Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa

Cheng, Yu‐Ting; Lu, Chi‐Cheng; Yen, Gow‐Chin

doi:10.1002/mnfr.201600659

Cited by 34 publications

(31 citation statements)

References 118 publications

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“…Traditionally, curcumin is very often used to relieve many symptoms of various gastrointestinal diseases, such as diarrhea, indigestion, efflux, and even gastric and duodenal ulcers [ 6 ]. It is also able to diminish adverse effects after medication, i.e., through mucosal protection from the gastric damage induced by non-steroidal anti-inflammatory drugs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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Curcumin, a principal bioactive substance of turmeric (Curcuma longa L.), is reported as a strong antioxidant, anti-inflammatory, antibacterial, antifungal, and antiviral agent. However, its antimicrobial properties require further detailed investigations into clinical and multidrug-resistant (MDR) isolates. In this work, we tested curcumin’s efficacy against over 100 strains of pathogens belonging to 19 species. This activity was determined by the broth microdilution method and by calculating the minimum inhibitory concentration (MIC). Our findings confirmed a much greater sensitivity of Gram-positive than Gram-negative bacteria. This study exhibited a significantly larger variation in the curcumin activity than previous works and suggested that numerous clinical strains of widespread pathogens have a poor sensitivity to curcumin. Similarly, the MICs of the MDR types of Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Proteus mirabilis were high (≥2000 µg/mL). However, curcumin was effective against some species and strains: Streptococcus pyogenes (median MIC = 31.25 µg/mL), methicillin-sensitive S. aureus (250 µg/mL), Acinetobacter lwoffii (250 µg/mL), and individual strains of Enterococcus faecalis and Pseudomonas aeruginosa (62.5 µg/mL). The sensitivity of species was not associated with its affiliation to the genus, and it could differ a lot (e.g., S. pyogenes, S. agalactiae and A. lwoffii, A. baumannii). Hence, curcumin can be considered as a promising antibacterial agent, but with a very selective activity.

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Section: Introductionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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“…However it provokes aggressive ulcerogenic potential in both animals and humans [2]. Many previous studies tried to decrease damaging indomethacin effect on gastrointestinal mucosa [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Vanillin on Indomethacin-Induced Gastric Ulcer in Rats: Protective Pathways and Anti-Secretory Mechanism

Ma¹,

Salahuddin²

2017

Clin Exp Pharmacol

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Indomethacin provokes aggressive ulcerogenic adverse effects. Natural products with fewer side effects are therefore highly requested to attenuate its gastric ulcer effect. Vanillin is a natural compound widely used as flavoring agent which has antioxidant activity. Therefore, the aim of this study was to investigate its gastroprotective effect against indomethacin induced gastric injury. Rats were divided into four groups; first group served as control, group 2: Treated with indomethacin (25 mg/kg, po.), group 3: Pre-treated with ranitidine (reference drug) (50 mg/kg, po., 5 days) before indomethacin and group 4: Pretreated with vanillin (100 mg/kg, po., 5 days). Pre-treatment with vanillin reduced ulcer index, gastric juice volume, free, total acidity and histopathological changes induced by indomethacin. Although it reduced gastric oxidative stress, it elevated enzymatic antioxidant activity and gastric nitric oxide content. Moreover, it reduced gastric NFκB protein expression and activity as well as inhibition in levels of proinflammatory cytokines, Myeloperoxidase (MPO) and caspase 3 activities. It down regulated gene expression of TNF-α, Cytokine-Induced Neutrophil Chemo Attractant (CINC-2α) and caspase-9 while lacking effect on mucosal prostaglandin E2 (PGE2) level. Collectively, vanillin displayed gastroprotective effects in indomethacin induced gastric ulcer by anti-secretory action and cytoprotective effect via antioxidant and anti-inflammatory activities.

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“…Therefore, the reduction of oxidative stress may be an effective curative strategy for preventing and treating NSAIDs-induced gastric mucosal complications, such as micro bleedings and hemorrhagic lesions. The alternative therapy by phytochemicals such as supplementation by the dietary phenolic compounds including curcumin, could exert antioxidant, anti-inflammatory, and antibacterial benefits, thus preventing digestive diseases of upper GI tract including the ulcerogenic activity of NSAIDs [30].…”

Section: Curcumin-induced Gastric Protection Against Nsaid-inducedmentioning

confidence: 99%

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

Kwiecień

Magierowski

Majka

et al. 2019

IJMS

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Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. This review was designed to analyze the existing data from in vitro and in vivo animal and human studies in order to highlight the mechanisms of therapeutic efficacy of curcumin in the protection and ulcer healing of the upper gastrointestinal tract, with a major focus on addressing the protection of the esophagus and stomach by this emerging compound.

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Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa

Cited by 34 publications

References 118 publications

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Gastroprotective Effect of Vanillin on Indomethacin-Induced Gastric Ulcer in Rats: Protective Pathways and Anti-Secretory Mechanism

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

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