Effects of the maternal consumption of alcohol on alcohol selection in rats

Reyes, Edward; García, Kelly; Jones, Brian Christopher

doi:10.1016/0741-8329(85)90068-0

Cited by 19 publications

(16 citation statements)

References 7 publications

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“…Although no data are presented about the daily consumption pattern of these doses, it is well known that food and fluid ingestion takes place mainly during the dark phase. This was corroborated in the study by Reyes et al (1985) in which pregnant rats with access to a liquid diet containing ethanol displayed significantly higher blood ethanol levels (170 mg% at 0700 h) at the end of the dark period than after the light phase (30 mg% at 1700 h). With the liquid diet procedure, increased ethanol intake has been detected in the offspring of dams consuming ethanol doses as low as 10.5 or 7.6 g/kg/day (Hilakivi, 1986;Hilakivi et al, 1987).…”

Section: -16supporting

confidence: 73%

“…In all those studies in which no effect of prenatal ethanol exposure on consumption was reported, ethanol doses administered to the dam ranged from 1 g/kg administered i.g. from GD7 to the end of gestation (Abel and York, 1979) to 16.85 g/kg consumed in an ethanol-containing liquid diet (Reyes et al, 1985). Considering that these ethanol doses are similar to those employed in studies in which the effect was observed, it can be concluded that the failure to observe increased ethanol intake in the afore-mentioned studies was not related to differences in the amount of ethanol reaching the fetus.…”

Section: -16mentioning

confidence: 91%

“…In order to extract any information regarding the ethanol doses that produce this effect, the way in which they were consumed by the pregnant dam should also be considered. Several researchers used a liquid diet containing ethanol (Bond and DiGiusto, 1976;Holloway and Tapp, 1978;McGivern et al, 1984;Randall et al, 1983;Reyes et al, 1985), others included ethanol solutions (or even Chablis wine) as the only liquid source (Hilakivi, 1986;Hilakivi et al, 1987;Honey and Galef, 2003;Nash et al, 1984;Phillips and Stainbrook, 1976), and yet others allowed the dams to choose between water and an ethanol-containing beverage (beer or an alcohol solution, sweetened or not) (Buckalew, 1979;Grace et al, 1986;Lancaster and Spiegel, 1989;Nelson et al, 1983). In five studies dams were administered a known dose of ethanol intragastrically (i.g.)…”

Section: -16mentioning

confidence: 97%

“…), modeling binge-like drinking. In studies in which dams self-administer ethanol, consumptions as high as 33 g/kg/day were found in mice (Randall et al, 1983) and 16.85 in rats (Reyes et al, 1985). Although no data are presented about the daily consumption pattern of these doses, it is well known that food and fluid ingestion takes place mainly during the dark phase.…”

Section: -16mentioning

confidence: 97%

See 3 more Smart Citations

Increased ethanol intake after prenatal ethanol exposure: Studies with animals

Chotro

Arias

Laviola

2007

Neuroscience & Biobehavioral Reviews

108

102

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Section: -16supporting

confidence: 73%

Section: -16mentioning

confidence: 91%

Section: -16mentioning

confidence: 97%

Section: -16mentioning

confidence: 97%

See 2 more Smart Citations

Increased ethanol intake after prenatal ethanol exposure: Studies with animals

Chotro

Arias

Laviola

2007

Neuroscience & Biobehavioral Reviews

108

102

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“…However, neither Abel and York (1979) and Anton (1983) found that mouse fetuses whose dams were exposed to the drug between G8 and birth consumed more ethanol during P25-P32 (i.e., the age range of juvenile and early adolescent development) than did controls, but this effect was not seen between P33 and P46. Reyes, Garcia, and Jones (1985) found that prenatal exposure from G1 until birth yielded greater preference for ethanol (in males only) for only the first half of a 30-day test in late adolescent/young adult rats (P45-P60). More recent studies with more selective prenatal exposure to ethanol (maternal intragastric administration of 1 or 2 g/kg ethanol during late gestation (G17-G20) have uniformly reported enhanced ethanol intake early in development, prior to weaning and in adolescence (Chotro et al, 2007;Molina, Spear, Spear, Mennella, & Lewis, 2007;Spear & Molina, 2005).…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats.

