Effects of Tetraethylammoniumchloride (TEA), Vanadate, and Alkali Ions on the Lateral Leaflet Movement Rhythm of Desmodium motorium (Houtt.) Merr

Weber, Ulrike; Engelmann, Wolfgang; Mayer, W.-E.

doi:10.3109/07420529209064537

Cited by 12 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These effects are often noted following chronic, but not acute, exposure and occur within the range of concentrations used in humans for the treatment of bipolar disorder (0.6–1.2 mM). Most consistently, lithium has been shown to lengthen the circadian period across species, including single cells, plants, invertebrates, and vertebrates (including primates) [Hofmann et al, 1978; Kavaliers, 1981; Welsh and Moore‐Ede, 1990; Klemfuss, 1992; Weber et al, 1992; Klemfuss and Kripke, 1995; Abe et al, 2000]. Although data from human studies are insufficient and confounded by limitations of clinical studies, there are reports suggesting a free‐running period lengthening effect in humans [Johnsson et al, 1979, 1980, 1983; Klemfuss, 1992].…”

Section: Cycling and Circadian Rhythmsmentioning

confidence: 99%

Endophenotypes in bipolar disorder†

2002

View full text Add to dashboard Cite

The search for genes in bipolar disorder has provided numerous genetic loci that have been linked to susceptibility to developing the disorder. However, because of the genetic heterogeneity inherent in bipolar disorder, additional strategies may need to be employed to fully dissect the genetic underpinnings. One such strategy involves reducing complex behaviors into their component parts (endophenotypes). Abnormal neurophysiological, biochemical, endocrinological, neuroanatomical, cognitive, and neuropsychological findings are characteristics that often accompany psychiatric illness. It is possible that some of these may eventually be useful in subdefining complex genetic disorders, allowing for improvements in diagnostic assessment, genetic linkage studies, and development of animal models. Findings in patients with bipolar disorder that may eventually be useful as endophenotypes include abnormal regulation of circadian rhythms (the sleep/wake cycle, hormonal rhythms, etc.), response to sleep deprivation, P300 event-related potentials, behavioral responses to psychostimulants and other medications, response to cholinergics, increase in white matter hyperintensities (WHIs), and biochemical observations in peripheral mononuclear cells. Targeting circadian rhythm abnormalities may be a particularly useful strategy because circadian cycles appear to be an inherent evolutionarily conserved function in all organisms and have been implicated in the pathophysiology of bipolar disorder. Furthermore, lithium has been shown to regulate circadian cycles in diverse species, including humans, possibly through inhibition of glycogen synthase kinase 3-beta (GSK-3beta), a known target of lithium.

show abstract

Section: Cycling and Circadian Rhythmsmentioning

confidence: 99%

Endophenotypes in bipolar disorder†

2002

View full text Add to dashboard Cite

show abstract

“…A period-lengthening effect of vanadate on the electric potential, as found by Weber et al, (1992) and by us, was not reported by Mitsuno and Sibaoka (1989), It is an interesting and important finding that vanadate lengthened the period before the rhythm damped out. This indicates that the H* pump controls a physiological parameter involved in determining the period length of the rhythm, and makes it likely that the H* pump is part of the oscillator driving the lateral leaflet movement of Desmodium gyrans.…”

Section: Effects Of Vanadate and N2 On Leaflet Movementsmentioning

confidence: 48%

“…Vanadate is a potent inhibitor of the H* pump in the plasmalemma of plant cells (Simonis 1979), Application of vanadate depolarized the membrane potential (Fig, 3B), and the leaflet movement came to a halt in the lower position (Fig, IB), An arrest of the oscillation of the extracellular electric potential in Desmodium motorium was shown also by Mitsutio and Sibaoka (1989), They found 1 mA/ vanadate sufficient to arrest the oscillation within several minutes, Vanadate concentrations used by Weber et al (1992) to affect the leaflet move-ment rhythm were between 0,5 and 10 mM, However, it took 4 to 6 h at the higher, and 9 to 21 h at the lower concentrations to abolish the rhythm, ln our experiments 5 mM vanadate suppressed the rhythm within half an hour during electrophysiological experiments, when the terminal leaflet was present (Fig, 3), When the terminal leaflet was cut off and 20 mAf vanadate appiied, it took more than 2 h until the same reaction became visible (Fig. 1), Qualitatively, the results of Mitsuno and Sibaoka (1989), Weber et al,(192) and those presented here are the same, Tbe difference in the concentrations are probably due to the way of application (bathed pulvini or via transpiration stream), preparation of leaflets (with or without terminal leaflet), piant material (younger or older leaflets) and experimental conditions (temperature, light and air circulation),…”

Section: Effects Of Vanadate and N2 On Leaflet Movementsmentioning

confidence: 74%

Effects of vanadate, N₂ and light on the membrane potential of motor cells and the lateral leaflet movements of Desmodium motorium

