Effects of the Hypnotic Agent on Primary Graft Dysfunction After Liver Transplantation

Martín, L. Gajate; González, Carmen; Torres, I. Ruiz; Martín, Carlos; Grande, A; Martin, Eloy; Roux, Daniel; Sánchez, Juan Macías

doi:10.1016/j.transproceed.2016.08.048

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…We found the following nomenclatures in the literature for EGD 7,17,18 : poor graft initial function 19,20 ; early allograft dysfunction, early graft failure 2,5,7,12,13 ; delayed non-function and impaired primary function 7 . There was a strong association between some genes and the oxidative stress and apoptosis in liver grafts, by favoring the proliferation of toxic metabolites.…”

Section: Resultsmentioning

confidence: 96%

“…Although the evaluation of an organ based on isolated laboratory data is controversial, a study showed an association of this parameter with graft failure, since the presence of donor comorbidities such as type II diabetes, chronic cardiovascular and renal disease, alcoholism or use of total parenteral nutrition alter the result of the exam 13,19 . Donor height =150cm 3 and serum sodium >160mEq/dl 19 The standardization of the anesthetic agent for the liver recipient has been investigated 2,18 .…”

Section: Resultsmentioning

confidence: 99%

“…Both propofol and sevoflurane are safe for use in liver transplant surgeries 18 . However, propofol has a higher risk for graft dysfunction compared with sevoflurane 2 .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Disfunção e não função primária do enxerto hepático: revisão integrativa.

Salviano

Lima

Tonelli

et al. 2019

Rev. Col. Bras. Cir.

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RESUMO Evitar mortes na fila de espera por um órgão não é mais o único foco de atenção das equipes de transplantação. As pesquisas e cuidados na prática clínica têm sido cada vez mais voltados para o funcionamento do enxerto pós-implante. O objetivo desse estudo foi identificar a nomenclatura utilizada na literatura para disfunção e não função de um enxerto hepático, bem como, investigar as incidências e fatores de risco. Trata-se de uma revisão integrativa da literatura de publicações na íntegra em português, inglês e espanhol, entre 2012 e 2016, nas bases: CINAHL, MEDLINE, Cochrane, LILACS, BDENF, IBECS, EMBASE e Web of Science. Foram selecionados 14 estudos em que se identificou incidências variando entre 7% e 27% e a nomenclatura utilizada para descrever o evento foi mau funcionamento inicial, hipofunção do enxerto, função marginal ou retardo na função. Foram encontradas incidências de não função primária do enxerto hepático entre 1,4% e 8,4% dos pacientes e a nomenclatura usada para descrever o evento foi disfunção precoce ou perda do enxerto. Os fatores de risco encontrados são relacionados às variáveis do doador, receptor, enxerto e logística do transplante. Conclui-se que o conhecimento das diferentes nomenclaturas empregadas na literatura, das incidências da disfunção e não função primária e seus fatores de risco são fundamentais para qualificar as intervenções de controle dos eventos na perspectiva de melhorar a sobrevida do paciente pós-transplante hepático.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Disfunção e não função primária do enxerto hepático: revisão integrativa.

Salviano

Lima

Tonelli

et al. 2019

Rev. Col. Bras. Cir.

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“…In our study, the degree of hypotension following reperfusion may not have been severe enough to induce clinical damage. In a previous study comparing sevoflurane and propofol use among patients undergoing DDLT [ 8 ], the authors observed no difference in early liver function between the groups. Together, these results suggest that there is no association between PRS and early postoperative outcomes.…”

Section: Discussionmentioning

confidence: 95%

“…Propofol inhibits sympathetic vasoconstrictor activity and chronotropy in a dose-dependent manner [ 21 , 22 ]. Sevoflurane inhibits sympathetic nervous activity but has little effect on parasympathetic nervous activity [ 23 ]; as such, its use has been associated with relatively low heart rate variability as well as cardioprotective effects [ 8 ]. During the anhepatic phase, the rate of propofol clearance decreases to approximately 42% [ 24 ], resulting in increased accumulation of propofol in the body, which in turn leads to an increase in the depth of anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study

Cho

Lee

et al. 2022

Anesth Pain Med

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Background: Post-reperfusion syndrome (PRS) results in sudden hemodynamic instability following graft reperfusion. Although PRS is known to influence outcomes following liver transplantation, little is known regarding the effects of anesthetics on PRS. This study investigated the association between the type of anesthetic agent and PRS in liver transplantation. Methods: This single-center retrospective cohort study included patients who underwent liver transplantation between June 2016 and December 2019. Patients were divided into sevoflurane and propofol groups according to the anesthetic agent used. Stabilized inverse probability of treatment weighting (IPTW) analysis was performed to investigate the association between PRS identified based on blood pressure recordings and the type of anesthesia. Associations between the anesthetic agent and the duration of hypotension as well as early postoperative outcomes were also investigated.Results: Data were analyzed for 398 patients, 304 (76.4%) and 94 (23.6%) of whom were anesthetized with propofol and sevoflurane, respectively. PRS developed in 40.7% of the 398 patients. Following stabilized IPTW analysis, the association with PRS was lower in the sevoflurane group than in the propofol group (odds ratio, 0.47; P = 0.018). However, there was no association between the type of anesthetic used and early postoperative outcomes. Conclusions: The association of PRS was lower in the sevoflurane group than in the propofol group. However, there was no association between the type of anesthetic and the early postoperative outcomes. Further studies are required to determine the optimal anesthetic for liver transplantation.

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Acute Kidney Injury in Hepatico-Pancreatic-Biliary Surgery and Liver Transplantation

Kim

2020

Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation

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Effects of the Hypnotic Agent on Primary Graft Dysfunction After Liver Transplantation

Cited by 9 publications

References 15 publications

Disfunção e não função primária do enxerto hepático: revisão integrativa.

Disfunção e não função primária do enxerto hepático: revisão integrativa.

Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study

Acute Kidney Injury in Hepatico-Pancreatic-Biliary Surgery and Liver Transplantation

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