To assess the performance of kids under different disbudding pre-medication regimes, 24 kids of 14-15 days were randomly designated as D 0 (control, no medication), D L (local anaesthetics, 2% lignocaine, 1 ml/bud as cornual nerve block), D M (non-steroidal analgesic, meloxicam with 0.25 mg/kg body weight by I/M route) and D L + M (both lignocaine and meloxicam) with six in each group. First fortnight after hot-iron disbudding, ADG was higher (P < 0.05) in D M than control. FCR was significantly (P < 0.05) better in D M and D L over control. PER was non-significantly higher in D M , D L and D L + M over control by 24.86%, 22.70% and 17.84%, respectively. Hb and PCV was higher (P < 0.01) in D M followed by D L , D L + M and D 0 . Neutrophil, lymphocyte, eosinophil and basophil counts were higher in D L than other treatment groups. Neutrophil-to-lymphocyte ratio was higher (P < 0.01) in D M than other treatment groups. Effect of disbudding pre-medication on serum biochemistry like glucose, total protein, albumin and globulin was significantly affected (P < 0.01) by pre-disbudding treatments among different groups. During entire study period, serum cortisol was lower (P < 0.01) in D M , T 3 was higher in D 0 and T 4 was higher in D L than other groups; however, TSH was lower (P < 0.01) in D M than other three groups. It was concluded that non-steroidal analgesic-medicated kids had better performance and disbudding distress persists up to 15 days irrespective of different pre-disbudding medication regime.