Effects of the combination with α‐tricalcium phosphate and simvastatin on bone regeneration

Nyan, Myat; Sato, Daisuke; Kihara, Hidemichi; Machida, Tetsu; Ohya, Keiichi; Kasugai, Shohei

doi:10.1111/j.1600-0501.2008.01639.x

Cited by 97 publications

(105 citation statements)

References 43 publications

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“…5,9,10 Others, however, have found no beneficial effects. 9,19,20 The ideal doses and carriers have yet to be determined, and the issue remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…The speed at which the carrier releases the drug also plays a role in the local concentration and effectiveness of simvastatin. Stein et al 7 used 0.1 mg of simvastatin in methylcellulose gel and reported no stimulation of bone formation, whereas Nyan et al 10 used the same amount of simvastatin in combination with alpha-tricalcium phosphate and reported significant new bone formation, greater than that obtained using 0.25 and 0.5 mg of the drug.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 The results have often been encouraging. The purpose of the present study was to evaluate the influence of the association between simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Lima

Calixto

Anbinder³

2011

Braz. oral res.

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Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment with a combination of simvastatin solution (2.2 mg/50 µl) and DBBM (DBBMSIM-1); and treatment with simvastatin solution (0.5 mg/50 µl) and DBBM (DBBM-SIM-2). Animals were sacrificed on postoperative day 30 or 60, after which the calvariae were X-rayed and prepared for histomorphometric evaluation. The data were submitted to statistical analysis (p < 0.05). Xrays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and DBBM group samples. Histomorphometric analysis revealed that, on postoperative day 30, both DBBM and DBBMSIM-1 had a negative impact on bone formation. On postoperative day 60, none of the combinations tested impaired bone repair. These results showed that the association between DBBM and simvastatin had a negative impact on bone repair.

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“…5,9,10 Others, however, have found no beneficial effects. 9,19,20 The ideal doses and carriers have yet to be determined, and the issue remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Lima

Calixto

Anbinder³

2011

Braz. oral res.

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“…• Promotes early consolidation of the graft [24][25][26][27] • Hastens the mineralization of the graft [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Nyan et al concluded that simvastatin combined with calcium sulfate caused substantial bone regeneration in rat calvarial defects; however, with a considerable soft tissue inflammation and scabbing of the skin overlying the calvaria. Thus, the local effects of simvastatin could be doseand carrier-dependent [26].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Chauhan¹,

Maria²,

Managutti³

2014

J. Maxillofac. Oral Surg.

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Introduction Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration. Materials and methods A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group). Conclusion The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.

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Simvastatin‐Loaded β‐TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice

Chou

Ito

Otsuka

et al. 2012

Adv Healthcare Materials

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Effects of the combination with α‐tricalcium phosphate and simvastatin on bone regeneration

Abstract: When combined with alpha-TCP particles, 0.1 mg simvastatin is the optimal dose for stimulation of the maximum bone regeneration in rat calvarial defects without inducing inflammation and it could be applied as an effective bone graft material.

Cited by 97 publications

References 43 publications

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Simvastatin‐Loaded β‐TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice

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