Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio)

Stancová, Vlasta; Ziková, Andrea; Svobodová, Zdeňka; Kloas, Werner

doi:10.1016/j.etap.2015.07.009

Cited by 62 publications

(15 citation statements)

References 20 publications

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“…Diclofenac also increased hepatic oxidative stress [18] in Hoplias malabaricus. Other studies have demonstrated similar effects of diclofenac on oxidative stress responses in Cyprinus carpio [3,19,20] and Danio rerio [21]. Hematological profiles were also altered in C. carpio [22] and Clarias gariepinus [23] as a result of diclofenac exposure.…”

Section: Introductionsupporting

confidence: 53%

“…Previous studies have shown that diclofenac exposure reduced nitric oxide production in primary cultures of leukocytes [16]. Other studies have demonstrated similar effects of diclofenac on oxidative stress responses in Cyprinus carpio [3,19,20] and Danio rerio [21]. Diclofenac also increased hepatic oxidative stress [18] in Hoplias malabaricus.…”

Section: Introductionmentioning

confidence: 78%

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Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac

Ribas

Sherry

Zampronio

et al. 2017

Enviro Toxic and Chemistry

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Nonsteroidal anti-inflammatory drugs are among the most widely detected pharmaceuticals in surface water worldwide. The nonsteroidal anti-inflammatory drug diclofenac is used to treat many types of pain and inflammation. Diclofenac's potential to cause adverse effects in exposed wildlife is a growing concern. To evaluate the effects of waterborne diclofenac on the immune response in Rhamdia quelen (South American catfish), fish were exposed to 3 concentrations of diclofenac (0.2, 2.0, and 20.0 μg/L) for 14 d. Some of the exposed fish were also given an intraperitoneal injection on day 14 of 1 mg/kg of carrageenan to evaluate cell migration to the peritoneum. Total blood leukocyte count and carrageenan-induced leukocyte migration to the peritoneal cavity, particularly of polymorphonuclear cells, were significantly affected for all diclofenac exposure groups. Nitric oxide production was significantly reduced in the diclofenac-treated fish. Plasma and kidney proteins were analyzed by means of liquid chromatography-tandem mass spectrometry in a shotgun proteomic approach. In both plasma and kidney of diclofenac-exposed R. quelen, the expression of 20 proteins related to the inflammatory process, nitric oxide production, leukocyte migration, and the complement cascade was significantly altered. In addition, class I major histocompatibility complex was significantly decreased in plasma of diclofenac-treated fish. Thus, waterborne exposure to diclofenac could lead to suppression of the innate immune system in R. quelen. Environ Toxicol Chem 2017;36:2092-2107. © 2017 SETAC.

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Section: Introductionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 78%

Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac

Ribas

Sherry

Zampronio

et al. 2017

Enviro Toxic and Chemistry

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“…NSAID‐induced LPO and oxidative stress might also cause ulcers in the GI mucosa . Some reports have indicated that oral administration of NSAIDs causes GI oxidative injury through increased lactate dehydrogenase leakage, mucosal LPO (malondialdehyde, MDA), DNA damage, and decreased gastric mucus secretion in vivo . Thus, upregulation of antioxidant enzymes, such as GPx, GR, SOD, and HO‐1, might be a major mechanism of action against oxidative stress associated GI ulcers.…”

Section: Relationship Between Nsaid‐induced Oxidative Injury Of the Gmentioning

confidence: 99%

Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa

Cheng

Yen

2017

Molecular Nutrition Food Res

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The gastrointestinal (GI) mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Nonsteroidal anti-inflammatory drugs, including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to GI damage such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and have been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo. Therefore, the reduction of oxidative stress may be an effective curative strategy for preventing and treating nonsteroidal anti-inflammatory drug induced ulcers of the GI mucosa. Phytochemicals, such as dietary phenolic compounds, phenolic acids, flavan-3-ols, flavonols, flavonoids, gingerols, carotenes, and organosulfur, are common antioxidants in fruits, vegetables, and beverages. A large amount of evidence has demonstrated that natural phytochemicals possess bioactivity and potential health benefits, such as antioxidant, anti-inflammatory, and antibacterial benefits, and they can prevent digestive disease processes. In this review, we summarize the literature on phytochemicals with biological effects, such as angiogenic, antioxidant, antiapoptotic, anti-inflammatory, and antiulceration effects, and their related mechanisms are also discussed.

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“…The analysis on the usefulness of various methods of removing naproxen revealed that high efficiency was obtained in the cases of using oxidation, membrane and adsorption methodologies (Klavarioti et al, 2009;Monteiro and Boxall, 2010;Tambosi et al, 2010). However, it should be stressed that in many cases, the naproxen oxidation products are more toxic than the parent compound (Stancova et al, 2015). Taking into account the high efficiency of adsorption, the lack of by-products and the ease of the process, this methodology should be considered for the removal of naproxen.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Naproxen Sodium from Aqueous Solutions on Commercial Activated Carbons

Lach¹,

Szymonik²

2019

J. Ecol. Eng.

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The pollution of surface and drinking water with pharmaceuticals is one of the growing problems. One of the groups used in large quantities involves nonsteroidal anti-inflammatory drugs which can be bought without a prescription. This group includes naproxen, which was identified in wastewater, surface water and even drinking water all over the world. The aim of the study was to assess the opportunities for the removal of naproxen sodium from water using carbon sorbents. The measurements were carried out for three commercial microporous (WG-12 and F-300) and micro-mesoporous (ROW 08 Supra) activated carbons. The kinetics and statics of adsorption were studied. The adsorption from solutions with pH from 6 to 10 and temperature from 20 o C to 40 o C was analysed. It was found that the higher the pH, the lower the adsorption and the higher the temperature, the greater the adsorption of naproxen sodium. The highest adsorption of naproxen sodium was obtained for the F-300 activated carbon, whereas the lowest-for the ROW 08 Supra activated carbon. It was found that the adsorption results depend on many factors, the most important of which include hydrogen bonds between carboxyl groups of naproxen sodium and phenolic groups on the surface of activated carbons and electrostatic repulsion between the anions of naproxen sodium and negatively charged the surface of the activated carbon. The results of adsorption kinetics were described with the following models: pseudo-first order and pseudo-second order, intraparticle diffusion, and Elovich. The highest values of correlation coefficient R 2 were obtained for the pseudo-second order and Elovich model. The results of adsorption statics were described using the Freundlich, Langmuir, and Temkin models. A good match between isotherms and the obtained results was obtained for the Freundlich and Temkin equations. It was found based on the adsorption intensity 1/n and distribution coefficient R L that this process was beneficial for all the considered activated carbons and the investigated adsorption conditions.

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Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio)

Cited by 62 publications

References 20 publications

Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac

Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac

Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa

Adsorption of Naproxen Sodium from Aqueous Solutions on Commercial Activated Carbons

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