Effects of the combined Herba Epimedii and Fructus Ligustri Lucidi on bone turnover and TGF-β1/Smads pathway in GIOP rats

Yang, Yan; Nian, Honglei; Tang, Xian‐Liang; Wang, Xiujuan; Liu, Renhui

doi:10.1016/j.jep.2017.02.033

Cited by 38 publications

(26 citation statements)

References 44 publications

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“…Besides, discontinuation of BPs therapy reversed the reduction in bone formation and it was reported CTX levels of BRONJ patients increased 2 pg/mL per day after BPs discontinuation . Glucocorticoids initially induce activation of osteoclasts and this effect will turn into inhibition when exposed to long term and high level; 2 mg/kg of DX in the present study was lower than an osteoclast‐inhibition dose (3.8 mg/kg) and was close to the dose‐inducing osteoporosis (1 mg/kg) . So the relatively low level and short term of DX in the current study may exert its active effects on osteoclasts.…”

Section: Discussionsupporting

confidence: 46%

The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

Liu

Mattheos

et al. 2017

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 46%

The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

Liu

Mattheos

et al. 2017

J Oral Pathology Medicine

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“…Meanwhile, FLL has the ability of improving liver and kidney deficiencies and reducing lower back soreness. Thusly, FLL can be clinically used to treat osteoporosis in prescriptions containing other herbs, such as Herbal Epimedii [ 21 ], Fructus Psoraleae [ 22 ], Herba Ecliptae [ 23 ] and Puerariae radix [ 24 , 25 , 26 ].…”

Section: The Bone-protective Actions Of Fructus Ligustrimentioning

confidence: 99%

Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

et al. 2017

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Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL. The initial inquiry was conducted for the presence of the following keywords combinations in the abstracts: Fructus Ligustri Lucidi, osteoporosis, phytochemistry, pharmacokinetics, pharmacology, osteoblasts, osteoclasts, salidroside. About 150 research papers and reviews were consulted. Results: FLL is assumed to exhibit anti-osteoporotic effects by improving liver and kidney deficiencies and reducing lower back soreness in Traditional Chinese Medicine (TCM). The data from animal and cell experiments demonstrate that FLL is able to improve bone metabolism and bone quality in ovariectomized, growing, aged and diabetic rats through the regulation of PTH/FGF-23/1,25-(OH)2D3/CaSR, Nox4/ROS/NF-κB, and OPG/RANKL/cathepsin K signaling pathways. More than 100 individual compounds have been isolated from this plant. Oleanolic acid, ursolic acid, salidroside, and nuzhenide have been reported to exhibit the anti-osteoporosis effect. The pharmacokinetics data reveals that salidroside is one of the active constituents, and that tyrosol is hard to detect under physiological conditions. Acute and subacute toxicity studies show that FLL is well tolerated and presents no safety concerns. Conclusions: FLL provides a new option for the prevention and treatment of osteoporosis, which attracts rising interests in identifying potential anti-osteoporotic compounds and fractions from this plant. Further scientific evidences are expected from well-designed clinical trials on its bone protective effects and safety.

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“…Professor Huiguang Xu, a famous doctor of TCM, has used the decoction of Herba Epimedii (HE) and Fructus Ligustri Lucidi (FLL) to treat kidney- yang deficiency syndrome of asthma, or to combine with GC for the treatment of asthma for almost 50 years [ 23 , 24 ]. HE and FLL, documented in Chinese ancient medicinal literatures, have strong actions of replenishing kidney- yang and kidney- yin , respectively [ 25 , 26 ]. In our previous researches, we established an asthma model in rats by repetitive ovalbumin (OVA)-challenge which replicated many of the features of the human disease asthma with a high degree of fidelity, and demonstrated that the decoction of HE and FLL in combination with administration of systemic GC (dexamethasone) had a better anti-inflammatory effect on the asthmatic model rats, and could prevent the inhibition of HPA axis and loss of bone mass, compared with the administration of dexamethasone [ 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide

Tang

Nian

et al. 2017

BMC Complement Altern Med

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BackgroundAsthma is characterized by chronic airway inflammation, leading to structura1 changes in the airway, collectively termed airway remodeling. Airway remodeling is thought to contribute to airway hyper responsiveness and irreversible airflow limitation. The combination of Herba Epimedii (HE) and Fructus Ligustri Lucidi (FLL) decoction and the systemic administration of glucocorticoids (GC) had a synergistic inhibitory action on airway inflammation in the asthmatic model rats. However, the effects of the combination on airway remodeling have not been studied and compared. In the present study, we investigated the effects of the co-administration of combined extracts of HE and FLL with inhaled GC (budesonide) on airway remodeling in the rat asthmatic model induced by ovalbumin (OVA).MethodsMale Sprague-Dawley rats were sensitized to intraperitoneal OVA followed by repetitive OVA challenge for 7 weeks. Treatments included extracts of HE and FLL (Extracts for short, 100 mg/kg by gastric perfusion), budesonide (1 mg budesonide suspension in 50 ml sterile physiological saline, 3 rats in an ultrasonic nebulizer by nebulized inhabation with a flow of 1.6 ml/min for 30 min), and co-administration of extracts of HE and FLL with budesonide (Co-administration for short) for 4 weeks. Lung histomorphometry and bronchoalveolar lavage fluid (BALF) cell count were assessed 24 h after the final OVA challenge. Levels of interleukin (IL)-4, IL-5 and IgE were measured by ELISA. Expressions of Collagen I and Collagen III were tested by immunohistology. Expressions of transforming growth factor (TGF) -β1, TGF-β2 and Smads mRNA were measured by quantitative real-time PCR.ResultsExtracts, budesonide and Co-administration significantly reduced allergen-induced increases in the serum levels of IL-4, IL-5 and IgE, the number of eosinophils in BALF, goblet cell hyperplasia, Collagen III integral optical density (IOD) and the mRNA expression of TGF-β2 and Smad2. Extracts and Co-administration could depress the IOD level of Collagen I and the positive area of Collagen I and Collagen III. Budesonide and Co-administration significantly alleviated the thickening of airway wall. Only Co-administration significantly decreased collagen deposition according to the morphometry of Masson’s-stained lung sections, the thickening of airway smooth muscle layer, the number of lymphocytes in BALF and the mRNA expression of TGF-β1 and Smad3, and this was associated with a significant increase in levels of Smad7 mRNA.ConclusionsThe findings suggested that the combination of budesonide and the herbal extracts had a better synergistic effect on airway remodeling in OVA-reduced asthma rats than the single use of budesonide.

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Effects of the combined Herba Epimedii and Fructus Ligustri Lucidi on bone turnover and TGF-β1/Smads pathway in GIOP rats

Cited by 38 publications

References 44 publications

The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide

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