Effects of the Ethanol Extract of the Stem Bark of Nauclea latifolia Smith [Rubiaceae] on Certain Biochemical and Haematological Indices of Swiss Albino Mice

Udobi, Chinweizu Ejikeme; Umoh, Betseabasi Edward

doi:10.9734/ajmah/2017/33284

Cited by 7 publications

(13 citation statements)

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“…Serum ALP level is a pointer of either liver function or bone metabolism due to its participation in the transport of metabolites across the cell membranes, protein synthesis, secretory activities, and glycogen metabolism [26][27][28]. The observed significant decrease in serum activity of ALP on all the days of administration of ethanolic bark extracts of N. latifolia and A. cordifolia at all doses compared to the control is in accordance with the researches of Udobi et al [29] and Olaleye et al [30]. The reduction could be due to inhibiting or inactivating ALP in situ, as observed by Oloyede et al [31] with Asa water and Akanji et al [32] with metabisulphate, revealing healthy liver function.…”

Section: Discussionsupporting

confidence: 86%

“…AST is responsible for the metabolism through transamination of aspartate and used as a sensitive indicator of liver disease [33,34]. The observed lowered serum AST activity of animals administered with ethanolic bark extracts of A. cordifolia is in agreement with the research of Udobi et al [29], Olaleye et al [30] and Akpanabiatu et al [34].…”

Section: Discussionsupporting

confidence: 80%

“…Derivatives of medicinal plant are used in folk medicine because they consist of molecules with pharmacological properties required for life sustainability for protecting or preventing illness and diseases thus, the safety of the plants are of great concern. Studies have revealed that ethanolic bark extracts of both N. latifolia and A. cordifolia consist of phytonutrients such as tannin, alkaloids, saponins, and flavonoids as antioxidants that are responsible for their medicinal use [19,29]. The plant extracts were able to offer some protection to the liver enzymes related to sub-cellular functions such as plasma membrane and the mitochondrion by reducing the serum activities of ALP, ALT and AST compared to the control.…”

Section: Discussionmentioning

confidence: 99%

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Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Ogunrinola

Fajana

Olaitan

et al. 2018

JRRS

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Introduction: The use of Nauclea latifolia and Alchornea cordifolia plants as herbal curative medicine is fast growing and the need to investigate the likely toxicity to avert severe medical issues. Aims: To assess the toxicity level, the liver function enzyme activities in rabbits (Oryctolagus cuniculus) administered with both ethanolic bark extracts of Nauclea latifolia and Alchornea cordifolia were studied. Materials and Methods: Eighty-four (84) rabbits were arbitrarily grouped into seven (n = 12), where group 1 is the control, and the remaining groups were orally administered with 500, 750 and 1000 mg/kg body weight of ethanolic bark extract of Nauclea latifolia and Alchornea cordifolia (LD50>1000mg/kg). In each group, after 24 hours of administration on the 1st, 3rd and 7th days, three animals were sacrificed. Markers of liver functions: serum alkaline phosphate (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes activities were monitored using spectrophotometry instrument. Results: The results show a significant (p < 0.05) reduction of ALP, AST and ALT activities at all doses for the days of administration of both ethanolic bark extracts of Nauclea latifolia and Alchornea cordifolia when compared to the control. Conclusion: The study suggests that ethanolic bark extracts of Nauclea latifolia and Alchornea cordifolia may possess relative hepatoprotective activity.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Ogunrinola

Fajana

Olaitan

et al. 2018

JRRS

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“…The LD 50 of NLS has already be estimated to be 850 mg/kg [34] in Wistar albino rats and 1414.2 mg/kg body weight in Swiss albino mice [35]. The dose levels 50, 100 and 200 mg/kg in this study was derived from 1/5, 1/10 and 1/20 th of LD 50 dose in rats.…”

Section: Acute Toxicity Studymentioning

confidence: 89%

“…The various hematological parameters analyzed include: PCV (packed cell volume), HGB (hemoglobin), WBC (total white blood cell), PLT (platelet), RBC (total red blood cell), MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration), NEU (neutrophils), LYM ( Lymphocytes), MEB (monocytes), MID (mid-range percent of monocytes, eosinophils, and basophils), MPV (mean platelet volume), RDW-SD (red cell distribution width-standard size), RDW-CV (red blood cell distribution width -coefficient of variation), RDW (red cell distribution width, platelet larger cell ratio (P-LCR). The analysis followed earlier reported procedure[35].…”

