Effects of the Mixture of Eucommia ulmoides Oliver and Achyranthes japonica Nakai Extracts (KGC08EA) on Testosterone Synthesis in Late-Onset Hypogonadism (LOH) in vitro Models

Kim, Seokho; Kim, Sohyuk; Kim, Jong Han; Kwon, Han Ol; Lee, Jeong Seon; Jun, Woojin; Lee, Yoo‐Hyun

doi:10.3746/jkfn.2020.49.10.1054

Cited by 2 publications

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“…Our findings suggest that EUAJ (3:1) ameliorated andropause symptoms by increasing testosterone levels and enhancing physical function (Figure 8). Similar to a previous study [51], EUAJ (3:1) restored the age-related decline in testosterone in aged SD rats by modulating steroidogenesis gene expression in the testes. Bioavailable testosterone is a decisive factor in muscle strength and physical function.…”

Section: Discussionsupporting

confidence: 86%

The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica on Alleviation of Testosterone Deficiency in Aged Rat Models

et al. 2022

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With aging, men inevitably encounter irreversible changes, including progressive loss of testosterone and physical strength, and increased fat mass. To assess the alleviatory effects of EUAJ on andropause symptoms, including in vivo testosterone deficiency, we administered EUAJ for 6 weeks in 22-week-old Sprague-Dawley rats. Before EUAJ (3:1) (E. ulmoides:A. japonica = 3:1, KGC08EA) administration, testosterone decline in 22-week-old SD rats was confirmed compared to 7-week-old SD rats (NC group). After administration of EUAJ (3:1) at 20, 40, and 80 mg/kg for 6 weeks, testosterone, free testosterone, and mRNA expression levels (Cyp11a1 and Hsd3b1) were significantly increased at 40 mg/kg EUAJ (3:1), whereas mRNA expression levels of Cyp19a1 and Srd5a2 were significantly reduced at this concentration, compared to the control group. Swimming retention time was significantly increased at both 40 mg/kg and 80 mg/kg. In summary, EUAJ (3:1) enhanced testosterone production by increasing bioavailable testosterone, sex hormone-binding globulin (SHBG), and enzymes related to testosterone synthesis at 40 mg/kg. In addition, 80 mg/kg EUAJ (3:1) also increased physical and testicular functions.

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Section: Discussionsupporting

confidence: 86%

The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica on Alleviation of Testosterone Deficiency in Aged Rat Models

et al. 2022

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The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica (KGC08EA) on Body Weight in High-Fat Diet-Induced Obese Mice

Kwon,

So,

Shim

et al. 2023

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In this study, a combination of Eucommia ulmoides and Achyranthes japonica (KGC08EA) demonstrated anti-obesity effects related to energy and lipid metabolism in vivo. To confirm their effectiveness in animals, high-fat diet (HFD) induced C57BL/6J mice were orally administrated KGC08EA for 9 weeks. The experimental groups were as follows: NC (C57BL/6J on a normal diet), C (HFD), PC (Coleus forskohlii, 100 mg/kg b.w.), EA100 (KGC08EA, 100 mg/kg b.w.), EA200 (KGC08EA, 200 mg/kg b.w.), EA400 (KGC08EA, 400 mg/kg b.w.), and EA800 (KGC08EA, 800 mg/kg b.w.). KGC08EA significantly decreased body weight, total fat and serum leptin, alanine aminotransferase, triglycerides, total cholesterol, and low density lipoprotein but significantly increased serum adiponectin. KGC08EA enhanced levels of energy and lipid metabolism modulators, such as phosphorylated adenosine monophosphate activated protein kinase, glucagon-like peptied 1 receptor, peroxisome proliferator-activated receptor gamma, acetyl-CoA carboxylase, and hormone-sensitive lipase, in liver and epididymal fat. These results suggest that KGC08EA has potential use as a health food for obesity.

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Effects of the Mixture of Eucommia ulmoides Oliver and Achyranthes japonica Nakai Extracts (KGC08EA) on Testosterone Synthesis in Late-Onset Hypogonadism (LOH) in vitro Models

Cited by 2 publications

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The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica on Alleviation of Testosterone Deficiency in Aged Rat Models

The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica on Alleviation of Testosterone Deficiency in Aged Rat Models

The Effect of a Combination of Eucommia ulmoides and Achyranthes japonica (KGC08EA) on Body Weight in High-Fat Diet-Induced Obese Mice

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