Effects of the nature of counterions in solution on interactions of phenoxazones, xanthones, and carbazoles containing benzo-crown groups with DNA

Eb, Moroshkina; Bogdanov, A. V.; Kolonistova, M. O.; Sedova, O. B.; Urusova, T. A.

doi:10.1007/s10947-009-0147-3

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…There are several modes of binding of these compounds with DNA as monomers or as aggregates on the surface of the double helix [2,3]. The most biologically significant binding is a monomeric ligand binding with DNA.…”

Section: Introductionmentioning

confidence: 99%

“…In this case the chromophore intercalates into double helix, or it locates in the minor groove of the DNA double helix. Previously, it was shown on the interaction of DNA with derivatives of actinocine [4], xanthone [3], phenazine [5] that the localization of molecule of the ligand upon binding is determined by the ionic conditions [3] and its structural features [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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The interaction of DNA with piperazine derivatives of benzoimidazophthalazine

Osinnikova

Travkina

2016

J. Phys.: Conf. Ser.

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Abstract. The interaction of DNA molecule with new synthetic compounds, piperazine derivatives of benzo [4,5]imidazo[1,2-a]phthalazine, was investigated by the spectral, hydrodynamic and optical methods. The thermodynamic parameters of the interaction and the stoichiometry of the complexes were determined by spectrophotometric titration. A mode of binding and structure of the complexes were determined by analyzing the changes in the intrinsic viscosity and the optical anisotropy of the macromolecule upon complexation. It is shown that an increase in the intrinsic viscosity and the optical anisotropy with a small content of the ligand in the complex is caused by the increase in the thermodynamic rigidity of macromolecules upon the formation of the complex. Increase of the contour length of the macromolecule in the complex does not occur, that indicates nonintercalative mode of binding the piperazine derivatives of benzoimidazophthalazine with DNA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The interaction of DNA with piperazine derivatives of benzoimidazophthalazine

Osinnikova

Travkina

2016

J. Phys.: Conf. Ser.

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“…Studies of the interaction of these compounds with DNA by spectral, optical, and hydrodynamic methods [16] have shown that owing to the presence of two crown groups the molecule can take different conformations depending on the spacer length linking crown groups with chromophor or on the number of alkali metal ions. The molecule conformation determines its binding to the double DNA helix.…”

Section: Introductionmentioning

confidence: 99%

Formation of the aggregates of actinocin derivatives containing 4′-benzo-15-crown-5 radicals in amide groups and their interaction with a DNA molecule

Sedova

Urusova

2011

J Struct Chem

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Methods of spectrophotometry, spectropolarimetry, and viscometry are used to study the self-organization in the solution of crown-containing actinocin derivative (I) exhibiting antitumor activity and the interaction of the formed aggregates with a DNA molecule. The presence of the 4′-benzo-15-crown-5 radical in the structure of the studied compound determines the observed differences in its complexation with Na + and K + ions. The process of aggregation in the presence of K + ions is accompanied by a shift of the long-wave band in the absorption spectrum to short-wave (the formation of H type aggregates) or long-wave (the formation of J type aggregates) regions depending on the K + ion concentration in the solution. In the presence of Na + ions, regardless of their concentration in the solution, J type aggregates form. A scheme of complex formation and their mutual transformations with changes in the ionic composition of the medium is proposed. A study of the interaction of this compound with DNA shows that in the presence of K + ions it binds to the DNA molecule in the form of monomers and/or dimers without producing large supramolecular aggregates. The H and J structures formed in K + -containing solutions of compound I are broken in the interaction with DNA. If a solution of compound I is added to a DNA solution containing Na + ions, the J type aggregates are formed directly on the surface of the DNA molecule. At the same type, the J structures originally formed in the Na + -containing solution of compound I practically do not interact with DNA. A study of this system shows that the introduction of the crown group in the compound molecule with a heterocyclic chromophore provides the opportunity to affect its affinity and binding to the DNA molecule by means of the ionic composition of the medium.

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Effects of the nature of counterions in solution on interactions of phenoxazones, xanthones, and carbazoles containing benzo-crown groups with DNA

Cited by 2 publications

References 15 publications

The interaction of DNA with piperazine derivatives of benzoimidazophthalazine

The interaction of DNA with piperazine derivatives of benzoimidazophthalazine

Formation of the aggregates of actinocin derivatives containing 4′-benzo-15-crown-5 radicals in amide groups and their interaction with a DNA molecule

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