Effects of the ether phospholipid AMG-PC on mast cells are similar to that of the ether lipid AMG but different from that of the analogue hexadecylphosphocholine

Grosman, Nina

doi:10.1016/0162-3109(91)90054-3

Cited by 10 publications

(3 citation statements)

References 30 publications

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“…In fact, AELs and APCs both appear to modulate PKC activity competitively with respect to phosphatidylserine.391,399,405,407,408 Interestingly, alkylmethylglycerols (AMGs), the putative cellular metabolites of AELs, interact competitively with the phorbol ester / diacylglycerol binding site to activate PKC. 399,409,410 However, this mechanism of activation is likely to be of minor significance, as the rate of metabolic conversion in cells is slow. 399 In addition to their effects on PKC, AELs and APCs are among the most potent known inhibitors of PI-PLC.262,391.418-420 However, lyso-PAF, which is less cytotoxic than the AELs, was found to be of similar potency to ET-18-OCH3,419 suggesting that inhibition of PI-PLC may not be the critical cellular lesion.…”

Section: Effects On Cell Signaling and The Involvement Of Specificmentioning

confidence: 99%

Phospholipid antitumor agents

Houlihan

Lohmeyer

Workman

et al. 1995

Medicinal Research Reviews

110

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Section: Effects On Cell Signaling and The Involvement Of Specificmentioning

confidence: 99%

Phospholipid antitumor agents

Houlihan

Lohmeyer

Workman

et al. 1995

Medicinal Research Reviews

110

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“…The first evidence that miltefosine could be used for chronic spontaneous urticaria was reported by Grosman, who described inhibition of histamine release from rat mast cells (144). Weller et al, in 2009, demonstrated that processes mediated by signal transduction receptors, such as those involved in immunoglobulin E (IgE) -receptor (FceRI) mast cell-dependent activation with subsequent degranulation, are regulated by lipid rafts in the cell membrane (145).…”

Section: Chronic Spontaneous Urticariamentioning

confidence: 99%

Alkylphospholipids – A Promising Class of Chemotherapeutic Agents with a Broad Pharmacological Spectrum

et al. 2013

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-PURPOSE:Since when alkylphospholipds (ALPs) were discovered and, even further after miltefosine's approval for the treatment of cutaneous metastasis of breast cancer and leishmaniasis, their activity against many other diseases have been extensively studied. This review aims to provide a summary of the alkylphospholipids' applications investigated so far. RESULTS: The mechanism of action of ALPs is not fully understood, however it is believed that they interfere with lipid homeostasis leading to cell apoptosis. Due to ALPs cytotoxic activity, this class of molecules has shown to be effective against many diseases and conditions. Besides the approval of miltefosine for application in cutaneous metastasis of breast cancer and visceral and cutaneous leishmaniasis, several other analogs have proved efficacy and are promising as less toxic alternatives. ALPs have also shown in vitro and in vivo activity against Trypanosoma spp., amoebae, Tricomonas vaginalis, Schistosoma mansoni, HIV, and some fungi and bacteria species. The use of ALPs for intraocular lens coating is also under investigation. In addition, a clinical trial comparing miltefosine with usual treatments to spontaneous urticaria is also being conducted. CONCLUSIONS: Alkylphospholipids present such a broad pharmacological spectrum that justifies the need for further investigations of the drug class mechanisms of action, as well as the search for new analogs with improved activity and toxicological profiles.

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“…Miltefosine is a derivative of cell membrane plasmalogen phospholipids, which are enriched in rafts containing FceRI (Surviladze et al, 2007), and there is a significant body of evidence demonstrating the inhibition of signal transduction pathways at the level of the cell membrane by miltefosine (Arthur and Bittman, 1998). Miltefosine has also been shown to be taken up by cells in a raftdependent fashion (van der Luit et al, 2007), suggesting that it has an affinity to lipid raft microdomains and Grosman (1991) reported the inhibition by miltefosine of histamine release from isolated rat MCs triggered with calcium ionophore A23187 and compound 48/80.…”

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confidence: 99%