Effects of the pharmaceuticals gemfibrozil and diclofenac on biomarker expression in the zebra mussel (Dreissena polymorpha) and their comparison with standardised toxicity tests

Quinn, Brian; Schmidt, Wiebke; O’Rourke, Kathleen; Hernan, Robert

doi:10.1016/j.chemosphere.2011.03.033

Cited by 125 publications

(57 citation statements)

References 42 publications

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“…In the current study, investigated mussels showed insignificant temporal and spatial variability in the condition index and total protein content, suggesting their closely similar physiological states. The range of biomarker levels (MT, EROD, LPO, DNA_sb, Vtg) detected in dreissenids inhabiting Lake Balaton were comparable with previously reported data for zebra mussels populating various aquatic habitats, either pristine-or affected by certain anthropogenic impact, as the St Lawrence River in Canada (de Lafontaine et al, 2000), Lago Maggiore in Italy (Binelli et al, 2005) or Lough Ree in Ireland (Quinn et al, 2011). Moreover, the spatial and temporal alternation of these biomarkers fell within ranges and followed similar pattern with that previously reported for pure D. bugensis populations inhabiting Lake Balaton (Ács et al, 2016).…”

Section: Discussionsupporting

confidence: 90%

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Farkas

Ács

Vehovszky

et al. 2017

Science of The Total Environment

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Stress biomarkers, which can outline impacts of contaminants in aquatic biota at the biochemical level, are increasingly used as early warning tools in environmental monitoring. Reliable biomarker based assessment schemes, however, request appropriate knowledge of baseline levels of selected endpoints, and the potential influence of a range of natural influencing factors (both abiotic and biotic) as well. In this study, we examined the interspecies variability of various biomarkers (metallothioneins (MT), ethoxyresorufin-Odeethylase activity (EROD), lipid peroxidation (LPO), DNA strand breaks (DNA_sb), vitellogenin-like proteins (Vtg)) in Dreissena polymorpha and Dreissena bugensis inhabiting either pristine-or moderately impacted sites of Lake Balaton (Hungary). Levels of all biomarkers considered revealed low interspecies variability in the two dreissenid species at all sampling sites, with consistently higher (but statistically insignificant) values in Dreissena polymorpha. Levels of all biomarkers varied within the two investigated seasons, with significant influence of the reproduction cycle particularly on the levels of metallothioneins and vitellogenin-like proteins. Each biomarker considered was elevated by October, with significantly higher values in the mussels inhabiting harbours. Insignificant spatial and temporal variability in the general health indicators (condition index, total protein content) of dreissenids was observed, which, in parallel with evident rise in biomarker levels, apparently suggest that the anthropogenic impacts in harbours affect mussel fitness yet at sub organismal level. Our data might serve useful basis for future environmental monitoring surveys, especially in habitats where the progressive replacement of Dreissena polymorpha by Dreissena bugensis is taking place, as the interspecies variability in susceptibility to chemical stress of the two species is well comparable.

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Section: Discussionsupporting

confidence: 90%

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Farkas

Ács

Vehovszky

et al. 2017

Science of The Total Environment

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“…Another biomarker, lipid peroxidation, was found to be affected at concentration of 1 μg/L in D. polymorpha exposed for 96 h [73]. The previous biomarker was sensitive for blue mussels Mytilus spp.…”

Section: Nonsteroidal Anti-inflammatory Drugs: the Example Of Diclofementioning

confidence: 95%

Bioassays Currently Available for Evaluating the Biological Potency of Pharmaceuticals in Treated Wastewater

Vasquez

Michael²,

Kümmerer

et al. 2015

The Handbook of Environmental Chemistry

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Water deprivation with regard to quantity and quality is one of the most important environmental problems of the century. The increasing demand of water resources puts pressure on the utilization of alternative sources such as treated wastewater. In the context of "reduce, reuse, and recycle," the inclusion of treated wastewater in the water cycle seems a promising practice for water management. The lack of general acceptance of stakeholders and public, however, still hinders the widespread application of wastewater reuse. A reason for this is, among others, the presence of contaminants of emerging concern in treated wastewater. This has led to an increased concern about direct and indirect effects to the environment and possible implications to human health. The development and application of bioassays able to identify and quantify the biological potency of treated wastewater is an ongoing research effort, especially when taking into consideration that a plethora of contaminants exist and interact in this complex matrix. This chapter summarizes available literature regarding the sensitivity of currently applied bioassays for assessing biological effects of treated wastewater and their correlation with chemical analysis. The focus is on pharmaceuticals since they represent one of the major groups of contaminants of emerging concern with many unanswered questions currently in place.

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“…Mihaich et al (2009) determined EC 50 =7.8-32 mg/L (Table 1) for bisphenol A measuring frond biomass and frond density, while the LOEC value is 12.5 mg/L according to our results. In terms of the population abundance [42] and the total frond area [41] EC 50 values were 47.6 µg/L and 7.5 mg/L respectively for Na-diclofenac (Table 1). In our research the LOEC value is 3.125 mg/L.…”

Section: Discussionmentioning

confidence: 99%

Assessing Toxicity of Organic Aquatic Micropollutants Based on the Total Chlorophyll Content of Lemna minor as a Sensitive Endpoint

Fekete-Kertész

Kunglné-Nagy

Gruiz

et al. 2015

Period. Polytech. Chem. Eng.

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Effects of the pharmaceuticals gemfibrozil and diclofenac on biomarker expression in the zebra mussel (Dreissena polymorpha) and their comparison with standardised toxicity tests

Cited by 125 publications

References 42 publications

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Bioassays Currently Available for Evaluating the Biological Potency of Pharmaceuticals in Treated Wastewater

Assessing Toxicity of Organic Aquatic Micropollutants Based on the Total Chlorophyll Content of Lemna minor as a Sensitive Endpoint

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