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confidence: 99%

Nauclea latifolia (Rubiaceae) Stem-bark Hydromethanolic Extract Abrogates a Histone Deacetylase Inhibitor - Induced Multifocal Toxicity in Albino Rats

Nwidu

Oboma

2019

EJMP

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Objective: Nauclea latifolia (Rubiaceae) stem-bark enjoys wide patronage in ethnomedicine due to multiplicity of usage. Acute and subacute hematological and biochemical toxicity studies are available in literature but none underpins its ameliorative effect with a histone deacetylase inhibitor (HDAC), valproic acid (VPA) which mediates multifocal toxicity in different histological milieu. Methods: Subacute exposure of experimental albino rats with a high dose of valproic acid (500 mg/kg) was executed orally one hour before post-treatment with Nauclea latifolia stem-bark (NLS) extract in three doses (50, 100, 200 mg/kg) and with another group of rats with reference drug, vinpocetine, 25 mg/kg daily for 28 consecutive days after which hematological and biochemical analyses were executed. The liver, kidney and lungs were abstracted for histopathological evaluation. Results: The HDAC inhibitor, Valproic acids induced multifocal biochemical insults on liver function enzymes, lipid profiles, electrolytes and kidney function which were dose- dependently and significantly (P < 0.05 – 0.001) abrogated by the varying doses of administered NLS extract. On the histology the NLS extract effects corroborated the biochemical study in the liver and kidney. The NLS did not demonstrate significant toxicological impingement on the hematology and did not alter VPA-induced histomorphological injury in the lungs cytoarchitecture. The reference drug, vinpocetine was unresponsive to VPA-induced alteration in all the tissues investigated in the administered posology. Conclusion: The NLS extract was effective in abrogating toxicological insults in the liver and kidney but not in the lungs. Further studies are required to understand the mechanism of pharmacological effects of NLS extract and the differential in tissue response.

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Biochemical Effects of Nauclea latifolia Ethanolic Root Extract in Rats

Udeh Sylvester,

Ogugua,

Ojochenemi

et al. 2023

Pharmacologia

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Background and Objective:The plant Nauclea latifolia (Smith) (Family: Rubiaceae) also known as 'Pin Cushion tree' or 'African Peach' is a struggling shrub, native to tropical Africa and Asia where the use of folk medicine is prevalent and the search for a herbal cure is but common practice. This report described the biochemical effects of Nauclea latifolia ethanolic root extract in rats. Materials and Methods:Extraction of the root of Nauclea latifolia with ethanol was carried out.A total of twenty Wister albino rats were used in this study. The rats were randomly divided into four groups of five rats each. The various biochemical tests were then conducted on the experimental rats. Results:The acute toxicity study on ethanol extract in mice established an intraperitoneal LD 50 greater than 4000 mg kgG 1 . The phytochemical analysis of the Nauclea latifolia ethanol extract indicated the presence of flavonoids, saponins and reducing sugars. The liver alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase and the serum concentrations of conjugated and total bilirubin measured suggest mild damage to the liver hepatocytes of rats treated with ethanolic extract of Nauclea latifolia root when compared to the control. The result of urea and creatinine indicate that the kidney may be damaged when compared to the control group. The extract caused a slight but nonsignificant increase (p>0.05) in blood glucose concentration as administration of the extract continued on days 28 and 42. Conclusion: The present study established that the continuous administration of the ethanol crude extract of Nauclea latifolia is lethal to the hepatocytes and kidneys.

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Effects of the Ethanol Extract of the Stem Bark of Nauclea latifolia Smith [Rubiaceae] on Certain Biochemical and Haematological Indices of Swiss Albino Mice

Cited by 7 publications

References 0 publications

Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Nauclea latifolia (Rubiaceae) Stem-bark Hydromethanolic Extract Abrogates a Histone Deacetylase Inhibitor - Induced Multifocal Toxicity in Albino Rats

Biochemical Effects of Nauclea latifolia Ethanolic Root Extract in Rats

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