1β) and tumor necrosis factor Alpha (TNF-α). It was found that NMN can significantly lower the release of inflammatory factors induced by DHT in HDPCs. HDPCs cells are protected from oxidative stress damage by NMN, which inhibits the NF-κB p65 inflammatory signaling pathway. Moreover, the levels of androgen receptor (AR), dickkopf-1 (DKK-1), and β-catenin in the HDPCs were assessed using PCR, indicating that NMN can significantly enhance the expression of VEGF, reduced IL-6 levels and suppress the expression of AR and DKK-1, and notably increase β-catenin expression in DHT-induced HDPCs.

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Section: Nmn Downregulation Ar Expression and Activation Wnt/β-cateni...supporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Xu,

Dai,

et al. 2024

Molecules

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Analysis of differential expression of hair follicle tissue transcriptome in Hetian sheep undergoing different periodic changes

Chen,

Sun,

Sulaiman

2024

PeerJ

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Background This study provides new information on long non-coding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in the hair follicles of Hetian sheep via the sequencing and analysis of the transcriptome of skin hair follicles during three periods of periodicity change. This is important for improving the quality of carpet wool, providing a preliminary basis for further research on the targeting relationship of these mRNAs and their target genes, and providing a scientific basis for marker-assisted selection of Hetian sheep. Methods The periodic variation of anagen (P I, May, n = 3), catagen (p II, October, n = 3), and telogen (p III, January, n = 3) of the skin hair follicle tissue of three Hetian sheep ewes were selected. Skin samples were collected from the right mid-side of each sampled sheep at three hair follicle developmental stages. The three sheep were used for each developmental stage as biological and technical replicates for transcriptome sequencing and analysis. Results The statistical power of this experimental design, calculated in RNASeqPower, was 0.92. Differential expression analysis revealed 81 lncRNAs that were differentially expressed (46 up-regulated and 35 down-regulated) and 129 mRNAs that were differentially expressed (46 up-regulated and 83 down-regulated) during the PI and PII periods. Between the PI and PIII periods, a total of 144 differentially expressed lncRNAs and 693 differentially expressed mRNAs were identified. Of these, 73 lncRNAs were significantly up-regulated and 71 were significantly down-regulated, while 474 mRNAs were significantly up-regulated and 219 were down-regulated. Additionally, a total of 87 lncRNAs were found to be differentially expressed, with 40 up-regulated and 47 down-regulated, along with 39 differentially expressed mRNAs (23 up-regulated and 16 down-regulated), between the PII and PIII stages. The functional assessment revealed that the mRNA expressed in the cells is related to the membrane, cell processes, metabolism, extracellular region, and other GO items. It is enriched in thyroid hormone synthesis, choline metabolism, cancer, AMPK, Hedgehog, and other signaling pathways. Conclusion A total of 2,286 lncRNAs (including 965 known and 1,321 novel lncRNAs) and 20,879 mRNAs were identified. These co-expressed differentially expressed genes could be used as candidate genes for studying the periodic changes of the hair follicles in Hetian sheep.

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Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep

Cited by 2 publications

References 46 publications

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Analysis of differential expression of hair follicle tissue transcriptome in Hetian sheep undergoing different periodic changes

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