Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance

Abstract

BackgroundThe prevalence of obesity continues to increase worldwide. Because obesity is associated with a number health-related problems as well as a shortened life span, treating obesity is an important clinical concern. Although various treatments are currently available, many are not efficacious in the long term. Therefore, additional medical treatment options for morbidly obese individuals must be explored. In this study, we examined the effects of the intragastric balloon MedSil® on anthropometric measures and hormones associated with lipid and energy metabolism.MethodsTwenty-two obese patients underwent insertion of the intragastric balloon MedSil® following a clinical exam, body composition scan, and collection of blood samples. Six months following implantation of the balloon, additional anthropometric and serological measures were taken.ResultsSix months following insertion of the MedSil® balloon, we observed significant decreases in body weight, body mass index, and fat mass. Compared with baseline levels, ghrelin serum levels were increased significantly, while leptin, FGF21, and glycated hemoglobin levels significantly decreased, 6 months after balloon insertion.ConclusionsThe MedSil® intragastric balloon is a safe and effective treatment for morbid obesity, with positive effects on anthropometric measures and lipid metabolism.

Elipse™, a Procedureless Gastric Balloon for Weight Loss: a Proof-of-Concept Pilot Study

“…In particular, there were no aspiration events during swallowing, small bowel obstructions during balloon passage, or evidence of ulcers. The nausea, vomiting, and abdominal cramps reported here was similar to previous studies on liquid-filled gastric balloons even though no prophylactic anti-emetic medications were administered [3,11].…”

Impact of a 6-month treatment with intragastric balloon on body composition and psychopathological profile in obese individuals with metabolic syndrome

“…A few studies have analyzed the body composition after 6 months of IGB using bioelectrical impedance, showing a significant reduction in fat mass and fat-free mass [24, 46, 47]. Bužga et al used DXA to verify the body composition after treatment with IGB and demonstrated sharp decreases in fat and lean mass [48]. Our patients also presented similar changes in body composition verified by DXA.…”

Obesity and Diabetes

“…Subsequently, the levels of ghrelin decreased but were still above baseline. Leptin significantly decreased, and the levels of adiponectin did not differ significantly (Buzga et al 2014).…”