Youngentob¹,

Molina²,

Spear³

et al. 2007

Behavioral Neuroscience

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Clinical and epidemiological studies provide strong data for a relationship between prenatal ethanol exposure and the risk for abuse in adolescent and young adult humans. However, drugacceptance results in response to fetal exposure have differed by study, age at evaluation, and experimental animal. In the present study, the authors tested whether voluntary ethanol intake was enhanced in both the infantile and adult rat (15 and 90 days of age, respectively), as a consequence of chronic fetal drug experience. Experimental rats were exposed in utero by administering ethanol to a pregnant dam in a liquid diet during gestational Days 6-20. Compared with those for isocaloric pair-fed and ad lib chow control animals, the results for experimental animals demonstrated that fetal exposure significantly increased infantile affinity for ethanol ingestion without affecting intake patterns of an alternative fluid (water). Heightened affinity for ethanol was absent in adulthood. Moreover, the results argue against malnutrition as a principal factor underlying the infantile phenomenon. These data add to a growing literature indicative of heightened early postnatal acceptance patterns resulting from maternal use or abuse of ethanol during pregnancy. Keywordsfetal ethanol exposure; postnatal ethanol affinity; ethanol abuse; ethanol drinking behavior; fetal learning It has been well established that prenatal exposure to ethanol can exert profound detrimental effects in the developing fetus. The effects can be widespread, severe, and generally permanent. Depending on timing of exposure, and its duration and dose, these include stereotypical craniofacial malformations, poor suckling reflexes, decreased birth weight NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript (Abel & Hannigan, 1995;Astley, Clarren, Little, Sampson, & Daling, 1992;Clareen & Smith, 1978;Jones, Smith, Ulleland, & Streissguth, 1973; Lemoine, Harousseau, Borteyru, & Meneut, 1968;Martin, Martin, Streissguth, & Lund, 1977;Osborn, Harris, & Weinberg, 1993;Oulette, Rosett, Rosman, & Weiner, 1977;Streissguth, Landesman-Dwyer, Martin, & Smith, 1980;Ulleland, Wennburg, Igo, & Smith, 1970;Van Dyke, MacKay, & Ziaylek, 1982), and other profound neurodevelopmental effects in the nervous system Miller, 1992b). Prenatal exposure to ethanol can cause behavioral changes, such as hyperactivity, and learning and memory deficits: Indeed, gestational exposure is a leading known cause of mental retardation (Abel & Hannigan, 1995;Abel & Sokol, 1992;Sampson et al., 1997;Stratton, Howe, & Battaglia, 1996).The above notwithstanding, there are subtler yet potentially just as detrimental long-term consequences. Recent clinical and epidemiological studies indicate that prenatal exposure to ethanol is strongly associated with the risk for ethanol abuse in adolescent and young adult humans (Alati et al., 2006;Baer, Bar, Bookstein, Sampson, & Streissguth, 1998;Streissguth, 1998;Yates, Cadoret, Troughton, Steward, & Giunta, 1998). In effect, gestational exposure...

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Ethanol consumption by rat dams during gestation, lactation and weaning increases ethanol consumption by their adolescent young

Honey

Galef

2003

Developmental Psychobiology

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In two experiments, we examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam throughout gestation, lactation, and weaning enhanced voluntary ethanol consumption by 26- to 33-day-old adolescents. We systematically examined effects on adolescent ethanol intake or requiring dams to drink ethanol during various periods in their pups' development. We found that exposure to an ethanol-consuming dam during weaning enhanced adolescent ethanol consumption and exposure to a dam drinking ethanol during either gestation or while nursing enhanced adolescents' ethanol consumption only if pups also had access to ethanol during the weaning period.

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Effects of the maternal consumption of alcohol on alcohol selection in rats

Cited by 19 publications

References 7 publications

Increased ethanol intake after prenatal ethanol exposure: Studies with animals

Increased ethanol intake after prenatal ethanol exposure: Studies with animals

The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats.

Ethanol consumption by rat dams during gestation, lactation and weaning increases ethanol consumption by their adolescent young

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