Antkowiak¹,

Engelmann²,

Herbjornsen³

et al. 1992

Physiologia Plantarum

Self Cite

View full text Add to dashboard Cite

The lateral leaflets of Desmodium motorium (Houtt.) Merr. exhibit ultradian up‐ and down movements, which are paralleled by oscillations of the membrane potential of motor cells in the pulvinus. By different treatments we have tested the hypothesis that both that both oscillation‐types are causally related. The reactions of the leaflet movement and the membrane potential were evaluated by the following approaches. (1) Application of vanadate. an inhibitor of the proton pump in the plasmalemma. and N2 suppressed leaflet movements and finally arrested the leaflet in the lower position. Before the oscillations damped out, a strong lengthening in period was found. This indicates that the pump is part of the ultradian clock. A period lenthening and a final suppression of the rhythm by vanadate was also seen in the extracellular electric potential of the pulvinus. Intracellular recordings in situ showed that vanadate application depolarized the motor cells. (2) Light of high fluence rates diminished the amplitude of the oscillations of the membrane potential of single motor cells and shortened the period. The same effects were observed when monitoring the lateral leaflet movement. The leaflet always moved towards the direction of the light. whether it was applied from the abaxial or from the adaxial part of the pulvinus. (3) When light was applied to the pulvinus of lateral leaflets. which had spontancously stopped moving in an upper position. oscillations were induced transiently. This effect was also found for the membrane potential of motor cells in the pulvinus. ‐ Our results thus provide further evidence that the membrane potential controls the volume state of the motor cells in the pulvinus of lateral leaflets of Desmodium motorium.

show abstract

“…A more direct relation between OEP and movement generated in pulvini was demonstrated by means of ICI. Administration of TMB‐8, TEA and vanadate into pulvini of Desmodium motorium increased leaves oscillation period from 5 to 80% (Weber et al , Chen et al , Engelmann and Antkowiak ). There is little information on whether ICI also affects CN.…”

Section: Discussionmentioning

confidence: 99%

Electrical potential oscillations – movement relations in circumnutating sunflower stem and effect of ion channel and proton pump inhibitors on circumnutation

Kurenda

Stolarz

Zdunek

2014

Physiologia Plantarum

View full text Add to dashboard Cite

The physiological control and molecular mechanism of circumnutation (CN) has not yet been fully understood. To gain information on the CN mechanism, the relationship between the changes of electrical potential and movement in the circumnutating sunflower stem and effect of ion channels and proton pump inhibitors on CN parameters were evaluated. Long-term electrophysiological measurements and injection of solutions of ion channel inhibitors (ICI) into sunflower stem with the simultaneous time-lapse recording of the movement were made. The oscillations of electrical potential (OEP) - movement relations - consist of cells depolarization on the deflected side of the stem and, at this same time, cells hyperpolarization on the opposite side of the stem. The delay of organ movement in relation to electrical changes of approximately 28 min (22% of the period) may indicate that the ionic fluxes causing the OEP are the primary phenomenon. The biggest decrease of CN period was observed after injection of proton pump (approximately 26%) and cation channel (approximately 25%) inhibitors, while length and amplitude were reduced mainly by calcium channel inhibitors (approximately 67%). Existence of OEP only in circumnutating part of sunflower stem and reduction of CN parameters and OEP amplitude after application of ICI prove that the CN cellular mechanism is associated with transmembrane ion transport.

show abstract

Effects of Tetraethylammoniumchloride (TEA), Vanadate, and Alkali Ions on the Lateral Leaflet Movement Rhythm of Desmodium motorium (Houtt.) Merr

Cited by 12 publications

References 17 publications

Endophenotypes in bipolar disorder†

Endophenotypes in bipolar disorder†

Effects of vanadate, N₂ and light on the membrane potential of motor cells and the lateral leaflet movements of Desmodium motorium

Electrical potential oscillations – movement relations in circumnutating sunflower stem and effect of ion channel and proton pump inhibitors on circumnutation

Contact Info

Product

Resources

About

Effects of Tetraethylammoniumchloride (TEA), Vanadate, and Alkali Ions on the Lateral Leaflet Movement Rhythm of Desmodium motorium (Houtt.) Merr

Cited by 12 publications

References 17 publications

Endophenotypes in bipolar disorder†

Endophenotypes in bipolar disorder†

Effects of vanadate, N2 and light on the membrane potential of motor cells and the lateral leaflet movements of Desmodium motorium

Electrical potential oscillations – movement relations in circumnutating sunflower stem and effect of ion channel and proton pump inhibitors on circumnutation

Contact Info

Product

Resources

About

Effects of vanadate, N₂ and light on the membrane potential of motor cells and the lateral leaflet movements of Desmodium motorium