Effects of the Inhalational Anesthetics Halothane and Sevoflurane on an Experimental Model of Hepatic Injury

Soubhia, Andrea Fogaça; Lauz, Susi; Montero, Edna Frasson de Souza; Menezes, Alessandro; Mespaque, Luciane Bicca; Facin, Emilio

doi:10.1016/s0034-7094(11)70070-8

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…8,9 Previous studies have shown that sevoflurane at clinical concentrations is not detrimental to liver and renal function. However, sevoflurane undergoes very little hepatic metabolism, and its metabolites are less reactive than those of other halogenated anaesthetics.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat

Zhou¹,

Jiang²,

Liu³

et al. 2013

European Journal of Anaesthesiology

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Section: Discussionmentioning

confidence: 99%

Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat

Zhou¹,

Jiang²,

Liu³

et al. 2013

European Journal of Anaesthesiology

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“…Thus, some authors affirm that the transaminases' values were slightly increased after inhaled anesthesia with sevoflurane (Soubhia et al, 2011). Some of them write that isoflurane and sevoflurane anesthesia induces an increase in the seric concentration of hepatic enzymes, isoflurane inducing a greater increase in comparison to sevoflurane (Nishiyama, 2013), while others write that the seric level of aspartate-aminotranferase (ASAT) slightly increased in the first day after sevoflurane anesthesia (Sun et al, 1997).…”

Section: Resultsmentioning

confidence: 99%

Presence and Distribution of the Vascularisation of Aortic Media in Some Mammals

Ruxanda¹,

Damian²,

Rus³

et al. 2015

BUASVMCN-VM

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The specialty literature contains uneven data regarding the effect of inhaled anesthetics on transaminases' values. Various studies show that the transaminases' values range from a small increase up to a massive increase post-anesthesia. In the present study, we utilized 40 rats, divided in 8 groups (n=5). Animals from IsoM and SevoM groups (control) were not anesthetized. Rats from IsoI, Iso2, Iso3 groups were anesthetized with isoflurane, and the ones from Sevo1, Sevo2, Sevo3 groups with sevoflurane (3 times, with 2 days interval between administrations, and the exposure time was 2 hours long every time). After anesthesia, we harvested blood samples at different moments: immediately after the anesthesia (groups IsoM, SevoM, Iso1 and Sevo1), 6 hours post-anestesia (Iso2 and Sevo2) and 24 hours post-anesthesia (Iso3 and Sevo3) and determined the transaminases. Upon statistical analysis, the results indicated the fact that the two anesthetics taken into study did not significantly modify the ASAT values. Also, isoflurane din not significantly modify ALAT values. On the other hand, after sevofluran anesthesia, ALAT values registered a statistically significant change. Enzymatic values ranged between normal limits or were slightly increased over the superior limit, which signifies that at the anesthetic dose and duration from our study, none of the tested anesthetics induce hepatic distress.

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“…Based on our results, integrity of tissue was intact in all groups, although spermatogonial cells population decreased in experimental group 2. Soubhia et al evaluated the effect of sevoflurane on transaminase on liver histology ( 23 ). Also, Elena et al studied some organs like spleen, kidney and liver after repeated sevoflurane anesthesia ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure of neonatal mice to Sevoflurane may induce male germ cell apoptosis in testicular tissue after puberty

Sistani

Maleki

Salimi

et al. 2017

IJRM

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Background:common use of sevoflurane in congenital defects during repeated surgeries may have detrimental effects on spermatogenesis after puberty.Objective:This study investigated sevoflurane effects on spermatogenesis process in male mature mice after exposure in prepubertal time.Materials and Methods:24 neonatal NMRI male mice were randomly classified in three groups. Experimental 1 and 2 groups (exposure to 1 minimum alveolar concentration (MAC) and 2 MAC sevoflurane, respectively in 2 lit/min oxygen (O2) for 7 days (30 min, daily) and control. All groups were sacrificed after 2 months. Histological assessment, immunohistochemistry and apoptosis process was done. Bax and Bcl2 expression was evaluated in the testicular tissue by real time Poly Chain Reaction.Results:Our results showed that the integrity of testicular tissue was preserved in both experimental groups. Count of spermatogonial cells had significant decrease in group 2 compared to others. The rate of apoptosis in spermatogonial cells was 15±3% and 9±2% in the group 2 and 1, respectively. Also, Bax/Bcl2 ratio was 0.2615, 1.0070 and 9.3657 in control, experimental group 1 and 2, respectively. This result was significant (p≤0.002) between groups 2 with other groups.Conclusion:Continuous exposure of 2 MAC sevoflurane in 2 lit/min O2 simultaneous during prepubertal may create more testicular tissue damage in terms of cellular and molecular function compared to continuous exposure to lower level of sevoflurane by increase in ratio of Bax/Bcl2 and apoptosis in germ cells after puberty.

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Effects of the Inhalational Anesthetics Halothane and Sevoflurane on an Experimental Model of Hepatic Injury

Abstract: Compared to the halothane group, sevoflurane did not show injuries of the liver parenchyma on optical microscopy.

Cited by 13 publications

References 10 publications

Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat

Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat

Presence and Distribution of the Vascularisation of Aortic Media in Some Mammals

Exposure of neonatal mice to Sevoflurane may induce male germ cell apoptosis in testicular tissue after puberty

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