Effects of the angiotensinogen gene M235T and A(-6)G variants on blood pressure and other vascular risk factors in a Spanish population

Abstract

Angiotensinogen (AGT) gene polymorphism has shown significant differences in the allelic frequencies between hypertensive and normotensive subjects. This allele frequency varies among ethnic groups. There are still some controversies related to the 235T-variant as a marker for essential hypertension. As part of an extensive case-control study carried out in a Spanish population, we selected the 237 subjects with a diagnosis of essential hypertension according to the established criteria. A group of 242 normotensives matched for age and gender was used as control. Smoking habits, a previous diabetes and hypertension medical history, body mass index (BMI) and blood pressure (BP) values were recorded. Glucose, plasma creatinine, lipid profile with Lp(a), homocysteine and microalbuminuria were measured. Angiotensinogen M235T-gene polymorphism was

An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

“…Rodriguez-Perez et al 23 refer similar results to ours in allelic and/or genotype differences in two angiotensinogen polymorphisms between normotensives and hypertensives (even with similar numbers of study participants) but with no association with BMI and smoking. Cooper et al 24 did not found a similar association of ATG genotype (M235T) in obese hypertensive population when obesity is defined as BMI above 31 kg/m 2 .…”

Angiotensinogen Single Nucleotide Polymorphisms, Elevated Blood Pressure, and Risk of Cardiovascular Disease

“…Failure of previous genderstratified studies [13][14][15] to show an association may be due to small sample size and/or lack of stratification by gender. A(Ϫ20)C has previously been shown to modify an estrogenresponsive element located in the regulatory region of the show mean values for all women and men, respectively, in the general population.…”

“…5 SNPs in the transcription factor binding region (Ϫ25 to Ϫ1) of the angiotensinogen gene promoter have been reported to affect gene expression. 6 -8 The Ϫ6A SNP has been associated with increased gene transcription, 8,9 elevated blood pressure, and increased risk of IHD in some 10 -12 but not in all studies, [13][14][15] whereas the Ϫ20C SNP has been associated with increased gene transcription, elevated angiotensinogen levels, and elevated blood pressure in one 7 but not in other studies. 1,10,15 These conflicting results may be due to small sample size in previous studies, which have included between 301 and 1232 participants.…”

Multilocus Analysis of Hypertension: A Hierarchical Approach

“…For example, studies of variants in the angiotensinogen gene, one of the genes with the most consistent findings, still have a large number of both positive [7][8][9][10] and negative results [11][12][13][14]. This may be because the effects of the variants under study are small to undetectable in many genetic backgrounds/populations because they are effectively masked by effects of unstudied gene(s) that affect the phenotype [4,15].…”