Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

Kwiecień, Sławomir; Magierowski, Marcin; Majka, Jolanta; Ptak‐Belowska, Agata; Wójcik, Dagmara; Śliwowski, Zbigniew; Magierowska, Katarzyna; Brzozowski, T

doi:10.3390/ijms20061477

Cited by 63 publications

(37 citation statements)

References 60 publications

(124 reference statements)

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“…Nowadays, turmeric and curcumin (the code of E100) are widely utilized as food additives with coloring, flavoring, and preservative properties (e.g., in mustard, margarine, butter, cheese, pasta, and beverages) [ 1 , 4 ]. Traditionally, curcumin is very often used to relieve many symptoms of various gastrointestinal diseases, such as diarrhea, indigestion, efflux, and even gastric and duodenal ulcers [ 6 ]. It is also able to diminish adverse effects after medication, i.e., through mucosal protection from the gastric damage induced by non-steroidal anti-inflammatory drugs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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Curcumin, a principal bioactive substance of turmeric (Curcuma longa L.), is reported as a strong antioxidant, anti-inflammatory, antibacterial, antifungal, and antiviral agent. However, its antimicrobial properties require further detailed investigations into clinical and multidrug-resistant (MDR) isolates. In this work, we tested curcumin’s efficacy against over 100 strains of pathogens belonging to 19 species. This activity was determined by the broth microdilution method and by calculating the minimum inhibitory concentration (MIC). Our findings confirmed a much greater sensitivity of Gram-positive than Gram-negative bacteria. This study exhibited a significantly larger variation in the curcumin activity than previous works and suggested that numerous clinical strains of widespread pathogens have a poor sensitivity to curcumin. Similarly, the MICs of the MDR types of Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Proteus mirabilis were high (≥2000 µg/mL). However, curcumin was effective against some species and strains: Streptococcus pyogenes (median MIC = 31.25 µg/mL), methicillin-sensitive S. aureus (250 µg/mL), Acinetobacter lwoffii (250 µg/mL), and individual strains of Enterococcus faecalis and Pseudomonas aeruginosa (62.5 µg/mL). The sensitivity of species was not associated with its affiliation to the genus, and it could differ a lot (e.g., S. pyogenes, S. agalactiae and A. lwoffii, A. baumannii). Hence, curcumin can be considered as a promising antibacterial agent, but with a very selective activity.

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Section: Introductionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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“…Polyphenolic substances such as curcumin have been found to exhibit antioxidant, anti-inflammatory, and antibacterial effects [ 15 , 16 ]. Also, curcumin treatment has also been shown to be effective in improving immune kidney disease, diabetes, and cardiovascular disease, and has been shown to act as a protective agent in gastroesophageal disease by protecting tissue damage, especially by improving inflammation and apoptosis [ 17 ]. Inflammation, which is the compensatory response about tissue injury, is induced in the increase of leukocytes and inflammatory factors such as cytokines and chemokines [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Lee

Shin

Kim

et al. 2021

BioMed Research International

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Gastroesophageal reflux disease (GERD) is induced by the reflux of stomach contents or gastric acid, pepsin into the esophagus for prolonged periods of time due to defection of the lower esophageal sphincter. Reflux esophagitis is a disease found in less than 50% of GERD patients. This study is aimed at evaluating the protective effect of Curcumae longae Rhizoma 30% EtOH extract (CLR) in acute reflux esophagitis (ARE) rats. CLR measured antioxidant activity through in vitro experiments. Based on the results, we performed experiments in vivo. Before 90 min ARE induction, CLR was administered orally by concentration. ARE was derived by linking the metastatic junction between pylorus and forestomach and corpus in Sprague-Dawley rats. And rats were sacrificed 5 h after surgery. We analyzed the expression of antioxidant and inflammatory-related markers by western blot and observed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), reactive oxygen species (ROS), peroxynitrite (ONOO-), and thiobarbituric acid reactive substance (TBARS). The administration of CLR reduced esophagus tissue damage in rats with acute reflux esophagitis and decreased the elevated ALT, AST, ROS, ONOO-, and TBARS. In addition, CLR effectively increased antioxidant-related factors and reduced inflammatory protein. Overall, these results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE. Overall, CLR treatment informed that markedly ameliorated inactivation of NF-κB led to the inhibition of the expressions of proinflammatory proteins. These results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE.

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“…demonstrated that curcumin prevented liver damage possibly by modulating NF‐κB translocation (Afrin et al, 2017). Therapeutic potential of curcumin in GI diseases was elaborately summarized (Burge, Gunasekaran, Eckert, & Chaaban, 2019; Kwiecien et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

et al. 2020

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Long‐term use of tolfenamic acid inevitably causes side effects, including gastric ulcer and hepatotoxicity. Curcumin is generally recognized to be anti‐inflammatory, hepatoprotective, and gastroprotective. Herein, we investigated the combinational effects of tolfenamic acid and curcumin and possible mechanism in a TPA‐induced inflammation mouse model. Combinational use of tolfenamic acid (100 mg/kg) and curcumin (100 mg/kg) by oral administration reduced dermal inflammation represented by ear edema and lymphocytic infiltration. Moreover, curcumin dispersed in polyvinyl pyrrolidone showed stronger synergistic effect. The beneficial effect of the coadministration was also reproduced in PKC/Akt/IKK/NF‐κB signaling pathways. Notably, hepatoprotective and gastroprotective effect was exhibited by the reverse of body weight loss and NF‐κB downregulation in the liver, and by increased Spleen Index of mice. These results suggested combination administration of tolfenamic acid with curcumin enhances anti‐inflammatory efficacy and reduces hepatic/gastric toxicity, which indicates dietary uptake of curcumin may facilitate the function of tolfenamic acid. Practical applications Curcumin, a representative polyphenolic compound, is one of the main constituents of dietary spice turmeric which has been widely consumed throughout the world, especially in Asia. The beneficial aspect of combination use of curcumin in enhancing anti‐inflammatory effect and reducing hepatic/gastric toxicity of NSAID drug tolfenamic acid in mice has been explored. It might be anticipated as a potential naturally derived bioactive constituent in functional food and pharmaceutical applications.

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Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

Cited by 63 publications

References 60 publications

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

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